Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length

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Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length. / Feltrin, Kate L; Little, Tanya J; Meyer, James H; Horowitz, Michael; Smout, Andre J P M; Wishart, Judith; Pilichiewicz, Amelia N; Rades, Thomas; Chapman, Ian M; Feinle-Bisset, Christine.

In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Vol. 287, No. 3, 09.2004, p. R524-33.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Feltrin, KL, Little, TJ, Meyer, JH, Horowitz, M, Smout, AJPM, Wishart, J, Pilichiewicz, AN, Rades, T, Chapman, IM & Feinle-Bisset, C 2004, 'Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol. 287, no. 3, pp. R524-33. https://doi.org/10.1152/ajpregu.00039.2004

APA

Feltrin, K. L., Little, T. J., Meyer, J. H., Horowitz, M., Smout, A. J. P. M., Wishart, J., Pilichiewicz, A. N., Rades, T., Chapman, I. M., & Feinle-Bisset, C. (2004). Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 287(3), R524-33. https://doi.org/10.1152/ajpregu.00039.2004

Vancouver

Feltrin KL, Little TJ, Meyer JH, Horowitz M, Smout AJPM, Wishart J et al. Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 2004 Sep;287(3):R524-33. https://doi.org/10.1152/ajpregu.00039.2004

Author

Feltrin, Kate L ; Little, Tanya J ; Meyer, James H ; Horowitz, Michael ; Smout, Andre J P M ; Wishart, Judith ; Pilichiewicz, Amelia N ; Rades, Thomas ; Chapman, Ian M ; Feinle-Bisset, Christine. / Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length. In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 2004 ; Vol. 287, No. 3. pp. R524-33.

Bibtex

@article{69570194e68f4c8787091cb8170e2cce,
title = "Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length",
abstract = "The gastrointestinal effects of intraluminal fats may be critically dependent on the chain length of fatty acids released during lipolysis. We postulated that intraduodenal administration of lauric acid (12 carbon atoms; C12) would suppress appetite, modulate antropyloroduodenal pressure waves (PWs), and stimulate the release of cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) more than an identical dose of decanoic acid (10 carbon atoms; C10). Eight healthy males (19-47 yr old) were studied on three occasions in a double-blind, randomized fashion. Appetite perceptions, antropyloroduodenal PWs, and plasma CCK and GLP-1 concentrations were measured during a 90-min intraduodenal infusion of 1) C12, 2) C10, or 3) control (rate: 2 ml/min, 0.375 kcal/min for C12/C10). Energy intake at a buffet meal, immediately after completion of the infusion, was also quantified. C12, but not C10, suppressed appetite perceptions (P <0.001) and energy intake (control: 4,604 +/- 464 kJ, C10: 4,109 +/- 588 kJ, and C12: 1,747 +/- 632 kJ; P <0.001, C12 vs. control/C10). C12, but not C10, also induced nausea (P <0.001). C12 stimulated basal pyloric pressures and isolated pyloric PWs and suppressed antral and duodenal PWs compared with control (P <0.05 for all). C10 transiently stimulated isolated pyloric PWs (P = 0.001) and had no effect on antral PWs but markedly stimulated duodenal PWs (P = 0.004). C12 and C10 increased plasma CCK (P <0.001), but the effect of C12 was substantially greater (P = 0.001); C12 stimulated GLP-1 (P <0.05), whereas C10 did not. In conclusion, there are major differences in the effects of intraduodenal C12 and C10, administered at 0.375 kcal/min, on appetite, energy intake, antropyloroduodenal PWs, and gut hormone release in humans.",
keywords = "Adult, Appetite, Cholecystokinin, Decanoic Acids, Double-Blind Method, Duodenum, Energy Intake, Fatty Acids, Gastrointestinal Motility, Glucagon, Glucagon-Like Peptide 1, Hormones, Humans, Infusions, Parenteral, Lauric Acids, Male, Manometry, Middle Aged, Peptide Fragments, Pilot Projects, Pressure, Protein Precursors, Pyloric Antrum, Pylorus, Sensation",
author = "Feltrin, {Kate L} and Little, {Tanya J} and Meyer, {James H} and Michael Horowitz and Smout, {Andre J P M} and Judith Wishart and Pilichiewicz, {Amelia N} and Thomas Rades and Chapman, {Ian M} and Christine Feinle-Bisset",
year = "2004",
month = sep,
doi = "10.1152/ajpregu.00039.2004",
language = "English",
volume = "287",
pages = "R524--33",
journal = "American Journal of Physiology: Regulatory, Integrative and Comparative Physiology",
issn = "0363-6119",
publisher = "American Physiological Society",
number = "3",

