Emerging trends in the stabilization of amorphous drugs

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Emerging trends in the stabilization of amorphous drugs. / Laitinen, Riikka; Löbmann, Korbinian; Strachan, Clare J.; Grohganz, Holger; Rades, Thomas.

In: International Journal of Pharmaceutics, Vol. 453, No. 1, 30.08.2013, p. 65-79.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Laitinen, R, Löbmann, K, Strachan, CJ, Grohganz, H & Rades, T 2013, 'Emerging trends in the stabilization of amorphous drugs', International Journal of Pharmaceutics, vol. 453, no. 1, pp. 65-79. https://doi.org/10.1016/j.ijpharm.2012.04.066

APA

Laitinen, R., Löbmann, K., Strachan, C. J., Grohganz, H., & Rades, T. (2013). Emerging trends in the stabilization of amorphous drugs. International Journal of Pharmaceutics, 453(1), 65-79. https://doi.org/10.1016/j.ijpharm.2012.04.066

Vancouver

Laitinen R, Löbmann K, Strachan CJ, Grohganz H, Rades T. Emerging trends in the stabilization of amorphous drugs. International Journal of Pharmaceutics. 2013 Aug 30;453(1):65-79. https://doi.org/10.1016/j.ijpharm.2012.04.066

Author

Laitinen, Riikka ; Löbmann, Korbinian ; Strachan, Clare J. ; Grohganz, Holger ; Rades, Thomas. / Emerging trends in the stabilization of amorphous drugs. In: International Journal of Pharmaceutics. 2013 ; Vol. 453, No. 1. pp. 65-79.

Bibtex

@article{2c021c3f53fd4f1792ace872d0a976f3,

title = "Emerging trends in the stabilization of amorphous drugs",

abstract = "The number of active pharmaceutical substances having high therapeutic potential but low water solubility is constantly increasing, making it difficult to formulate these compounds as oral dosage forms. The solubility and dissolution rate, and thus potentially the bioavailability, of these poorly water-soluble drugs can be increased by the formation of stabilized amorphous forms. Currently, formulation as solid polymer dispersions is the preferred method to enhance drug dissolution and to stabilize the amorphous form of a drug. The purpose of this review is to highlight emerging alternative methods to amorphous polymer dispersions for stabilizing the amorphous form of drugs. First, an overview of the properties and stabilization mechanisms of amorphous forms is provided. Subsequently, formulation approaches such as the preparation of co-amorphous small-molecule mixtures and the use of mesoporous silicon and silica-based carriers are presented as potential means to increase the stability of amorphous pharmaceuticals.",

author = "Riikka Laitinen and Korbinian L{\"o}bmann and Strachan, {Clare J.} and Holger Grohganz and Thomas Rades",

year = "2013",

month = aug,

day = "30",

doi = "10.1016/j.ijpharm.2012.04.066",

language = "English",

volume = "453",

pages = "65--79",

journal = "International Journal of Pharmaceutics",

issn = "0378-5173",

publisher = "Elsevier",

number = "1",

}

RIS

TY - JOUR

T1 - Emerging trends in the stabilization of amorphous drugs

AU - Laitinen, Riikka

AU - Löbmann, Korbinian

AU - Strachan, Clare J.

AU - Grohganz, Holger

AU - Rades, Thomas

PY - 2013/8/30

Y1 - 2013/8/30

N2 - The number of active pharmaceutical substances having high therapeutic potential but low water solubility is constantly increasing, making it difficult to formulate these compounds as oral dosage forms. The solubility and dissolution rate, and thus potentially the bioavailability, of these poorly water-soluble drugs can be increased by the formation of stabilized amorphous forms. Currently, formulation as solid polymer dispersions is the preferred method to enhance drug dissolution and to stabilize the amorphous form of a drug. The purpose of this review is to highlight emerging alternative methods to amorphous polymer dispersions for stabilizing the amorphous form of drugs. First, an overview of the properties and stabilization mechanisms of amorphous forms is provided. Subsequently, formulation approaches such as the preparation of co-amorphous small-molecule mixtures and the use of mesoporous silicon and silica-based carriers are presented as potential means to increase the stability of amorphous pharmaceuticals.

AB - The number of active pharmaceutical substances having high therapeutic potential but low water solubility is constantly increasing, making it difficult to formulate these compounds as oral dosage forms. The solubility and dissolution rate, and thus potentially the bioavailability, of these poorly water-soluble drugs can be increased by the formation of stabilized amorphous forms. Currently, formulation as solid polymer dispersions is the preferred method to enhance drug dissolution and to stabilize the amorphous form of a drug. The purpose of this review is to highlight emerging alternative methods to amorphous polymer dispersions for stabilizing the amorphous form of drugs. First, an overview of the properties and stabilization mechanisms of amorphous forms is provided. Subsequently, formulation approaches such as the preparation of co-amorphous small-molecule mixtures and the use of mesoporous silicon and silica-based carriers are presented as potential means to increase the stability of amorphous pharmaceuticals.

U2 - 10.1016/j.ijpharm.2012.04.066

DO - 10.1016/j.ijpharm.2012.04.066

M3 - Journal article

C2 - 22569230

VL - 453

SP - 65

EP - 79

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1

ER -

ID: 49459260