Development of Self-Nanoemulsifying Drug Delivery Systems Containing 4-Allylpyrocatechol for Treatment of Oral Infections Caused by Candida albicans

Research output: Contribution to journalJournal articlepeer-review

Standard

Development of Self-Nanoemulsifying Drug Delivery Systems Containing 4-Allylpyrocatechol for Treatment of Oral Infections Caused by Candida albicans. / Okonogi, Siriporn; Phumat, Pimpak; Khongkhunthian, Sakornrat; Chaijareenont, Pisaisit; Rades, Thomas; Mullertz, Anette.

In: Pharmaceutics, Vol. 13, No. 2, 167, 2021.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Okonogi, S, Phumat, P, Khongkhunthian, S, Chaijareenont, P, Rades, T & Mullertz, A 2021, 'Development of Self-Nanoemulsifying Drug Delivery Systems Containing 4-Allylpyrocatechol for Treatment of Oral Infections Caused by Candida albicans', Pharmaceutics, vol. 13, no. 2, 167. https://doi.org/10.3390/pharmaceutics13020167

APA

Okonogi, S., Phumat, P., Khongkhunthian, S., Chaijareenont, P., Rades, T., & Mullertz, A. (2021). Development of Self-Nanoemulsifying Drug Delivery Systems Containing 4-Allylpyrocatechol for Treatment of Oral Infections Caused by Candida albicans. Pharmaceutics, 13(2), [167]. https://doi.org/10.3390/pharmaceutics13020167

Vancouver

Okonogi S, Phumat P, Khongkhunthian S, Chaijareenont P, Rades T, Mullertz A. Development of Self-Nanoemulsifying Drug Delivery Systems Containing 4-Allylpyrocatechol for Treatment of Oral Infections Caused by Candida albicans. Pharmaceutics. 2021;13(2). 167. https://doi.org/10.3390/pharmaceutics13020167

Author

Okonogi, Siriporn ; Phumat, Pimpak ; Khongkhunthian, Sakornrat ; Chaijareenont, Pisaisit ; Rades, Thomas ; Mullertz, Anette. / Development of Self-Nanoemulsifying Drug Delivery Systems Containing 4-Allylpyrocatechol for Treatment of Oral Infections Caused by Candida albicans. In: Pharmaceutics. 2021 ; Vol. 13, No. 2.

Bibtex

@article{e9e366070a0c4b0cbf31229473a25335,
title = "Development of Self-Nanoemulsifying Drug Delivery Systems Containing 4-Allylpyrocatechol for Treatment of Oral Infections Caused by Candida albicans",
abstract = "Clinical use of 4-Allylpyrocatechol (APC), a potential antifungal agent from Piper betle, is limited because of its low water solubility. The current study explores the development of the self-nanoemulsifying drug delivery system (SNEDDS) containing APC (APC-SNEDDS) to enhance APC solubility. Results demonstrated that excipient type and concentration played an important role in the solubility of APC in the obtained SNEEDS. SNEDDS, comprising 20% Miglyol 812N, 30% Maisine 35-1, 40% Kolliphor RH40, and 10% absolute ethanol, provided the highest loading capacity and significantly increased water solubility of APC. Oil-in-water nanoemulsions (NE) with droplet sizes of less than 40 nm and a narrow size distribution were obtained after dispersing this APC-SNEDDS in water. The droplets had a negative zeta potential between -10 and -20 mV. The release kinetics of APC from APC-SNEDDS followed the Higuchi model. The NE containing 1.6 mg APC/mL had effective activity against Candida albicans with dose-dependent killing kinetics and was nontoxic to normal cells. The antifungal potential was similar to that of 1 mg nystatin/mL. These findings suggest that APC-SNEDDS are a useful system to enhance the apparent water solubility of APC and are a promising system for clinical treatment of oral infection caused by C. albicans.",
keywords = "SNEDDS, 4-allylpyrocatechol, solubility enhancement, antifungal activity, oral infections, Candida albicans",
author = "Siriporn Okonogi and Pimpak Phumat and Sakornrat Khongkhunthian and Pisaisit Chaijareenont and Thomas Rades and Anette Mullertz",
year = "2021",
doi = "10.3390/pharmaceutics13020167",
language = "English",
volume = "13",
journal = "Pharmaceutics",
issn = "1999-4923",
publisher = "MDPI AG",
number = "2",

