Enzymatic characterization of lipid-based drug delivery systems

Research output: Contribution to journalJournal article

Standard

Enzymatic characterization of lipid-based drug delivery systems. / Ljusberg-Wahren, Helena; Seier Nielsen, Flemming; Brogård, Mattias; Troedsson, Emma; Müllertz, Anette.

In: Internation Journal of Pharmaceutics, Vol. 298, No. 2, 2005, p. 328-32.

Research output: Contribution to journalJournal article

Harvard

Ljusberg-Wahren, H, Seier Nielsen, F, Brogård, M, Troedsson, E & Müllertz, A 2005, 'Enzymatic characterization of lipid-based drug delivery systems', Internation Journal of Pharmaceutics, vol. 298, no. 2, pp. 328-32. https://doi.org/10.1016/j.ijpharm.2005.02.038

APA

Ljusberg-Wahren, H., Seier Nielsen, F., Brogård, M., Troedsson, E., & Müllertz, A. (2005). Enzymatic characterization of lipid-based drug delivery systems. Internation Journal of Pharmaceutics, 298(2), 328-32. https://doi.org/10.1016/j.ijpharm.2005.02.038

Vancouver

Ljusberg-Wahren H, Seier Nielsen F, Brogård M, Troedsson E, Müllertz A. Enzymatic characterization of lipid-based drug delivery systems. Internation Journal of Pharmaceutics. 2005;298(2):328-32. https://doi.org/10.1016/j.ijpharm.2005.02.038

Author

Ljusberg-Wahren, Helena ; Seier Nielsen, Flemming ; Brogård, Mattias ; Troedsson, Emma ; Müllertz, Anette. / Enzymatic characterization of lipid-based drug delivery systems. In: Internation Journal of Pharmaceutics. 2005 ; Vol. 298, No. 2. pp. 328-32.

Bibtex

@article{526eb8b0c5ea11dd9473000ea68e967b,
title = "Enzymatic characterization of lipid-based drug delivery systems",
abstract = "The present work introduces a simple and robust in vitro method for enzymatic characterisation of surface properties of lipid dispersions in aqueous media. The initial lipolysis rate in biorelevant media, using pancreatic lipase and a self-microemulsifying formulation (SMEDDS) containing digestible lipids as substrate, was determined. The impact of incorporating two sparingly water soluble model drugs, probucol and halofantrine, into the SMEDDS was studied. It was found that both model drugs reduced the initial rate of lipolysis compared with the vehicle, probucol having a larger effect than halofantrine. The reduction of initial lipolysis rate indicates that probucol and halofantrine are bound in the water/emulsion interface limiting the substrate availability.",
author = "Helena Ljusberg-Wahren and {Seier Nielsen}, Flemming and Mattias Brog{\aa}rd and Emma Troedsson and Anette M{\"u}llertz",
note = "Keywords: Animals; Biopharmaceutics; Drug Delivery Systems; Emulsions; Lipase; Lipids; Lipolysis; Pancreas; Particle Size; Phenanthrenes; Probucol; Swine",
year = "2005",
doi = "10.1016/j.ijpharm.2005.02.038",
language = "English",
volume = "298",
pages = "328--32",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Enzymatic characterization of lipid-based drug delivery systems

AU - Ljusberg-Wahren, Helena

AU - Seier Nielsen, Flemming

AU - Brogård, Mattias

AU - Troedsson, Emma

AU - Müllertz, Anette

N1 - Keywords: Animals; Biopharmaceutics; Drug Delivery Systems; Emulsions; Lipase; Lipids; Lipolysis; Pancreas; Particle Size; Phenanthrenes; Probucol; Swine

PY - 2005

Y1 - 2005

N2 - The present work introduces a simple and robust in vitro method for enzymatic characterisation of surface properties of lipid dispersions in aqueous media. The initial lipolysis rate in biorelevant media, using pancreatic lipase and a self-microemulsifying formulation (SMEDDS) containing digestible lipids as substrate, was determined. The impact of incorporating two sparingly water soluble model drugs, probucol and halofantrine, into the SMEDDS was studied. It was found that both model drugs reduced the initial rate of lipolysis compared with the vehicle, probucol having a larger effect than halofantrine. The reduction of initial lipolysis rate indicates that probucol and halofantrine are bound in the water/emulsion interface limiting the substrate availability.

AB - The present work introduces a simple and robust in vitro method for enzymatic characterisation of surface properties of lipid dispersions in aqueous media. The initial lipolysis rate in biorelevant media, using pancreatic lipase and a self-microemulsifying formulation (SMEDDS) containing digestible lipids as substrate, was determined. The impact of incorporating two sparingly water soluble model drugs, probucol and halofantrine, into the SMEDDS was studied. It was found that both model drugs reduced the initial rate of lipolysis compared with the vehicle, probucol having a larger effect than halofantrine. The reduction of initial lipolysis rate indicates that probucol and halofantrine are bound in the water/emulsion interface limiting the substrate availability.

U2 - 10.1016/j.ijpharm.2005.02.038

DO - 10.1016/j.ijpharm.2005.02.038

M3 - Journal article

C2 - 15979260

VL - 298

SP - 328

EP - 332

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 2

ER -

ID: 9012768