Hydrate formation during wet granulation studied by spectroscopic methods and multivariate analysis

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Standard

Hydrate formation during wet granulation studied by spectroscopic methods and multivariate analysis. / Jørgensen, Anna; Rantanen, Jukka; Karjalainen, Milja; Khriachtchev, Leonid; Räsänen, Eetu; Yliruusi, Jouko.

In: Pharmaceutical Research, Vol. 19, No. 9, 09.2002, p. 1285-91.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Jørgensen, A, Rantanen, J, Karjalainen, M, Khriachtchev, L, Räsänen, E & Yliruusi, J 2002, 'Hydrate formation during wet granulation studied by spectroscopic methods and multivariate analysis', Pharmaceutical Research, vol. 19, no. 9, pp. 1285-91.

APA

Jørgensen, A., Rantanen, J., Karjalainen, M., Khriachtchev, L., Räsänen, E., & Yliruusi, J. (2002). Hydrate formation during wet granulation studied by spectroscopic methods and multivariate analysis. Pharmaceutical Research, 19(9), 1285-91.

Vancouver

Jørgensen A, Rantanen J, Karjalainen M, Khriachtchev L, Räsänen E, Yliruusi J. Hydrate formation during wet granulation studied by spectroscopic methods and multivariate analysis. Pharmaceutical Research. 2002 Sep;19(9):1285-91.

Author

Jørgensen, Anna ; Rantanen, Jukka ; Karjalainen, Milja ; Khriachtchev, Leonid ; Räsänen, Eetu ; Yliruusi, Jouko. / Hydrate formation during wet granulation studied by spectroscopic methods and multivariate analysis. In: Pharmaceutical Research. 2002 ; Vol. 19, No. 9. pp. 1285-91.

Bibtex

@article{6ebf7d95874c48eb8505ac09788eb99e,
title = "Hydrate formation during wet granulation studied by spectroscopic methods and multivariate analysis",
abstract = "PURPOSE: The aim was to follow hydrate formation of two structurally related drugs, theophylline and caffeine, during wet granulation using fast and nondestructive spectroscopic methods.METHODS: Anhydrous theophylline and caffeine were granulated with purified water. Charge-coupled device (CCD) Raman spectroscopy was compared with near-infrared spectroscopy (NIR) in following hydrate formation of drugs during wet granulation (off-line). To perform an at-line process analysis, the effect of water addition was monitored by NIR spectroscopy and principal components analysis (PCA). The changes in the crystal arrangements were verified by using X-ray powder diffraction (XRPD).RESULTS: Hydrate formation of theophylline and caffeine could be followed by CCD Raman spectroscopy. The NIR and Raman spectroscopic results were consistent with each other. NIR revealed the state of water, and Raman spectroscopy gave information related to the drug molecule itself. The XRPD confirmed the spectroscopic results. PCA with three principal components explained 99.9 of the spectral variation in the second derivative NIR spectra.CONCLUSIONS: Both CCD Raman and NIR spectroscopic methods can be applied to monitoring of hydrate formation processes. However, NIR is more suitable for monitoring solid-water interactions.",
keywords = "Multivariate Analysis, Spectrum Analysis, Raman, Technology, Pharmaceutical, Wettability, Wetting Agents",
author = "Anna J{\o}rgensen and Jukka Rantanen and Milja Karjalainen and Leonid Khriachtchev and Eetu R{\"a}s{\"a}nen and Jouko Yliruusi",
year = "2002",
month = "9",
language = "English",
volume = "19",
pages = "1285--91",
journal = "Pharmaceutical Research",
issn = "0724-8741",
publisher = "Springer",
number = "9",

}

RIS

TY - JOUR

T1 - Hydrate formation during wet granulation studied by spectroscopic methods and multivariate analysis

AU - Jørgensen, Anna

AU - Rantanen, Jukka

AU - Karjalainen, Milja

AU - Khriachtchev, Leonid

AU - Räsänen, Eetu

AU - Yliruusi, Jouko

PY - 2002/9

Y1 - 2002/9

N2 - PURPOSE: The aim was to follow hydrate formation of two structurally related drugs, theophylline and caffeine, during wet granulation using fast and nondestructive spectroscopic methods.METHODS: Anhydrous theophylline and caffeine were granulated with purified water. Charge-coupled device (CCD) Raman spectroscopy was compared with near-infrared spectroscopy (NIR) in following hydrate formation of drugs during wet granulation (off-line). To perform an at-line process analysis, the effect of water addition was monitored by NIR spectroscopy and principal components analysis (PCA). The changes in the crystal arrangements were verified by using X-ray powder diffraction (XRPD).RESULTS: Hydrate formation of theophylline and caffeine could be followed by CCD Raman spectroscopy. The NIR and Raman spectroscopic results were consistent with each other. NIR revealed the state of water, and Raman spectroscopy gave information related to the drug molecule itself. The XRPD confirmed the spectroscopic results. PCA with three principal components explained 99.9 of the spectral variation in the second derivative NIR spectra.CONCLUSIONS: Both CCD Raman and NIR spectroscopic methods can be applied to monitoring of hydrate formation processes. However, NIR is more suitable for monitoring solid-water interactions.

AB - PURPOSE: The aim was to follow hydrate formation of two structurally related drugs, theophylline and caffeine, during wet granulation using fast and nondestructive spectroscopic methods.METHODS: Anhydrous theophylline and caffeine were granulated with purified water. Charge-coupled device (CCD) Raman spectroscopy was compared with near-infrared spectroscopy (NIR) in following hydrate formation of drugs during wet granulation (off-line). To perform an at-line process analysis, the effect of water addition was monitored by NIR spectroscopy and principal components analysis (PCA). The changes in the crystal arrangements were verified by using X-ray powder diffraction (XRPD).RESULTS: Hydrate formation of theophylline and caffeine could be followed by CCD Raman spectroscopy. The NIR and Raman spectroscopic results were consistent with each other. NIR revealed the state of water, and Raman spectroscopy gave information related to the drug molecule itself. The XRPD confirmed the spectroscopic results. PCA with three principal components explained 99.9 of the spectral variation in the second derivative NIR spectra.CONCLUSIONS: Both CCD Raman and NIR spectroscopic methods can be applied to monitoring of hydrate formation processes. However, NIR is more suitable for monitoring solid-water interactions.

KW - Multivariate Analysis

KW - Spectrum Analysis, Raman

KW - Technology, Pharmaceutical

KW - Wettability

KW - Wetting Agents

M3 - Journal article

C2 - 12403064

VL - 19

SP - 1285

EP - 1291

JO - Pharmaceutical Research

JF - Pharmaceutical Research

SN - 0724-8741

IS - 9

ER -

ID: 140623049