Immunostimulatory colloidal delivery systems for cancer vaccines
Research output: Contribution to journal › Journal article › Research › peer-review
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Immunostimulatory colloidal delivery systems for cancer vaccines. / Saupe, Anne; McBurney, Warren; Rades, Thomas; Hook, Sarah.
In: Expert Opinion on Drug Delivery, Vol. 3, No. 3, 2006, p. 345-54.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Immunostimulatory colloidal delivery systems for cancer vaccines
AU - Saupe, Anne
AU - McBurney, Warren
AU - Rades, Thomas
AU - Hook, Sarah
PY - 2006
Y1 - 2006
N2 - Cancer vaccine delivery is a multidisciplinary scientific field that is currently undergoing rapid development. An important component of cancer vaccines is the development of novel vaccine delivery strategies, such as colloidal immunostimulatory delivery systems. The importance of formulation strategies for cancer vaccines can be explained by the poor immunogenicity of tumour antigens. Colloidal vaccine delivery systems modify the kinetics, body distribution, uptake and release of the vaccine. This review explores recent research that is directed towards more targeted treatments of cancer through to colloidal vaccine delivery systems. Widely investigated carrier systems include polymeric micro- and nanoparticles, liposomes, archaeal lipid liposomes (archaeosomes), immune-stimulating complexes and virus-like particles. These systems are evaluated in terms of their formulation techniques, immunological mechanisms of action as well as the potential and limitations of such colloidal systems in the field of cancer vaccines.
AB - Cancer vaccine delivery is a multidisciplinary scientific field that is currently undergoing rapid development. An important component of cancer vaccines is the development of novel vaccine delivery strategies, such as colloidal immunostimulatory delivery systems. The importance of formulation strategies for cancer vaccines can be explained by the poor immunogenicity of tumour antigens. Colloidal vaccine delivery systems modify the kinetics, body distribution, uptake and release of the vaccine. This review explores recent research that is directed towards more targeted treatments of cancer through to colloidal vaccine delivery systems. Widely investigated carrier systems include polymeric micro- and nanoparticles, liposomes, archaeal lipid liposomes (archaeosomes), immune-stimulating complexes and virus-like particles. These systems are evaluated in terms of their formulation techniques, immunological mechanisms of action as well as the potential and limitations of such colloidal systems in the field of cancer vaccines.
U2 - 10.1517/17425247.3.3.345
DO - 10.1517/17425247.3.3.345
M3 - Journal article
C2 - 16640495
VL - 3
SP - 345
EP - 354
JO - Expert Opinion on Drug Delivery
JF - Expert Opinion on Drug Delivery
SN - 1742-5247
IS - 3
ER -
ID: 40357500