Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling. / Asgreen, Camilla; Knopp, Matthias Manne; Skytte, Jeppe; Loebmann, Korbinian.

In: Pharmaceutics, Vol. 12, No. 6, 483, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Asgreen, C, Knopp, MM, Skytte, J & Loebmann, K 2020, 'Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling', Pharmaceutics, vol. 12, no. 6, 483. https://doi.org/10.3390/pharmaceutics12060483

APA

Asgreen, C., Knopp, M. M., Skytte, J., & Loebmann, K. (2020). Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling. Pharmaceutics, 12(6), [483]. https://doi.org/10.3390/pharmaceutics12060483

Vancouver

Asgreen C, Knopp MM, Skytte J, Loebmann K. Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling. Pharmaceutics. 2020;12(6). 483. https://doi.org/10.3390/pharmaceutics12060483

Author

Asgreen, Camilla ; Knopp, Matthias Manne ; Skytte, Jeppe ; Loebmann, Korbinian. / Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling. In: Pharmaceutics. 2020 ; Vol. 12, No. 6.

Bibtex

@article{9256b217bdd74250af9815e33f431302,
title = "Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling",
abstract = "In this study, the putative correlation between the molecular mobility of a polymer and the ball milling drug amorphization kinetics (i.e., time to reach full drug amorphization,t(a)) was studied using different grades of dextran (Dex) and polyvinylpyrrolidone (PVP) and the two model drugs indomethacin (IND) and chloramphenicol (CAP). In general, IND had lowert(a)values than CAP, indicating that IND amorphized faster than CAP in the presence of the polymers. In addition, an increase in polymer molecular weight (M-w) also led to an increase int(a)for all systems investigated up to a critical M(w)for each polymer, which was in line with an increase of the glass transition temperature (T-g) up to the critical M(w)of each polymer. Hence, the increase int(a)seemed to correlate well with the T-g/M(w)of the polymers, which indicates that the polymers' molecular mobility had an influence on the drug amorphization kinetics during ball milling.",
keywords = "amorphous, solid dispersion, ball-milling, milling time, amorphization kinetics, TERM PHYSICAL STABILITY, SOLUBILITY, PVP",
author = "Camilla Asgreen and Knopp, {Matthias Manne} and Jeppe Skytte and Korbinian Loebmann",
year = "2020",
doi = "10.3390/pharmaceutics12060483",
language = "English",
volume = "12",
journal = "Pharmaceutics",
issn = "1999-4923",
publisher = "MDPI AG",
number = "6",

}

RIS

TY - JOUR

T1 - Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling

AU - Asgreen, Camilla

AU - Knopp, Matthias Manne

AU - Skytte, Jeppe

AU - Loebmann, Korbinian

PY - 2020

Y1 - 2020

N2 - In this study, the putative correlation between the molecular mobility of a polymer and the ball milling drug amorphization kinetics (i.e., time to reach full drug amorphization,t(a)) was studied using different grades of dextran (Dex) and polyvinylpyrrolidone (PVP) and the two model drugs indomethacin (IND) and chloramphenicol (CAP). In general, IND had lowert(a)values than CAP, indicating that IND amorphized faster than CAP in the presence of the polymers. In addition, an increase in polymer molecular weight (M-w) also led to an increase int(a)for all systems investigated up to a critical M(w)for each polymer, which was in line with an increase of the glass transition temperature (T-g) up to the critical M(w)of each polymer. Hence, the increase int(a)seemed to correlate well with the T-g/M(w)of the polymers, which indicates that the polymers' molecular mobility had an influence on the drug amorphization kinetics during ball milling.

AB - In this study, the putative correlation between the molecular mobility of a polymer and the ball milling drug amorphization kinetics (i.e., time to reach full drug amorphization,t(a)) was studied using different grades of dextran (Dex) and polyvinylpyrrolidone (PVP) and the two model drugs indomethacin (IND) and chloramphenicol (CAP). In general, IND had lowert(a)values than CAP, indicating that IND amorphized faster than CAP in the presence of the polymers. In addition, an increase in polymer molecular weight (M-w) also led to an increase int(a)for all systems investigated up to a critical M(w)for each polymer, which was in line with an increase of the glass transition temperature (T-g) up to the critical M(w)of each polymer. Hence, the increase int(a)seemed to correlate well with the T-g/M(w)of the polymers, which indicates that the polymers' molecular mobility had an influence on the drug amorphization kinetics during ball milling.

KW - amorphous

KW - solid dispersion

KW - ball-milling

KW - milling time

KW - amorphization kinetics

KW - TERM PHYSICAL STABILITY

KW - SOLUBILITY

KW - PVP

U2 - 10.3390/pharmaceutics12060483

DO - 10.3390/pharmaceutics12060483

M3 - Journal article

C2 - 32471023

VL - 12

JO - Pharmaceutics

JF - Pharmaceutics

SN - 1999-4923

IS - 6

M1 - 483

ER -

ID: 248503011