Effect of excipients on encapsulation and release of insulin from spray-dried solid lipid microparticles

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Standard

Effect of excipients on encapsulation and release of insulin from spray-dried solid lipid microparticles. / Wu, Chengyu; van de Weert, Marco; Baldursdottir, Stefania G; Yang, Mingshi; Mu, Huiling.

In: International Journal of Pharmaceutics, Vol. 550, No. 1-2, 06.09.2018, p. 439-446.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Wu, C, van de Weert, M, Baldursdottir, SG, Yang, M & Mu, H 2018, 'Effect of excipients on encapsulation and release of insulin from spray-dried solid lipid microparticles', International Journal of Pharmaceutics, vol. 550, no. 1-2, pp. 439-446. https://doi.org/10.1016/j.ijpharm.2018.09.007

APA

Wu, C., van de Weert, M., Baldursdottir, S. G., Yang, M., & Mu, H. (2018). Effect of excipients on encapsulation and release of insulin from spray-dried solid lipid microparticles. International Journal of Pharmaceutics, 550(1-2), 439-446. https://doi.org/10.1016/j.ijpharm.2018.09.007

Vancouver

Wu C, van de Weert M, Baldursdottir SG, Yang M, Mu H. Effect of excipients on encapsulation and release of insulin from spray-dried solid lipid microparticles. International Journal of Pharmaceutics. 2018 Sep 6;550(1-2):439-446. https://doi.org/10.1016/j.ijpharm.2018.09.007

Author

Wu, Chengyu ; van de Weert, Marco ; Baldursdottir, Stefania G ; Yang, Mingshi ; Mu, Huiling. / Effect of excipients on encapsulation and release of insulin from spray-dried solid lipid microparticles. In: International Journal of Pharmaceutics. 2018 ; Vol. 550, No. 1-2. pp. 439-446.

Bibtex

@article{3a9553a263a34affba4cda144682a097,
title = "Effect of excipients on encapsulation and release of insulin from spray-dried solid lipid microparticles",
abstract = "The study aimed at investigating the potential of spray drying method for encapsulation of protein drugs into solid lipid microparticles (MP) and evaluating effects of excipients on encapsulation and release of protein from MP. After transformation of model protein insulin to insulin-phospholipid complex, it was dissolved together with lipid excipients in organic solvent, which was spray-dried to form solid lipid MP. Polymeric MP with D, L-lactic-co-glycolic acid (PLGA) were prepared similarly. Around 90{\%} of insulin was encapsulated in glycerol monostearate MP and glycerol distearate MP, whereas the encapsulation efficiency was 60{\%} and 35{\%} for tristearate (TG18) MP and tribehenate (TG22) MP, respectively. The secondary structure of insulin in the spray-dried MP was substantially similar to that of the insulin control solution, suggesting that only minor alterations occurred during the spray drying process. Sustained release of insulin was observed from both TG18 MP and TG22 MP. The burst release of insulin from TG18 MP and TG22 MP was around 30{\%} and 10{\%}, respectively, which was significantly lower than that from PLGA MP (40{\%}). In conclusion, spray drying a solution containing both lipids and protein-phospholipid complex is a promising method for encapsulating protein into solid lipid MP, which can be used for sustained delivery of protein drugs.",
author = "Chengyu Wu and {van de Weert}, Marco and Baldursdottir, {Stefania G} and Mingshi Yang and Huiling Mu",
note = "Copyright {\circledC} 2018. Published by Elsevier B.V.",
year = "2018",
month = "9",
day = "6",
doi = "10.1016/j.ijpharm.2018.09.007",
language = "English",
volume = "550",
pages = "439--446",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Effect of excipients on encapsulation and release of insulin from spray-dried solid lipid microparticles

AU - Wu, Chengyu

AU - van de Weert, Marco

AU - Baldursdottir, Stefania G

AU - Yang, Mingshi

AU - Mu, Huiling

N1 - Copyright © 2018. Published by Elsevier B.V.

PY - 2018/9/6

Y1 - 2018/9/6

N2 - The study aimed at investigating the potential of spray drying method for encapsulation of protein drugs into solid lipid microparticles (MP) and evaluating effects of excipients on encapsulation and release of protein from MP. After transformation of model protein insulin to insulin-phospholipid complex, it was dissolved together with lipid excipients in organic solvent, which was spray-dried to form solid lipid MP. Polymeric MP with D, L-lactic-co-glycolic acid (PLGA) were prepared similarly. Around 90% of insulin was encapsulated in glycerol monostearate MP and glycerol distearate MP, whereas the encapsulation efficiency was 60% and 35% for tristearate (TG18) MP and tribehenate (TG22) MP, respectively. The secondary structure of insulin in the spray-dried MP was substantially similar to that of the insulin control solution, suggesting that only minor alterations occurred during the spray drying process. Sustained release of insulin was observed from both TG18 MP and TG22 MP. The burst release of insulin from TG18 MP and TG22 MP was around 30% and 10%, respectively, which was significantly lower than that from PLGA MP (40%). In conclusion, spray drying a solution containing both lipids and protein-phospholipid complex is a promising method for encapsulating protein into solid lipid MP, which can be used for sustained delivery of protein drugs.

AB - The study aimed at investigating the potential of spray drying method for encapsulation of protein drugs into solid lipid microparticles (MP) and evaluating effects of excipients on encapsulation and release of protein from MP. After transformation of model protein insulin to insulin-phospholipid complex, it was dissolved together with lipid excipients in organic solvent, which was spray-dried to form solid lipid MP. Polymeric MP with D, L-lactic-co-glycolic acid (PLGA) were prepared similarly. Around 90% of insulin was encapsulated in glycerol monostearate MP and glycerol distearate MP, whereas the encapsulation efficiency was 60% and 35% for tristearate (TG18) MP and tribehenate (TG22) MP, respectively. The secondary structure of insulin in the spray-dried MP was substantially similar to that of the insulin control solution, suggesting that only minor alterations occurred during the spray drying process. Sustained release of insulin was observed from both TG18 MP and TG22 MP. The burst release of insulin from TG18 MP and TG22 MP was around 30% and 10%, respectively, which was significantly lower than that from PLGA MP (40%). In conclusion, spray drying a solution containing both lipids and protein-phospholipid complex is a promising method for encapsulating protein into solid lipid MP, which can be used for sustained delivery of protein drugs.

U2 - 10.1016/j.ijpharm.2018.09.007

DO - 10.1016/j.ijpharm.2018.09.007

M3 - Journal article

C2 - 30196139

VL - 550

SP - 439

EP - 446

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 202196956