Exploring the Complexity of Processing-Induced Dehydration during Hot Melt Extrusion Using In-Line Raman Spectroscopy

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Standard

Exploring the Complexity of Processing-Induced Dehydration during Hot Melt Extrusion Using In-Line Raman Spectroscopy. / Arnfast, Lærke; van Renterghem, Jeroen; Aho, Johanna; Bøtker, Johan; Raijada, Dhara; Baldursdóttir, Stefania; De Beer, Thomas; Rantanen, Jukka.

In: Pharmaceutics, Vol. 12, No. 2, 116, 2020.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Arnfast, L, van Renterghem, J, Aho, J, Bøtker, J, Raijada, D, Baldursdóttir, S, De Beer, T & Rantanen, J 2020, 'Exploring the Complexity of Processing-Induced Dehydration during Hot Melt Extrusion Using In-Line Raman Spectroscopy', Pharmaceutics, vol. 12, no. 2, 116. https://doi.org/10.3390/pharmaceutics12020116

APA

Arnfast, L., van Renterghem, J., Aho, J., Bøtker, J., Raijada, D., Baldursdóttir, S., ... Rantanen, J. (2020). Exploring the Complexity of Processing-Induced Dehydration during Hot Melt Extrusion Using In-Line Raman Spectroscopy. Pharmaceutics, 12(2), [116]. https://doi.org/10.3390/pharmaceutics12020116

Vancouver

Arnfast L, van Renterghem J, Aho J, Bøtker J, Raijada D, Baldursdóttir S et al. Exploring the Complexity of Processing-Induced Dehydration during Hot Melt Extrusion Using In-Line Raman Spectroscopy. Pharmaceutics. 2020;12(2). 116. https://doi.org/10.3390/pharmaceutics12020116

Author

Arnfast, Lærke ; van Renterghem, Jeroen ; Aho, Johanna ; Bøtker, Johan ; Raijada, Dhara ; Baldursdóttir, Stefania ; De Beer, Thomas ; Rantanen, Jukka. / Exploring the Complexity of Processing-Induced Dehydration during Hot Melt Extrusion Using In-Line Raman Spectroscopy. In: Pharmaceutics. 2020 ; Vol. 12, No. 2.

Bibtex

@article{4fa2834d4081428b87fa69202cea0222,
title = "Exploring the Complexity of Processing-Induced Dehydration during Hot Melt Extrusion Using In-Line Raman Spectroscopy",
abstract = "The specific aim in this study was to understand the effect of critical process parameters on the solid form composition of model drug compounds during hot melt extrusion using in-line Raman spectroscopy combined with Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) modeling for semi-quantitative kinetic profiling. It was observed that the hydrate and anhydrate solid forms of two model drugs in the melts of nitrofurantoin (NF):polyethylene oxide (PEO) and piroxicam (PRX):PEO could be resolved from a MCR-ALS model without an external calibration dataset. Based on this model, the influence of two critical process parameters (shear and temperature) on the solid form composition could be evaluated in a real-time mode and the kinetics of complex transformation pathways could be explored. Additionally, the dehydration pathways of NF monohydrate and PRX monohydrate in molten PEO could be derived. It can be concluded that dehydration of both hydrates in PEO occurs via competing mechanisms—a solution-mediated transformation pathway and a solid–solid transformation, and that the balance between these mechanisms is determined by the combined effect of both temperature and shear. Another important observation was that the water released from these hydrate compounds has a detectable effect on the rheological characteristics of this mixture.",
author = "L{\ae}rke Arnfast and {van Renterghem}, Jeroen and Johanna Aho and Johan B{\o}tker and Dhara Raijada and Stefania Baldursd{\'o}ttir and {De Beer}, Thomas and Jukka Rantanen",
year = "2020",
doi = "10.3390/pharmaceutics12020116",
language = "English",
volume = "12",
journal = "Pharmaceutics",
issn = "1999-4923",
publisher = "MDPI AG",
number = "2",

}

RIS

TY - JOUR

T1 - Exploring the Complexity of Processing-Induced Dehydration during Hot Melt Extrusion Using In-Line Raman Spectroscopy

AU - Arnfast, Lærke

AU - van Renterghem, Jeroen

AU - Aho, Johanna

AU - Bøtker, Johan

AU - Raijada, Dhara

AU - Baldursdóttir, Stefania

AU - De Beer, Thomas

AU - Rantanen, Jukka

PY - 2020

Y1 - 2020

N2 - The specific aim in this study was to understand the effect of critical process parameters on the solid form composition of model drug compounds during hot melt extrusion using in-line Raman spectroscopy combined with Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) modeling for semi-quantitative kinetic profiling. It was observed that the hydrate and anhydrate solid forms of two model drugs in the melts of nitrofurantoin (NF):polyethylene oxide (PEO) and piroxicam (PRX):PEO could be resolved from a MCR-ALS model without an external calibration dataset. Based on this model, the influence of two critical process parameters (shear and temperature) on the solid form composition could be evaluated in a real-time mode and the kinetics of complex transformation pathways could be explored. Additionally, the dehydration pathways of NF monohydrate and PRX monohydrate in molten PEO could be derived. It can be concluded that dehydration of both hydrates in PEO occurs via competing mechanisms—a solution-mediated transformation pathway and a solid–solid transformation, and that the balance between these mechanisms is determined by the combined effect of both temperature and shear. Another important observation was that the water released from these hydrate compounds has a detectable effect on the rheological characteristics of this mixture.

AB - The specific aim in this study was to understand the effect of critical process parameters on the solid form composition of model drug compounds during hot melt extrusion using in-line Raman spectroscopy combined with Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) modeling for semi-quantitative kinetic profiling. It was observed that the hydrate and anhydrate solid forms of two model drugs in the melts of nitrofurantoin (NF):polyethylene oxide (PEO) and piroxicam (PRX):PEO could be resolved from a MCR-ALS model without an external calibration dataset. Based on this model, the influence of two critical process parameters (shear and temperature) on the solid form composition could be evaluated in a real-time mode and the kinetics of complex transformation pathways could be explored. Additionally, the dehydration pathways of NF monohydrate and PRX monohydrate in molten PEO could be derived. It can be concluded that dehydration of both hydrates in PEO occurs via competing mechanisms—a solution-mediated transformation pathway and a solid–solid transformation, and that the balance between these mechanisms is determined by the combined effect of both temperature and shear. Another important observation was that the water released from these hydrate compounds has a detectable effect on the rheological characteristics of this mixture.

U2 - 10.3390/pharmaceutics12020116

DO - 10.3390/pharmaceutics12020116

M3 - Journal article

C2 - 32024085

VL - 12

JO - Pharmaceutics

JF - Pharmaceutics

SN - 1999-4923

IS - 2

M1 - 116

ER -

ID: 235404089