Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length
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Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length. / Feltrin, Kate L; Little, Tanya J; Meyer, James H; Horowitz, Michael; Smout, Andre J P M; Wishart, Judith; Pilichiewicz, Amelia N; Rades, Thomas; Chapman, Ian M; Feinle-Bisset, Christine.
In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Vol. 287, No. 3, 09.2004, p. R524-33.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length
AU - Feltrin, Kate L
AU - Little, Tanya J
AU - Meyer, James H
AU - Horowitz, Michael
AU - Smout, Andre J P M
AU - Wishart, Judith
AU - Pilichiewicz, Amelia N
AU - Rades, Thomas
AU - Chapman, Ian M
AU - Feinle-Bisset, Christine
PY - 2004/9
Y1 - 2004/9
N2 - The gastrointestinal effects of intraluminal fats may be critically dependent on the chain length of fatty acids released during lipolysis. We postulated that intraduodenal administration of lauric acid (12 carbon atoms; C12) would suppress appetite, modulate antropyloroduodenal pressure waves (PWs), and stimulate the release of cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) more than an identical dose of decanoic acid (10 carbon atoms; C10). Eight healthy males (19-47 yr old) were studied on three occasions in a double-blind, randomized fashion. Appetite perceptions, antropyloroduodenal PWs, and plasma CCK and GLP-1 concentrations were measured during a 90-min intraduodenal infusion of 1) C12, 2) C10, or 3) control (rate: 2 ml/min, 0.375 kcal/min for C12/C10). Energy intake at a buffet meal, immediately after completion of the infusion, was also quantified. C12, but not C10, suppressed appetite perceptions (P <0.001) and energy intake (control: 4,604 +/- 464 kJ, C10: 4,109 +/- 588 kJ, and C12: 1,747 +/- 632 kJ; P <0.001, C12 vs. control/C10). C12, but not C10, also induced nausea (P <0.001). C12 stimulated basal pyloric pressures and isolated pyloric PWs and suppressed antral and duodenal PWs compared with control (P <0.05 for all). C10 transiently stimulated isolated pyloric PWs (P = 0.001) and had no effect on antral PWs but markedly stimulated duodenal PWs (P = 0.004). C12 and C10 increased plasma CCK (P <0.001), but the effect of C12 was substantially greater (P = 0.001); C12 stimulated GLP-1 (P <0.05), whereas C10 did not. In conclusion, there are major differences in the effects of intraduodenal C12 and C10, administered at 0.375 kcal/min, on appetite, energy intake, antropyloroduodenal PWs, and gut hormone release in humans.
AB - The gastrointestinal effects of intraluminal fats may be critically dependent on the chain length of fatty acids released during lipolysis. We postulated that intraduodenal administration of lauric acid (12 carbon atoms; C12) would suppress appetite, modulate antropyloroduodenal pressure waves (PWs), and stimulate the release of cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) more than an identical dose of decanoic acid (10 carbon atoms; C10). Eight healthy males (19-47 yr old) were studied on three occasions in a double-blind, randomized fashion. Appetite perceptions, antropyloroduodenal PWs, and plasma CCK and GLP-1 concentrations were measured during a 90-min intraduodenal infusion of 1) C12, 2) C10, or 3) control (rate: 2 ml/min, 0.375 kcal/min for C12/C10). Energy intake at a buffet meal, immediately after completion of the infusion, was also quantified. C12, but not C10, suppressed appetite perceptions (P <0.001) and energy intake (control: 4,604 +/- 464 kJ, C10: 4,109 +/- 588 kJ, and C12: 1,747 +/- 632 kJ; P <0.001, C12 vs. control/C10). C12, but not C10, also induced nausea (P <0.001). C12 stimulated basal pyloric pressures and isolated pyloric PWs and suppressed antral and duodenal PWs compared with control (P <0.05 for all). C10 transiently stimulated isolated pyloric PWs (P = 0.001) and had no effect on antral PWs but markedly stimulated duodenal PWs (P = 0.004). C12 and C10 increased plasma CCK (P <0.001), but the effect of C12 was substantially greater (P = 0.001); C12 stimulated GLP-1 (P <0.05), whereas C10 did not. In conclusion, there are major differences in the effects of intraduodenal C12 and C10, administered at 0.375 kcal/min, on appetite, energy intake, antropyloroduodenal PWs, and gut hormone release in humans.
KW - Adult
KW - Appetite
KW - Cholecystokinin
KW - Decanoic Acids
KW - Double-Blind Method
KW - Duodenum
KW - Energy Intake
KW - Fatty Acids
KW - Gastrointestinal Motility
KW - Glucagon
KW - Glucagon-Like Peptide 1
KW - Hormones
KW - Humans
KW - Infusions, Parenteral
KW - Lauric Acids
KW - Male
KW - Manometry
KW - Middle Aged
KW - Peptide Fragments
KW - Pilot Projects
KW - Pressure
KW - Protein Precursors
KW - Pyloric Antrum
KW - Pylorus
KW - Sensation
U2 - 10.1152/ajpregu.00039.2004
DO - 10.1152/ajpregu.00039.2004
M3 - Journal article
C2 - 15166004
VL - 287
SP - R524-33
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6119
IS - 3
ER -
ID: 46408741