Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation

Research output: Contribution to journalJournal articleCommunication

Standard

Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation. / Karl, Maximilian; Rantanen, Jukka; Rades, Thomas.

In: Pharmaceutics, Vol. 11, No. 12, 670, 06.12.2019.

Research output: Contribution to journalJournal articleCommunication

Harvard

Karl, M, Rantanen, J & Rades, T 2019, 'Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation', Pharmaceutics, vol. 11, no. 12, 670. https://doi.org/10.3390/pharmaceutics11120670

APA

Karl, M., Rantanen, J., & Rades, T. (2019). Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation. Pharmaceutics, 11(12), [670]. https://doi.org/10.3390/pharmaceutics11120670

Vancouver

Karl M, Rantanen J, Rades T. Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation. Pharmaceutics. 2019 Dec 6;11(12). 670. https://doi.org/10.3390/pharmaceutics11120670

Author

Karl, Maximilian ; Rantanen, Jukka ; Rades, Thomas. / Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation. In: Pharmaceutics. 2019 ; Vol. 11, No. 12.

Bibtex

@article{c747f6c8092141d4889d09bddcfd3de4,
title = "Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation",
abstract = "Thermal conductivity is a material specific property, which influences many aspects of pharmaceutical development, such as processing, modelling, analysis, and the development of novel formulation approaches. We have presented a method to measure thermal conductivity of small molecule organic glasses, based on a vacuum molding sample preparation technique combined with modulated differential scanning calorimetry. The method is applied to the two amorphous model compounds indomethacin and celecoxib. The measured values of below 0.2 W/m °C indicate very low thermal conductivity of the amorphous compounds, within the range of organic liquids and low conducting polymers.",
author = "Maximilian Karl and Jukka Rantanen and Thomas Rades",
year = "2019",
month = "12",
day = "6",
doi = "10.3390/pharmaceutics11120670",
language = "English",
volume = "11",
journal = "Pharmaceutics",
issn = "1999-4923",
publisher = "MDPI AG",
number = "12",

}

RIS

TY - JOUR

T1 - Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation

AU - Karl, Maximilian

AU - Rantanen, Jukka

AU - Rades, Thomas

PY - 2019/12/6

Y1 - 2019/12/6

N2 - Thermal conductivity is a material specific property, which influences many aspects of pharmaceutical development, such as processing, modelling, analysis, and the development of novel formulation approaches. We have presented a method to measure thermal conductivity of small molecule organic glasses, based on a vacuum molding sample preparation technique combined with modulated differential scanning calorimetry. The method is applied to the two amorphous model compounds indomethacin and celecoxib. The measured values of below 0.2 W/m °C indicate very low thermal conductivity of the amorphous compounds, within the range of organic liquids and low conducting polymers.

AB - Thermal conductivity is a material specific property, which influences many aspects of pharmaceutical development, such as processing, modelling, analysis, and the development of novel formulation approaches. We have presented a method to measure thermal conductivity of small molecule organic glasses, based on a vacuum molding sample preparation technique combined with modulated differential scanning calorimetry. The method is applied to the two amorphous model compounds indomethacin and celecoxib. The measured values of below 0.2 W/m °C indicate very low thermal conductivity of the amorphous compounds, within the range of organic liquids and low conducting polymers.

U2 - 10.3390/pharmaceutics11120670

DO - 10.3390/pharmaceutics11120670

M3 - Journal article

C2 - 31835607

VL - 11

JO - Pharmaceutics

JF - Pharmaceutics

SN - 1999-4923

IS - 12

M1 - 670

ER -

ID: 232073552