}

RIS

TY - JOUR

T1 - Development of Self-Nanoemulsifying Drug Delivery Systems Containing 4-Allylpyrocatechol for Treatment of Oral Infections Caused by Candida albicans

AU - Okonogi, Siriporn

AU - Phumat, Pimpak

AU - Khongkhunthian, Sakornrat

AU - Chaijareenont, Pisaisit

AU - Rades, Thomas

AU - Mullertz, Anette

PY - 2021

Y1 - 2021

N2 - Clinical use of 4-Allylpyrocatechol (APC), a potential antifungal agent from Piper betle, is limited because of its low water solubility. The current study explores the development of the self-nanoemulsifying drug delivery system (SNEDDS) containing APC (APC-SNEDDS) to enhance APC solubility. Results demonstrated that excipient type and concentration played an important role in the solubility of APC in the obtained SNEEDS. SNEDDS, comprising 20% Miglyol 812N, 30% Maisine 35-1, 40% Kolliphor RH40, and 10% absolute ethanol, provided the highest loading capacity and significantly increased water solubility of APC. Oil-in-water nanoemulsions (NE) with droplet sizes of less than 40 nm and a narrow size distribution were obtained after dispersing this APC-SNEDDS in water. The droplets had a negative zeta potential between -10 and -20 mV. The release kinetics of APC from APC-SNEDDS followed the Higuchi model. The NE containing 1.6 mg APC/mL had effective activity against Candida albicans with dose-dependent killing kinetics and was nontoxic to normal cells. The antifungal potential was similar to that of 1 mg nystatin/mL. These findings suggest that APC-SNEDDS are a useful system to enhance the apparent water solubility of APC and are a promising system for clinical treatment of oral infection caused by C. albicans.

AB - Clinical use of 4-Allylpyrocatechol (APC), a potential antifungal agent from Piper betle, is limited because of its low water solubility. The current study explores the development of the self-nanoemulsifying drug delivery system (SNEDDS) containing APC (APC-SNEDDS) to enhance APC solubility. Results demonstrated that excipient type and concentration played an important role in the solubility of APC in the obtained SNEEDS. SNEDDS, comprising 20% Miglyol 812N, 30% Maisine 35-1, 40% Kolliphor RH40, and 10% absolute ethanol, provided the highest loading capacity and significantly increased water solubility of APC. Oil-in-water nanoemulsions (NE) with droplet sizes of less than 40 nm and a narrow size distribution were obtained after dispersing this APC-SNEDDS in water. The droplets had a negative zeta potential between -10 and -20 mV. The release kinetics of APC from APC-SNEDDS followed the Higuchi model. The NE containing 1.6 mg APC/mL had effective activity against Candida albicans with dose-dependent killing kinetics and was nontoxic to normal cells. The antifungal potential was similar to that of 1 mg nystatin/mL. These findings suggest that APC-SNEDDS are a useful system to enhance the apparent water solubility of APC and are a promising system for clinical treatment of oral infection caused by C. albicans.

KW - SNEDDS

KW - 4-allylpyrocatechol

KW - solubility enhancement

KW - antifungal activity

KW - oral infections

KW - Candida albicans

U2 - 10.3390/pharmaceutics13020167

DO - 10.3390/pharmaceutics13020167

M3 - Journal article

C2 - 33513803

VL - 13

JO - Pharmaceutics

JF - Pharmaceutics

SN - 1999-4923

IS - 2

M1 - 167

ER -

ID: 261215616