Evaluation of ring shear testing as a characterization method for powder flow in small-scale powder processing equipment

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Evaluation of ring shear testing as a characterization method for powder flow in small-scale powder processing equipment. / Søgaard, Søren Vinter; Pedersen, Troels; Allesø, Morten; Garnaes, Joergen; Rantanen, Jukka.

In: International Journal of Pharmaceutics, Vol. 475, No. 1-2, 29.08.2014, p. 315-323.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Søgaard, SV, Pedersen, T, Allesø, M, Garnaes, J & Rantanen, J 2014, 'Evaluation of ring shear testing as a characterization method for powder flow in small-scale powder processing equipment', International Journal of Pharmaceutics, vol. 475, no. 1-2, pp. 315-323. https://doi.org/10.1016/j.ijpharm.2014.08.060

APA

Søgaard, S. V., Pedersen, T., Allesø, M., Garnaes, J., & Rantanen, J. (2014). Evaluation of ring shear testing as a characterization method for powder flow in small-scale powder processing equipment. International Journal of Pharmaceutics, 475(1-2), 315-323. https://doi.org/10.1016/j.ijpharm.2014.08.060

Vancouver

Søgaard SV, Pedersen T, Allesø M, Garnaes J, Rantanen J. Evaluation of ring shear testing as a characterization method for powder flow in small-scale powder processing equipment. International Journal of Pharmaceutics. 2014 Aug 29;475(1-2):315-323. https://doi.org/10.1016/j.ijpharm.2014.08.060

Author

Søgaard, Søren Vinter ; Pedersen, Troels ; Allesø, Morten ; Garnaes, Joergen ; Rantanen, Jukka. / Evaluation of ring shear testing as a characterization method for powder flow in small-scale powder processing equipment. In: International Journal of Pharmaceutics. 2014 ; Vol. 475, No. 1-2. pp. 315-323.

Bibtex

@article{fd5a2f7c9e3a47f185a2bdefb72ffff1,
title = "Evaluation of ring shear testing as a characterization method for powder flow in small-scale powder processing equipment",
abstract = "Powder flow in small-scale equipment is challenging to predict. To meet this need, the impact of consolidation during powder flow characterization, the level of consolidation existing during discharge of powders from a tablet press hopper and the uncertainty of shear and wall friction measurements at small consolidation stresses were investigated. For this purpose, three grades of microcrystalline cellulose were used. Results showed that powder flow properties depend strongly on the consolidation during testing. The consolidation during discharge in terms of the major principal stress and wall normal stress were approximately 200Pa and 114Pa, respectively, in the critical transition from the converging to the lower vertical section of the hopper. The lower limit of consolidation for the shear and wall friction test was approximately 500Pa and 200Pa, respectively. At this consolidation level, the wall and shear stress resolution influences the precision of the measured powder flow properties. This study highlights the need for an improved experimental setup which would be capable of measuring the flow properties of powders under very small consolidation stresses with a high shear stress resolution. This will allow the accuracy, precision and applicability of the shear test to be improved for pharmaceutical applications.",
author = "S{\o}gaard, {S{\o}ren Vinter} and Troels Pedersen and Morten Alles{\o} and Joergen Garnaes and Jukka Rantanen",
note = "Copyright {\circledC} 2014 Elsevier B.V. All rights reserved.",
year = "2014",
month = "8",
day = "29",
doi = "10.1016/j.ijpharm.2014.08.060",
language = "English",
volume = "475",
pages = "315--323",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Evaluation of ring shear testing as a characterization method for powder flow in small-scale powder processing equipment

AU - Søgaard, Søren Vinter

AU - Pedersen, Troels

AU - Allesø, Morten

AU - Garnaes, Joergen

AU - Rantanen, Jukka

N1 - Copyright © 2014 Elsevier B.V. All rights reserved.

PY - 2014/8/29

Y1 - 2014/8/29

N2 - Powder flow in small-scale equipment is challenging to predict. To meet this need, the impact of consolidation during powder flow characterization, the level of consolidation existing during discharge of powders from a tablet press hopper and the uncertainty of shear and wall friction measurements at small consolidation stresses were investigated. For this purpose, three grades of microcrystalline cellulose were used. Results showed that powder flow properties depend strongly on the consolidation during testing. The consolidation during discharge in terms of the major principal stress and wall normal stress were approximately 200Pa and 114Pa, respectively, in the critical transition from the converging to the lower vertical section of the hopper. The lower limit of consolidation for the shear and wall friction test was approximately 500Pa and 200Pa, respectively. At this consolidation level, the wall and shear stress resolution influences the precision of the measured powder flow properties. This study highlights the need for an improved experimental setup which would be capable of measuring the flow properties of powders under very small consolidation stresses with a high shear stress resolution. This will allow the accuracy, precision and applicability of the shear test to be improved for pharmaceutical applications.

AB - Powder flow in small-scale equipment is challenging to predict. To meet this need, the impact of consolidation during powder flow characterization, the level of consolidation existing during discharge of powders from a tablet press hopper and the uncertainty of shear and wall friction measurements at small consolidation stresses were investigated. For this purpose, three grades of microcrystalline cellulose were used. Results showed that powder flow properties depend strongly on the consolidation during testing. The consolidation during discharge in terms of the major principal stress and wall normal stress were approximately 200Pa and 114Pa, respectively, in the critical transition from the converging to the lower vertical section of the hopper. The lower limit of consolidation for the shear and wall friction test was approximately 500Pa and 200Pa, respectively. At this consolidation level, the wall and shear stress resolution influences the precision of the measured powder flow properties. This study highlights the need for an improved experimental setup which would be capable of measuring the flow properties of powders under very small consolidation stresses with a high shear stress resolution. This will allow the accuracy, precision and applicability of the shear test to be improved for pharmaceutical applications.

U2 - 10.1016/j.ijpharm.2014.08.060

DO - 10.1016/j.ijpharm.2014.08.060

M3 - Journal article

C2 - 25178826

VL - 475

SP - 315

EP - 323

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 123665724