Dairy-derived emulsifiers in infant formula show marginal effects on the plasma lipid profile and brain structure in preterm piglets relative to soy lecithin
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Dairy-derived emulsifiers in infant formula show marginal effects on the plasma lipid profile and brain structure in preterm piglets relative to soy lecithin. / Henriksen, Nicole L.; Aasmul-Olsen, Karoline; Venkatasubramanian, Ramakrishnan; Nygaard, Mikkel K.E.; Sprenger, Richard R.; Heckmann, Anne B.; Ostenfeld, Marie S.; Ejsing, Christer S.; Eskildsen, Simon F.; Müllertz, Anette; Sangild, Per T.; Bering, Stine B.; Thymann, Thomas.
In: Nutrients, Vol. 13, No. 3, 718, 2021, p. 1-18.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dairy-derived emulsifiers in infant formula show marginal effects on the plasma lipid profile and brain structure in preterm piglets relative to soy lecithin
AU - Henriksen, Nicole L.
AU - Aasmul-Olsen, Karoline
AU - Venkatasubramanian, Ramakrishnan
AU - Nygaard, Mikkel K.E.
AU - Sprenger, Richard R.
AU - Heckmann, Anne B.
AU - Ostenfeld, Marie S.
AU - Ejsing, Christer S.
AU - Eskildsen, Simon F.
AU - Müllertz, Anette
AU - Sangild, Per T.
AU - Bering, Stine B.
AU - Thymann, Thomas
PY - 2021
Y1 - 2021
N2 - Breastfed infants have higher intestinal lipid absorption and neurodevelopmental outcomes compared to formula-fed infants, which may relate to a different surface layer structure of fat globules in infant formula. This study investigated if dairy-derived emulsifiers increased lipid absorption and neurodevelopment relative to soy lecithin in newborn preterm piglets. Piglets received a formula diet containing soy lecithin (SL) or whey protein concentrate enriched in extracellular vesicles (WPC-A-EV) or phospholipids (WPC-PL) for 19 days. Both WPC-A-EV and WPC-PL emulsions, but not the intact diets, increased in vitro lipolysis compared to SL. The main differences of plasma lipidomics analysis were increased levels of some sphingolipids, and lipid molecules with odd-chain (17:1, 19:1, 19:3) as well as mono-and polyunsaturated fatty acyl chains (16:1, 20:1, 20:3) in the WPC-A-EV and WPC-PL groups and increased 18:2 fatty acyls in the SL group. Indirect monitoring of intestinal triacylglycerol absorption showed no differences between groups. Diffusor tensor imaging measurements of mean diffusivity in the hippocampus were lower for WPC-A-EV and WPC-PL groups compared to SL indicating improved hippocampal maturation. No differences in hippocampal lipid composition or short-term memory were observed between groups. In conclu-sion, emulsification of fat globules in infant formula with dairy-derived emulsifiers altered the plasma lipid profile and hippocampal tissue diffusivity but had limited effects on other absorptive and learning abilities relative to SL in preterm piglets.
AB - Breastfed infants have higher intestinal lipid absorption and neurodevelopmental outcomes compared to formula-fed infants, which may relate to a different surface layer structure of fat globules in infant formula. This study investigated if dairy-derived emulsifiers increased lipid absorption and neurodevelopment relative to soy lecithin in newborn preterm piglets. Piglets received a formula diet containing soy lecithin (SL) or whey protein concentrate enriched in extracellular vesicles (WPC-A-EV) or phospholipids (WPC-PL) for 19 days. Both WPC-A-EV and WPC-PL emulsions, but not the intact diets, increased in vitro lipolysis compared to SL. The main differences of plasma lipidomics analysis were increased levels of some sphingolipids, and lipid molecules with odd-chain (17:1, 19:1, 19:3) as well as mono-and polyunsaturated fatty acyl chains (16:1, 20:1, 20:3) in the WPC-A-EV and WPC-PL groups and increased 18:2 fatty acyls in the SL group. Indirect monitoring of intestinal triacylglycerol absorption showed no differences between groups. Diffusor tensor imaging measurements of mean diffusivity in the hippocampus were lower for WPC-A-EV and WPC-PL groups compared to SL indicating improved hippocampal maturation. No differences in hippocampal lipid composition or short-term memory were observed between groups. In conclu-sion, emulsification of fat globules in infant formula with dairy-derived emulsifiers altered the plasma lipid profile and hippocampal tissue diffusivity but had limited effects on other absorptive and learning abilities relative to SL in preterm piglets.
KW - Bovine whey phospholipids
KW - Brain
KW - Emulsification
KW - Extracellular vesicles
KW - Infant formula
KW - Milk fat globule membrane
KW - Neurodevelopment
KW - Piglet
KW - Polar lipids
KW - Preterm
U2 - 10.3390/nu13030718
DO - 10.3390/nu13030718
M3 - Journal article
C2 - 33668360
AN - SCOPUS:85101297893
VL - 13
SP - 1
EP - 18
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 3
M1 - 718
ER -
ID: 257874769