Development of an automation system for a tablet coater

Research output: Contribution to journalJournal articlepeer-review

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Development of an automation system for a tablet coater. / Ruotsalainen, Mirja; Heinämäki, Jyrki; Rantanen, Jukka; Yliruusi, Jouko.

In: AAPS PharmSciTech, Vol. 3, No. 2, 2002, p. E14.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Ruotsalainen, M, Heinämäki, J, Rantanen, J & Yliruusi, J 2002, 'Development of an automation system for a tablet coater', AAPS PharmSciTech, vol. 3, no. 2, pp. E14. https://doi.org/10.1208/pt030214

APA

Ruotsalainen, M., Heinämäki, J., Rantanen, J., & Yliruusi, J. (2002). Development of an automation system for a tablet coater. AAPS PharmSciTech, 3(2), E14. https://doi.org/10.1208/pt030214

Vancouver

Ruotsalainen M, Heinämäki J, Rantanen J, Yliruusi J. Development of an automation system for a tablet coater. AAPS PharmSciTech. 2002;3(2):E14. https://doi.org/10.1208/pt030214

Author

Ruotsalainen, Mirja ; Heinämäki, Jyrki ; Rantanen, Jukka ; Yliruusi, Jouko. / Development of an automation system for a tablet coater. In: AAPS PharmSciTech. 2002 ; Vol. 3, No. 2. pp. E14.

Bibtex

@article{8d0260c1565940e79a81d63375cb30b2,
title = "Development of an automation system for a tablet coater",
abstract = "An instrumentation and automation system for a side-vented pan coater with a novel air-flow rate measurement system for monitoring the film-coating process of tablets was designed and tested. The instrumented coating system was tested and validated by film-coating over 20 pilot-scale batches of tablets with aqueous-based hydroxypropyl methylcellulose (HPMC). Thirteen different process parameters were continuously measured and monitored, and the most significant ones were logged for analysis. Laser profilometry was used to measure the surface roughness of the coated tablets. The instrumentation system provided comprehensive and quantitative information on the process parameters monitored. The measured process parameters and the responses of the film-coated tablet batches showed that the coating process is reproducible. The inlet air-flow rate influenced the coating process and the subsequent quality of the coated tablets. Increasing the inlet flow rate accelerated the drying of the tablet surface. At high inlet flow rate, obvious film-coating defects (ie, unacceptable surface roughness of the coated tablets) were observed and the loss of coating material increased. The instrumented and automated pan-coating system described, including historical data storage capability and a novel air-flow measurement system, is a useful tool for controlling and characterizing the tablet film-coating process. Monitoring of critical process parameters increases the overall coating process efficiency and predictability.",
keywords = "Automation, Calibration, Chemistry, Pharmaceutical, Drug Compounding, Environment, Controlled, Hardness Tests, Pharmaceutical Preparations, Reproducibility of Results, Surface Properties, Tablets, Enteric-Coated, Technology, Pharmaceutical",
author = "Mirja Ruotsalainen and Jyrki Hein{\"a}m{\"a}ki and Jukka Rantanen and Jouko Yliruusi",
year = "2002",
doi = "10.1208/pt030214",
language = "English",
volume = "3",
pages = "E14",
journal = "AAPS PharmSciTech",
issn = "1530-9932",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Development of an automation system for a tablet coater

AU - Ruotsalainen, Mirja

AU - Heinämäki, Jyrki

AU - Rantanen, Jukka

AU - Yliruusi, Jouko

PY - 2002

Y1 - 2002

N2 - An instrumentation and automation system for a side-vented pan coater with a novel air-flow rate measurement system for monitoring the film-coating process of tablets was designed and tested. The instrumented coating system was tested and validated by film-coating over 20 pilot-scale batches of tablets with aqueous-based hydroxypropyl methylcellulose (HPMC). Thirteen different process parameters were continuously measured and monitored, and the most significant ones were logged for analysis. Laser profilometry was used to measure the surface roughness of the coated tablets. The instrumentation system provided comprehensive and quantitative information on the process parameters monitored. The measured process parameters and the responses of the film-coated tablet batches showed that the coating process is reproducible. The inlet air-flow rate influenced the coating process and the subsequent quality of the coated tablets. Increasing the inlet flow rate accelerated the drying of the tablet surface. At high inlet flow rate, obvious film-coating defects (ie, unacceptable surface roughness of the coated tablets) were observed and the loss of coating material increased. The instrumented and automated pan-coating system described, including historical data storage capability and a novel air-flow measurement system, is a useful tool for controlling and characterizing the tablet film-coating process. Monitoring of critical process parameters increases the overall coating process efficiency and predictability.

AB - An instrumentation and automation system for a side-vented pan coater with a novel air-flow rate measurement system for monitoring the film-coating process of tablets was designed and tested. The instrumented coating system was tested and validated by film-coating over 20 pilot-scale batches of tablets with aqueous-based hydroxypropyl methylcellulose (HPMC). Thirteen different process parameters were continuously measured and monitored, and the most significant ones were logged for analysis. Laser profilometry was used to measure the surface roughness of the coated tablets. The instrumentation system provided comprehensive and quantitative information on the process parameters monitored. The measured process parameters and the responses of the film-coated tablet batches showed that the coating process is reproducible. The inlet air-flow rate influenced the coating process and the subsequent quality of the coated tablets. Increasing the inlet flow rate accelerated the drying of the tablet surface. At high inlet flow rate, obvious film-coating defects (ie, unacceptable surface roughness of the coated tablets) were observed and the loss of coating material increased. The instrumented and automated pan-coating system described, including historical data storage capability and a novel air-flow measurement system, is a useful tool for controlling and characterizing the tablet film-coating process. Monitoring of critical process parameters increases the overall coating process efficiency and predictability.

KW - Automation

KW - Calibration

KW - Chemistry, Pharmaceutical

KW - Drug Compounding

KW - Environment, Controlled

KW - Hardness Tests

KW - Pharmaceutical Preparations

KW - Reproducibility of Results

KW - Surface Properties

KW - Tablets, Enteric-Coated

KW - Technology, Pharmaceutical

U2 - 10.1208/pt030214

DO - 10.1208/pt030214

M3 - Journal article

C2 - 12916951

VL - 3

SP - E14

JO - AAPS PharmSciTech

JF - AAPS PharmSciTech

SN - 1530-9932

IS - 2

ER -

ID: 140622257