}

RIS

TY - JOUR

T1 - Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length

AU - Feltrin, Kate L

AU - Little, Tanya J

AU - Meyer, James H

AU - Horowitz, Michael

AU - Smout, Andre J P M

AU - Wishart, Judith

AU - Pilichiewicz, Amelia N

AU - Rades, Thomas

AU - Chapman, Ian M

AU - Feinle-Bisset, Christine

PY - 2004/9

Y1 - 2004/9

N2 - The gastrointestinal effects of intraluminal fats may be critically dependent on the chain length of fatty acids released during lipolysis. We postulated that intraduodenal administration of lauric acid (12 carbon atoms; C12) would suppress appetite, modulate antropyloroduodenal pressure waves (PWs), and stimulate the release of cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) more than an identical dose of decanoic acid (10 carbon atoms; C10). Eight healthy males (19-47 yr old) were studied on three occasions in a double-blind, randomized fashion. Appetite perceptions, antropyloroduodenal PWs, and plasma CCK and GLP-1 concentrations were measured during a 90-min intraduodenal infusion of 1) C12, 2) C10, or 3) control (rate: 2 ml/min, 0.375 kcal/min for C12/C10). Energy intake at a buffet meal, immediately after completion of the infusion, was also quantified. C12, but not C10, suppressed appetite perceptions (P <0.001) and energy intake (control: 4,604 +/- 464 kJ, C10: 4,109 +/- 588 kJ, and C12: 1,747 +/- 632 kJ; P <0.001, C12 vs. control/C10). C12, but not C10, also induced nausea (P <0.001). C12 stimulated basal pyloric pressures and isolated pyloric PWs and suppressed antral and duodenal PWs compared with control (P <0.05 for all). C10 transiently stimulated isolated pyloric PWs (P = 0.001) and had no effect on antral PWs but markedly stimulated duodenal PWs (P = 0.004). C12 and C10 increased plasma CCK (P <0.001), but the effect of C12 was substantially greater (P = 0.001); C12 stimulated GLP-1 (P <0.05), whereas C10 did not. In conclusion, there are major differences in the effects of intraduodenal C12 and C10, administered at 0.375 kcal/min, on appetite, energy intake, antropyloroduodenal PWs, and gut hormone release in humans.

AB - The gastrointestinal effects of intraluminal fats may be critically dependent on the chain length of fatty acids released during lipolysis. We postulated that intraduodenal administration of lauric acid (12 carbon atoms; C12) would suppress appetite, modulate antropyloroduodenal pressure waves (PWs), and stimulate the release of cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) more than an identical dose of decanoic acid (10 carbon atoms; C10). Eight healthy males (19-47 yr old) were studied on three occasions in a double-blind, randomized fashion. Appetite perceptions, antropyloroduodenal PWs, and plasma CCK and GLP-1 concentrations were measured during a 90-min intraduodenal infusion of 1) C12, 2) C10, or 3) control (rate: 2 ml/min, 0.375 kcal/min for C12/C10). Energy intake at a buffet meal, immediately after completion of the infusion, was also quantified. C12, but not C10, suppressed appetite perceptions (P <0.001) and energy intake (control: 4,604 +/- 464 kJ, C10: 4,109 +/- 588 kJ, and C12: 1,747 +/- 632 kJ; P <0.001, C12 vs. control/C10). C12, but not C10, also induced nausea (P <0.001). C12 stimulated basal pyloric pressures and isolated pyloric PWs and suppressed antral and duodenal PWs compared with control (P <0.05 for all). C10 transiently stimulated isolated pyloric PWs (P = 0.001) and had no effect on antral PWs but markedly stimulated duodenal PWs (P = 0.004). C12 and C10 increased plasma CCK (P <0.001), but the effect of C12 was substantially greater (P = 0.001); C12 stimulated GLP-1 (P <0.05), whereas C10 did not. In conclusion, there are major differences in the effects of intraduodenal C12 and C10, administered at 0.375 kcal/min, on appetite, energy intake, antropyloroduodenal PWs, and gut hormone release in humans.

KW - Adult

KW - Appetite

KW - Cholecystokinin

KW - Decanoic Acids

KW - Double-Blind Method

KW - Duodenum

KW - Energy Intake

KW - Fatty Acids

KW - Gastrointestinal Motility

KW - Glucagon

KW - Glucagon-Like Peptide 1

KW - Hormones

KW - Humans

KW - Infusions, Parenteral

KW - Lauric Acids

KW - Male

KW - Manometry

KW - Middle Aged

KW - Peptide Fragments

KW - Pilot Projects

KW - Pressure

KW - Protein Precursors

KW - Pyloric Antrum

KW - Pylorus

KW - Sensation

U2 - 10.1152/ajpregu.00039.2004

DO - 10.1152/ajpregu.00039.2004

M3 - Journal article

C2 - 15166004

VL - 287

SP - R524-33

JO - American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

JF - American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

SN - 0363-6119

IS - 3

ER -

ID: 46408741