Impact of Molecular Surface Diffusion on the Physical Stability of Co-Amorphous Systems

Research output: Contribution to journalJournal articlepeer-review

Standard

Impact of Molecular Surface Diffusion on the Physical Stability of Co-Amorphous Systems. / Liu, Jingwen; Hwu, Ente; Bannow, Jacob; Grohganz, Holger; Rades, Thomas.

In: Molecular Pharmaceutics, Vol. 19, No. 4, 2022, p. 1183-1190.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Liu, J, Hwu, E, Bannow, J, Grohganz, H & Rades, T 2022, 'Impact of Molecular Surface Diffusion on the Physical Stability of Co-Amorphous Systems', Molecular Pharmaceutics, vol. 19, no. 4, pp. 1183-1190. https://doi.org/10.1021/acs.molpharmaceut.1c00973

APA

Liu, J., Hwu, E., Bannow, J., Grohganz, H., & Rades, T. (2022). Impact of Molecular Surface Diffusion on the Physical Stability of Co-Amorphous Systems. Molecular Pharmaceutics, 19(4), 1183-1190. https://doi.org/10.1021/acs.molpharmaceut.1c00973

Vancouver

Liu J, Hwu E, Bannow J, Grohganz H, Rades T. Impact of Molecular Surface Diffusion on the Physical Stability of Co-Amorphous Systems. Molecular Pharmaceutics. 2022;19(4):1183-1190. https://doi.org/10.1021/acs.molpharmaceut.1c00973

Author

Liu, Jingwen ; Hwu, Ente ; Bannow, Jacob ; Grohganz, Holger ; Rades, Thomas. / Impact of Molecular Surface Diffusion on the Physical Stability of Co-Amorphous Systems. In: Molecular Pharmaceutics. 2022 ; Vol. 19, No. 4. pp. 1183-1190.

Bibtex

@article{231b7640f1ac4f52b0a7d5294358976d,
title = "Impact of Molecular Surface Diffusion on the Physical Stability of Co-Amorphous Systems",
abstract = "In this study, surface diffusion of l-aspartic acid-carvedilol (ASP-CAR) co-amorphous systems at different ASP concentrations is measured and correlated with their physical stability. ASP-CAR films at ASP concentrations of 1-5% (w/w) were prepared by a newly developed method based on a vacuum compression molding process. Surface diffusion measurements were conducted on these systems based on the surface grating decay method using atomic force microscopy (AFM). The results demonstrate that a small amount of ASP (i.e., ≤ 5% w/w) in the co-amorphous systems could significantly slow down the grating decay process compared with that of pure amorphous CAR, indicating a reduced surface diffusion of CAR molecules. The decay time gradually increased in co-amorphous systems with increasing ASP concentration from 1 to 5% (w/w), with the longest observed decay time of around 800 h for the 5%ASP-CAR system, which was more than 200 times longer compared to the decay time of pure amorphous CAR (approximately 3 h). A good correlation between the decay constants of the pure amorphous CAR and co-amorphous films at ASP concentrations of 1-5% (w/w) and the physical stability of corresponding amorphous powder samples was found. Overall, this study provides a new method to prepare co-amorphous films for surface property measurements and reveals the impact of surface diffusion on the physical stability of co-amorphous systems. ",
keywords = "atomic force microscopy, co-amorphous, physical stability, surface diffusion, surface mobility",
author = "Jingwen Liu and Ente Hwu and Jacob Bannow and Holger Grohganz and Thomas Rades",
note = "Funding Information: J.L. acknowledges the China Scholarship Council (201806350247) for financial support. ",
year = "2022",
doi = "10.1021/acs.molpharmaceut.1c00973",
language = "English",
volume = "19",
pages = "1183--1190",
journal = "Molecular Pharmaceutics",
issn = "1543-8384",
publisher = "American Chemical Society",
number = "4",

}

RIS

TY - JOUR

T1 - Impact of Molecular Surface Diffusion on the Physical Stability of Co-Amorphous Systems

AU - Liu, Jingwen

AU - Hwu, Ente

AU - Bannow, Jacob

AU - Grohganz, Holger

AU - Rades, Thomas

N1 - Funding Information: J.L. acknowledges the China Scholarship Council (201806350247) for financial support.

PY - 2022

Y1 - 2022

N2 - In this study, surface diffusion of l-aspartic acid-carvedilol (ASP-CAR) co-amorphous systems at different ASP concentrations is measured and correlated with their physical stability. ASP-CAR films at ASP concentrations of 1-5% (w/w) were prepared by a newly developed method based on a vacuum compression molding process. Surface diffusion measurements were conducted on these systems based on the surface grating decay method using atomic force microscopy (AFM). The results demonstrate that a small amount of ASP (i.e., ≤ 5% w/w) in the co-amorphous systems could significantly slow down the grating decay process compared with that of pure amorphous CAR, indicating a reduced surface diffusion of CAR molecules. The decay time gradually increased in co-amorphous systems with increasing ASP concentration from 1 to 5% (w/w), with the longest observed decay time of around 800 h for the 5%ASP-CAR system, which was more than 200 times longer compared to the decay time of pure amorphous CAR (approximately 3 h). A good correlation between the decay constants of the pure amorphous CAR and co-amorphous films at ASP concentrations of 1-5% (w/w) and the physical stability of corresponding amorphous powder samples was found. Overall, this study provides a new method to prepare co-amorphous films for surface property measurements and reveals the impact of surface diffusion on the physical stability of co-amorphous systems.

AB - In this study, surface diffusion of l-aspartic acid-carvedilol (ASP-CAR) co-amorphous systems at different ASP concentrations is measured and correlated with their physical stability. ASP-CAR films at ASP concentrations of 1-5% (w/w) were prepared by a newly developed method based on a vacuum compression molding process. Surface diffusion measurements were conducted on these systems based on the surface grating decay method using atomic force microscopy (AFM). The results demonstrate that a small amount of ASP (i.e., ≤ 5% w/w) in the co-amorphous systems could significantly slow down the grating decay process compared with that of pure amorphous CAR, indicating a reduced surface diffusion of CAR molecules. The decay time gradually increased in co-amorphous systems with increasing ASP concentration from 1 to 5% (w/w), with the longest observed decay time of around 800 h for the 5%ASP-CAR system, which was more than 200 times longer compared to the decay time of pure amorphous CAR (approximately 3 h). A good correlation between the decay constants of the pure amorphous CAR and co-amorphous films at ASP concentrations of 1-5% (w/w) and the physical stability of corresponding amorphous powder samples was found. Overall, this study provides a new method to prepare co-amorphous films for surface property measurements and reveals the impact of surface diffusion on the physical stability of co-amorphous systems.

KW - atomic force microscopy

KW - co-amorphous

KW - physical stability

KW - surface diffusion

KW - surface mobility

U2 - 10.1021/acs.molpharmaceut.1c00973

DO - 10.1021/acs.molpharmaceut.1c00973

M3 - Journal article

C2 - 35230110

AN - SCOPUS:85126148898

VL - 19

SP - 1183

EP - 1190

JO - Molecular Pharmaceutics

JF - Molecular Pharmaceutics

SN - 1543-8384

IS - 4

ER -

ID: 305394910