Direct Measurement of Lateral Molecular Diffusivity on the Surface of Supersaturated Amorphous Solid Dispersions by Atomic Force Microscopy

Research output: Contribution to journalJournal articlepeer-review

Standard

Direct Measurement of Lateral Molecular Diffusivity on the Surface of Supersaturated Amorphous Solid Dispersions by Atomic Force Microscopy. / Bannow, Jacob; Karl, Maximilian; Larsen, Peter Emil; Hwu, En Te; Rades, Thomas.

In: Molecular Pharmaceutics, Vol. 17, No. 5, 2020, p. 1715-1722.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Bannow, J, Karl, M, Larsen, PE, Hwu, ET & Rades, T 2020, 'Direct Measurement of Lateral Molecular Diffusivity on the Surface of Supersaturated Amorphous Solid Dispersions by Atomic Force Microscopy', Molecular Pharmaceutics, vol. 17, no. 5, pp. 1715-1722. https://doi.org/10.1021/acs.molpharmaceut.0c00176

APA

Bannow, J., Karl, M., Larsen, P. E., Hwu, E. T., & Rades, T. (2020). Direct Measurement of Lateral Molecular Diffusivity on the Surface of Supersaturated Amorphous Solid Dispersions by Atomic Force Microscopy. Molecular Pharmaceutics, 17(5), 1715-1722. https://doi.org/10.1021/acs.molpharmaceut.0c00176

Vancouver

Bannow J, Karl M, Larsen PE, Hwu ET, Rades T. Direct Measurement of Lateral Molecular Diffusivity on the Surface of Supersaturated Amorphous Solid Dispersions by Atomic Force Microscopy. Molecular Pharmaceutics. 2020;17(5):1715-1722. https://doi.org/10.1021/acs.molpharmaceut.0c00176

Author

Bannow, Jacob ; Karl, Maximilian ; Larsen, Peter Emil ; Hwu, En Te ; Rades, Thomas. / Direct Measurement of Lateral Molecular Diffusivity on the Surface of Supersaturated Amorphous Solid Dispersions by Atomic Force Microscopy. In: Molecular Pharmaceutics. 2020 ; Vol. 17, No. 5. pp. 1715-1722.

Bibtex

@article{cbe2221118fe407c9f3678cd4a747c71,
title = "Direct Measurement of Lateral Molecular Diffusivity on the Surface of Supersaturated Amorphous Solid Dispersions by Atomic Force Microscopy",
abstract = "Quantifying molecular surface diffusivity is of broad interest in many different fields of science and technology. In this study, the method of surface grating decay is utilized to investigate the surface diffusion of practical relevant amorphous solid dispersions of indomethacin and the polymeric excipient Soluplus (a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer) at various polymer concentrations (1 20% w/w). The study confirms that measuring surface diffusivity below the system's glass transition temperature is possible with a simplified atomic force microscopy setup. Results highlight a striking polymer influence on the surface diffusivity of drug molecules at low polymer concentrations and a turnover point to a polymer dominated diffusion at around three percent (w/w) polymer concentration. The surface diffusion measurements further correlate well with the observed increase in physical stability of the system as measured by X-ray powder diffraction. These findings are of vital interest in both the applied use and fundamental understanding of amorphous solid dispersions.",
keywords = "surface mobility, amorphous solid dispersion (ASD), atomic force microscopy (AFM), molecular surface diffusivity, indomethacin, soluplus, grating decay, GLASS-TRANSITION TEMPERATURE, PHYSICAL STABILITY, SELF-DIFFUSION, O-TERPHENYL, INDOMETHACIN, CRYSTALLIZATION, SOLUBILITY, BEHAVIOR, STATE, POLY(VINYLPYRROLIDONE)",
author = "Jacob Bannow and Maximilian Karl and Larsen, {Peter Emil} and Hwu, {En Te} and Thomas Rades",
year = "2020",
doi = "10.1021/acs.molpharmaceut.0c00176",
language = "English",
volume = "17",
pages = "1715--1722",
journal = "Molecular Pharmaceutics",
issn = "1543-8384",
publisher = "American Chemical Society",
number = "5",

}

RIS

TY - JOUR

T1 - Direct Measurement of Lateral Molecular Diffusivity on the Surface of Supersaturated Amorphous Solid Dispersions by Atomic Force Microscopy

AU - Bannow, Jacob

AU - Karl, Maximilian

AU - Larsen, Peter Emil

AU - Hwu, En Te

AU - Rades, Thomas

PY - 2020

Y1 - 2020

N2 - Quantifying molecular surface diffusivity is of broad interest in many different fields of science and technology. In this study, the method of surface grating decay is utilized to investigate the surface diffusion of practical relevant amorphous solid dispersions of indomethacin and the polymeric excipient Soluplus (a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer) at various polymer concentrations (1 20% w/w). The study confirms that measuring surface diffusivity below the system's glass transition temperature is possible with a simplified atomic force microscopy setup. Results highlight a striking polymer influence on the surface diffusivity of drug molecules at low polymer concentrations and a turnover point to a polymer dominated diffusion at around three percent (w/w) polymer concentration. The surface diffusion measurements further correlate well with the observed increase in physical stability of the system as measured by X-ray powder diffraction. These findings are of vital interest in both the applied use and fundamental understanding of amorphous solid dispersions.

AB - Quantifying molecular surface diffusivity is of broad interest in many different fields of science and technology. In this study, the method of surface grating decay is utilized to investigate the surface diffusion of practical relevant amorphous solid dispersions of indomethacin and the polymeric excipient Soluplus (a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer) at various polymer concentrations (1 20% w/w). The study confirms that measuring surface diffusivity below the system's glass transition temperature is possible with a simplified atomic force microscopy setup. Results highlight a striking polymer influence on the surface diffusivity of drug molecules at low polymer concentrations and a turnover point to a polymer dominated diffusion at around three percent (w/w) polymer concentration. The surface diffusion measurements further correlate well with the observed increase in physical stability of the system as measured by X-ray powder diffraction. These findings are of vital interest in both the applied use and fundamental understanding of amorphous solid dispersions.

KW - surface mobility

KW - amorphous solid dispersion (ASD)

KW - atomic force microscopy (AFM)

KW - molecular surface diffusivity

KW - indomethacin

KW - soluplus

KW - grating decay

KW - GLASS-TRANSITION TEMPERATURE

KW - PHYSICAL STABILITY

KW - SELF-DIFFUSION

KW - O-TERPHENYL

KW - INDOMETHACIN

KW - CRYSTALLIZATION

KW - SOLUBILITY

KW - BEHAVIOR

KW - STATE

KW - POLY(VINYLPYRROLIDONE)

U2 - 10.1021/acs.molpharmaceut.0c00176

DO - 10.1021/acs.molpharmaceut.0c00176

M3 - Journal article

C2 - 32207959

VL - 17

SP - 1715

EP - 1722

JO - Molecular Pharmaceutics

JF - Molecular Pharmaceutics

SN - 1543-8384

IS - 5

ER -

ID: 246318464