Dehydration studies using a novel multichamber microscale fluid bed dryer with in-line near-infrared measurement
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Dehydration studies using a novel multichamber microscale fluid bed dryer with in-line near-infrared measurement. / Räsänen, Eetu; Rantanen, Jukka; Mannermaa, Jukka-Pekka; Yliruusi, Jouko; Vuorela, Heikki.
In: Journal of Pharmaceutical Sciences, Vol. 92, No. 10, 10.2003, p. 2074-81.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dehydration studies using a novel multichamber microscale fluid bed dryer with in-line near-infrared measurement
AU - Räsänen, Eetu
AU - Rantanen, Jukka
AU - Mannermaa, Jukka-Pekka
AU - Yliruusi, Jouko
AU - Vuorela, Heikki
N1 - Copyright 2003 Wiley-Liss, Inc. and the American Pharmacists Association
PY - 2003/10
Y1 - 2003/10
N2 - The purpose of this research was to study the effect of two process parameters (temperature and moisture content) on dehydration behavior of different materials using a novel multichamber microscale fluid bed dryer with a process air control unit and in-line near-infrared (NIR) spectroscopy. The materials studied were disodium hydrogen phosphates with three different levels of hydrate water and wet theophylline granules. Measured process parameters of fluid bed drying were logged, including in-line NIR signals. Off-line analyses consisted of X-ray powder diffraction patterns, Fourier transform NIR spectra and moisture contents of studied materials. During fluid bed drying, the stepwise dehydration of materials was observed by the water content difference of inlet and outlet air, the pressure difference over the bed, and the in-line NIR spectroscopy. The off-line analysis confirmed the state of solid materials. The temperature and the moisture content of the process air were demonstrated to be significant factors for the solid-state stability of theophylline. The presented setup is a material and cost-saving approach for studying the influence of different process parameters on dehydration behavior during pharmaceutical processing.
AB - The purpose of this research was to study the effect of two process parameters (temperature and moisture content) on dehydration behavior of different materials using a novel multichamber microscale fluid bed dryer with a process air control unit and in-line near-infrared (NIR) spectroscopy. The materials studied were disodium hydrogen phosphates with three different levels of hydrate water and wet theophylline granules. Measured process parameters of fluid bed drying were logged, including in-line NIR signals. Off-line analyses consisted of X-ray powder diffraction patterns, Fourier transform NIR spectra and moisture contents of studied materials. During fluid bed drying, the stepwise dehydration of materials was observed by the water content difference of inlet and outlet air, the pressure difference over the bed, and the in-line NIR spectroscopy. The off-line analysis confirmed the state of solid materials. The temperature and the moisture content of the process air were demonstrated to be significant factors for the solid-state stability of theophylline. The presented setup is a material and cost-saving approach for studying the influence of different process parameters on dehydration behavior during pharmaceutical processing.
KW - Desiccation
KW - Humidity
KW - Powder Diffraction
KW - Powders
KW - Spectroscopy, Fourier Transform Infrared
KW - Spectroscopy, Near-Infrared
KW - Technology, Pharmaceutical
KW - Temperature
KW - Theophylline
KW - Time Factors
KW - Water
U2 - 10.1002/jps.10456
DO - 10.1002/jps.10456
M3 - Journal article
C2 - 14502546
VL - 92
SP - 2074
EP - 2081
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
SN - 0022-3549
IS - 10
ER -
ID: 140623155