Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printing

Research output: Contribution to journalJournal articleResearchpeer-review

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Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printing. / Eleftheriadis, Georgios K.; Monou, Paraskevi Kyriaki; Bouropoulos, Nikolaos; Boetker, Johan; Rantanen, Jukka; Jacobsen, Jette; Vizirianakis, Ioannis S.; Fatouros, Dimitrios G.

In: Journal of Pharmaceutical Sciences, Vol. 109, No. 9, 2020, p. 2757-2766.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Eleftheriadis, GK, Monou, PK, Bouropoulos, N, Boetker, J, Rantanen, J, Jacobsen, J, Vizirianakis, IS & Fatouros, DG 2020, 'Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printing', Journal of Pharmaceutical Sciences, vol. 109, no. 9, pp. 2757-2766. https://doi.org/10.1016/j.xphs.2020.05.022

APA

Eleftheriadis, G. K., Monou, P. K., Bouropoulos, N., Boetker, J., Rantanen, J., Jacobsen, J., ... Fatouros, D. G. (2020). Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printing. Journal of Pharmaceutical Sciences, 109(9), 2757-2766. https://doi.org/10.1016/j.xphs.2020.05.022

Vancouver

Eleftheriadis GK, Monou PK, Bouropoulos N, Boetker J, Rantanen J, Jacobsen J et al. Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printing. Journal of Pharmaceutical Sciences. 2020;109(9):2757-2766. https://doi.org/10.1016/j.xphs.2020.05.022

Author

Eleftheriadis, Georgios K. ; Monou, Paraskevi Kyriaki ; Bouropoulos, Nikolaos ; Boetker, Johan ; Rantanen, Jukka ; Jacobsen, Jette ; Vizirianakis, Ioannis S. ; Fatouros, Dimitrios G. / Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printing. In: Journal of Pharmaceutical Sciences. 2020 ; Vol. 109, No. 9. pp. 2757-2766.

Bibtex

@article{300bfb4774da4f2599ba35f23435b1c3,
title = "Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printing",
abstract = "In the area of developing oromucosal drug delivery systems, mucoadhesive buccal films are the most promising formulations for either systemic or local drug delivery. The current study presents the fabrication of buccal films, by combining fused deposition modeling (FDM) and inkjet printing. Hydroxypropyl methylcellulose-based films were fabricated via FDM, containing the non-steroidal anti-inflammatory drug ketoprofen. Unidirectional release properties were achieved, by incorporating an ethyl cellulose-based backing layer. The local anesthetic lidocaine hydrochloride, combined with the permeation enhancer l-menthol, was deposited onto the film by inkjet printing. Physicochemical analysis showed alterations in the characteristics of the films, and the mucoadhesive and mechanical properties were effectively modified, due to the ink deposition on the substrates. The in vitro release data of the active pharmaceutical compounds, as well as the permeation profiles across ex vivo porcine buccal mucosa and filter-grown TR146 cells of human buccal origin, were associated with the presence of the permeation enhancer and the backing layer. The lack of any toxicity of the fabricated films was demonstrated by the MTT viability assay. This proof-of-concept study provides an alternative formulation approach of mucoadhesive buccal films, intended for the treatment of local oromucosal diseases or systemic drug delivery.",
keywords = "3D printing, Buccal, Controlled release, Epithelial permeability, Mucoadhesive, Mucosal delivery, Permeability enhancer, Transmucosal drug delivery",
author = "Eleftheriadis, {Georgios K.} and Monou, {Paraskevi Kyriaki} and Nikolaos Bouropoulos and Johan Boetker and Jukka Rantanen and Jette Jacobsen and Vizirianakis, {Ioannis S.} and Fatouros, {Dimitrios G.}",
year = "2020",
doi = "10.1016/j.xphs.2020.05.022",
language = "English",
volume = "109",
pages = "2757--2766",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "9",

}

RIS

TY - JOUR

T1 - Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printing

AU - Eleftheriadis, Georgios K.

AU - Monou, Paraskevi Kyriaki

AU - Bouropoulos, Nikolaos

AU - Boetker, Johan

AU - Rantanen, Jukka

AU - Jacobsen, Jette

AU - Vizirianakis, Ioannis S.

AU - Fatouros, Dimitrios G.

PY - 2020

Y1 - 2020

N2 - In the area of developing oromucosal drug delivery systems, mucoadhesive buccal films are the most promising formulations for either systemic or local drug delivery. The current study presents the fabrication of buccal films, by combining fused deposition modeling (FDM) and inkjet printing. Hydroxypropyl methylcellulose-based films were fabricated via FDM, containing the non-steroidal anti-inflammatory drug ketoprofen. Unidirectional release properties were achieved, by incorporating an ethyl cellulose-based backing layer. The local anesthetic lidocaine hydrochloride, combined with the permeation enhancer l-menthol, was deposited onto the film by inkjet printing. Physicochemical analysis showed alterations in the characteristics of the films, and the mucoadhesive and mechanical properties were effectively modified, due to the ink deposition on the substrates. The in vitro release data of the active pharmaceutical compounds, as well as the permeation profiles across ex vivo porcine buccal mucosa and filter-grown TR146 cells of human buccal origin, were associated with the presence of the permeation enhancer and the backing layer. The lack of any toxicity of the fabricated films was demonstrated by the MTT viability assay. This proof-of-concept study provides an alternative formulation approach of mucoadhesive buccal films, intended for the treatment of local oromucosal diseases or systemic drug delivery.

AB - In the area of developing oromucosal drug delivery systems, mucoadhesive buccal films are the most promising formulations for either systemic or local drug delivery. The current study presents the fabrication of buccal films, by combining fused deposition modeling (FDM) and inkjet printing. Hydroxypropyl methylcellulose-based films were fabricated via FDM, containing the non-steroidal anti-inflammatory drug ketoprofen. Unidirectional release properties were achieved, by incorporating an ethyl cellulose-based backing layer. The local anesthetic lidocaine hydrochloride, combined with the permeation enhancer l-menthol, was deposited onto the film by inkjet printing. Physicochemical analysis showed alterations in the characteristics of the films, and the mucoadhesive and mechanical properties were effectively modified, due to the ink deposition on the substrates. The in vitro release data of the active pharmaceutical compounds, as well as the permeation profiles across ex vivo porcine buccal mucosa and filter-grown TR146 cells of human buccal origin, were associated with the presence of the permeation enhancer and the backing layer. The lack of any toxicity of the fabricated films was demonstrated by the MTT viability assay. This proof-of-concept study provides an alternative formulation approach of mucoadhesive buccal films, intended for the treatment of local oromucosal diseases or systemic drug delivery.

KW - 3D printing

KW - Buccal

KW - Controlled release

KW - Epithelial permeability

KW - Mucoadhesive

KW - Mucosal delivery

KW - Permeability enhancer

KW - Transmucosal drug delivery

U2 - 10.1016/j.xphs.2020.05.022

DO - 10.1016/j.xphs.2020.05.022

M3 - Journal article

C2 - 32497597

AN - SCOPUS:85086326012

VL - 109

SP - 2757

EP - 2766

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 9

ER -

ID: 244325368