Drug nanocrystallisation within liposomes

Research output: Contribution to journal › Review › Research › peer-review

Standard

Drug nanocrystallisation within liposomes. / Li, Tang; Cipolla, David; Rades, Thomas; Boyd, Ben J.

In: Journal of Controlled Release, Vol. 288, 2018, p. 96-110.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Li, T, Cipolla, D, Rades, T & Boyd, BJ 2018, 'Drug nanocrystallisation within liposomes', Journal of Controlled Release, vol. 288, pp. 96-110. https://doi.org/10.1016/j.jconrel.2018.09.001

APA

Li, T., Cipolla, D., Rades, T., & Boyd, B. J. (2018). Drug nanocrystallisation within liposomes. Journal of Controlled Release, 288, 96-110. https://doi.org/10.1016/j.jconrel.2018.09.001

Vancouver

Li T, Cipolla D, Rades T, Boyd BJ. Drug nanocrystallisation within liposomes. Journal of Controlled Release. 2018;288:96-110. https://doi.org/10.1016/j.jconrel.2018.09.001

Author

Li, Tang ; Cipolla, David ; Rades, Thomas ; Boyd, Ben J. / Drug nanocrystallisation within liposomes. In: Journal of Controlled Release. 2018 ; Vol. 288. pp. 96-110.

Bibtex

@article{4d71c01cd539447cbef8109434b05a93,
title = "Drug nanocrystallisation within liposomes",
abstract = "Liposomes are phospholipid bilayer vesicles that have been explored in pharmaceutical research as drug delivery systems for >50 years. Despite being important to their morphology and drug release pattern, the physical state of the drug within liposomes (liquid, solid, crystalline form) is often overlooked. This review focuses on precipitation of drug within liposomes, which can result in the formation of confined nanocrystals, and consequent changes in liposome morphology and drug release patterns. The type of drugs that form nanocrystals within liposomes, preparation and characterisation of liposomal drug nanocrystals, and the in vitro drug release behaviour from these systems are communicated, with a discussion of their potential as drug delivery systems.",
keywords = "Liposomes, Nanocrystal, Polymorph, Precipitation, Solid state",
author = "Tang Li and David Cipolla and Thomas Rades and Boyd, {Ben J.}",
year = "2018",
doi = "10.1016/j.jconrel.2018.09.001",
language = "English",
volume = "288",
pages = "96--110",
journal = "Journal of Controlled Release",
issn = "0168-3659",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Drug nanocrystallisation within liposomes

AU - Li, Tang

AU - Cipolla, David

AU - Rades, Thomas

AU - Boyd, Ben J.

PY - 2018

Y1 - 2018

N2 - Liposomes are phospholipid bilayer vesicles that have been explored in pharmaceutical research as drug delivery systems for >50 years. Despite being important to their morphology and drug release pattern, the physical state of the drug within liposomes (liquid, solid, crystalline form) is often overlooked. This review focuses on precipitation of drug within liposomes, which can result in the formation of confined nanocrystals, and consequent changes in liposome morphology and drug release patterns. The type of drugs that form nanocrystals within liposomes, preparation and characterisation of liposomal drug nanocrystals, and the in vitro drug release behaviour from these systems are communicated, with a discussion of their potential as drug delivery systems.

AB - Liposomes are phospholipid bilayer vesicles that have been explored in pharmaceutical research as drug delivery systems for >50 years. Despite being important to their morphology and drug release pattern, the physical state of the drug within liposomes (liquid, solid, crystalline form) is often overlooked. This review focuses on precipitation of drug within liposomes, which can result in the formation of confined nanocrystals, and consequent changes in liposome morphology and drug release patterns. The type of drugs that form nanocrystals within liposomes, preparation and characterisation of liposomal drug nanocrystals, and the in vitro drug release behaviour from these systems are communicated, with a discussion of their potential as drug delivery systems.

KW - Liposomes

KW - Nanocrystal

KW - Polymorph

KW - Precipitation

KW - Solid state

U2 - 10.1016/j.jconrel.2018.09.001

DO - 10.1016/j.jconrel.2018.09.001

M3 - Review

C2 - 30184465

AN - SCOPUS:85052954296

VL - 288

SP - 96

EP - 110

JO - Journal of Controlled Release

JF - Journal of Controlled Release

SN - 0168-3659

ER -

ID: 220851030