Evaluation of ring shear testing as a characterization method for powder flow in small-scale powder processing equipment
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Evaluation of ring shear testing as a characterization method for powder flow in small-scale powder processing equipment. / Søgaard, Søren Vinter; Pedersen, Troels; Allesø, Morten; Garnaes, Joergen; Rantanen, Jukka.
In: International Journal of Pharmaceutics, Vol. 475, No. 1-2, 29.08.2014, p. 315-323.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Evaluation of ring shear testing as a characterization method for powder flow in small-scale powder processing equipment
AU - Søgaard, Søren Vinter
AU - Pedersen, Troels
AU - Allesø, Morten
AU - Garnaes, Joergen
AU - Rantanen, Jukka
N1 - Copyright © 2014 Elsevier B.V. All rights reserved.
PY - 2014/8/29
Y1 - 2014/8/29
N2 - Powder flow in small-scale equipment is challenging to predict. To meet this need, the impact of consolidation during powder flow characterization, the level of consolidation existing during discharge of powders from a tablet press hopper and the uncertainty of shear and wall friction measurements at small consolidation stresses were investigated. For this purpose, three grades of microcrystalline cellulose were used. Results showed that powder flow properties depend strongly on the consolidation during testing. The consolidation during discharge in terms of the major principal stress and wall normal stress were approximately 200Pa and 114Pa, respectively, in the critical transition from the converging to the lower vertical section of the hopper. The lower limit of consolidation for the shear and wall friction test was approximately 500Pa and 200Pa, respectively. At this consolidation level, the wall and shear stress resolution influences the precision of the measured powder flow properties. This study highlights the need for an improved experimental setup which would be capable of measuring the flow properties of powders under very small consolidation stresses with a high shear stress resolution. This will allow the accuracy, precision and applicability of the shear test to be improved for pharmaceutical applications.
AB - Powder flow in small-scale equipment is challenging to predict. To meet this need, the impact of consolidation during powder flow characterization, the level of consolidation existing during discharge of powders from a tablet press hopper and the uncertainty of shear and wall friction measurements at small consolidation stresses were investigated. For this purpose, three grades of microcrystalline cellulose were used. Results showed that powder flow properties depend strongly on the consolidation during testing. The consolidation during discharge in terms of the major principal stress and wall normal stress were approximately 200Pa and 114Pa, respectively, in the critical transition from the converging to the lower vertical section of the hopper. The lower limit of consolidation for the shear and wall friction test was approximately 500Pa and 200Pa, respectively. At this consolidation level, the wall and shear stress resolution influences the precision of the measured powder flow properties. This study highlights the need for an improved experimental setup which would be capable of measuring the flow properties of powders under very small consolidation stresses with a high shear stress resolution. This will allow the accuracy, precision and applicability of the shear test to be improved for pharmaceutical applications.
U2 - 10.1016/j.ijpharm.2014.08.060
DO - 10.1016/j.ijpharm.2014.08.060
M3 - Journal article
C2 - 25178826
VL - 475
SP - 315
EP - 323
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 1-2
ER -
ID: 123665724