Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

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Current challenges and future perspectives in oral absorption research : An opinion of the UNGAP network. / Vinarov, Zahari; Abrahamsson, Bertil; Artursson, Per; Batchelor, Hannah; Berben, Philippe; Bernkop-Schnurch, Andreas; Butler, James; Ceulemans, Jens; Davies, Nigel; Dupont, Didier; Flaten, Goril Eide; Fotaki, Nikoletta; Griffin, Brendan T.; Jannin, Vincent; Keemink, Janneke; Kesisoglou, Filippos; Koziolek, Mirko; Kuentz, Martin; Mackie, Alan; Melendez-Martinez, Antonio J.; McAllister, Mark; Mullertz, Anette; O'Driscoll, Caitriona M.; Parrott, Neil; Paszkowska, Jadwiga; Pavek, Petr; Porter, Christopher J. H.; Reppas, Christos; Stillhart, Cordula; Sugano, Kiyohiko; Toader, Elena; Valentova, Katerina; Vertzoni, Maria; De Wildt, Saskia N.; Wilson, Clive G.; Augustijns, Patrick.

In: Advanced Drug Delivery Reviews, Vol. 171, 2021, p. 289-331.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Vinarov, Z, Abrahamsson, B, Artursson, P, Batchelor, H, Berben, P, Bernkop-Schnurch, A, Butler, J, Ceulemans, J, Davies, N, Dupont, D, Flaten, GE, Fotaki, N, Griffin, BT, Jannin, V, Keemink, J, Kesisoglou, F, Koziolek, M, Kuentz, M, Mackie, A, Melendez-Martinez, AJ, McAllister, M, Mullertz, A, O'Driscoll, CM, Parrott, N, Paszkowska, J, Pavek, P, Porter, CJH, Reppas, C, Stillhart, C, Sugano, K, Toader, E, Valentova, K, Vertzoni, M, De Wildt, SN, Wilson, CG & Augustijns, P 2021, 'Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network', Advanced Drug Delivery Reviews, vol. 171, pp. 289-331. https://doi.org/10.1016/j.addr.2021.02.001

APA

Vinarov, Z., Abrahamsson, B., Artursson, P., Batchelor, H., Berben, P., Bernkop-Schnurch, A., Butler, J., Ceulemans, J., Davies, N., Dupont, D., Flaten, G. E., Fotaki, N., Griffin, B. T., Jannin, V., Keemink, J., Kesisoglou, F., Koziolek, M., Kuentz, M., Mackie, A., ... Augustijns, P. (2021). Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network. Advanced Drug Delivery Reviews, 171, 289-331. https://doi.org/10.1016/j.addr.2021.02.001

Vancouver

Vinarov Z, Abrahamsson B, Artursson P, Batchelor H, Berben P, Bernkop-Schnurch A et al. Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network. Advanced Drug Delivery Reviews. 2021;171:289-331. https://doi.org/10.1016/j.addr.2021.02.001

Author

Vinarov, Zahari ; Abrahamsson, Bertil ; Artursson, Per ; Batchelor, Hannah ; Berben, Philippe ; Bernkop-Schnurch, Andreas ; Butler, James ; Ceulemans, Jens ; Davies, Nigel ; Dupont, Didier ; Flaten, Goril Eide ; Fotaki, Nikoletta ; Griffin, Brendan T. ; Jannin, Vincent ; Keemink, Janneke ; Kesisoglou, Filippos ; Koziolek, Mirko ; Kuentz, Martin ; Mackie, Alan ; Melendez-Martinez, Antonio J. ; McAllister, Mark ; Mullertz, Anette ; O'Driscoll, Caitriona M. ; Parrott, Neil ; Paszkowska, Jadwiga ; Pavek, Petr ; Porter, Christopher J. H. ; Reppas, Christos ; Stillhart, Cordula ; Sugano, Kiyohiko ; Toader, Elena ; Valentova, Katerina ; Vertzoni, Maria ; De Wildt, Saskia N. ; Wilson, Clive G. ; Augustijns, Patrick. / Current challenges and future perspectives in oral absorption research : An opinion of the UNGAP network. In: Advanced Drug Delivery Reviews. 2021 ; Vol. 171. pp. 289-331.

Bibtex

@article{af0342a032744bddae3b63e452f4fb72,
title = "Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network",
abstract = "Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research.(c) 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).",
keywords = "Specific patient populations, Regional differences, Advanced formulations, Amorphous solid dispersions, Lipid-based formulations, Food-drug interactions, Microbiome, In vitro tools, PBPK modeling, IN-VITRO MODELS, BIOPHARMACEUTICS TOOLS PROJECT, LIPID-BASED FORMULATIONS, DRUG-DELIVERY SYSTEMS, DOSAGE FORMS, BIORELEVANT DISSOLUTION, PHARMACOKINETIC PBPK, VIVO PERFORMANCE, FED STATE, INTESTINAL PERMEABILITY",
author = "Zahari Vinarov and Bertil Abrahamsson and Per Artursson and Hannah Batchelor and Philippe Berben and Andreas Bernkop-Schnurch and James Butler and Jens Ceulemans and Nigel Davies and Didier Dupont and Flaten, {Goril Eide} and Nikoletta Fotaki and Griffin, {Brendan T.} and Vincent Jannin and Janneke Keemink and Filippos Kesisoglou and Mirko Koziolek and Martin Kuentz and Alan Mackie and Melendez-Martinez, {Antonio J.} and Mark McAllister and Anette Mullertz and O'Driscoll, {Caitriona M.} and Neil Parrott and Jadwiga Paszkowska and Petr Pavek and Porter, {Christopher J. H.} and Christos Reppas and Cordula Stillhart and Kiyohiko Sugano and Elena Toader and Katerina Valentova and Maria Vertzoni and {De Wildt}, {Saskia N.} and Wilson, {Clive G.} and Patrick Augustijns",
year = "2021",
doi = "10.1016/j.addr.2021.02.001",
language = "English",
volume = "171",
pages = "289--331",
journal = "Advanced Drug Delivery Reviews",
issn = "0169-409X",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Current challenges and future perspectives in oral absorption research

T2 - An opinion of the UNGAP network

AU - Vinarov, Zahari

AU - Abrahamsson, Bertil

AU - Artursson, Per

AU - Batchelor, Hannah

AU - Berben, Philippe

AU - Bernkop-Schnurch, Andreas

AU - Butler, James

AU - Ceulemans, Jens

AU - Davies, Nigel

AU - Dupont, Didier

AU - Flaten, Goril Eide

AU - Fotaki, Nikoletta

AU - Griffin, Brendan T.

AU - Jannin, Vincent

AU - Keemink, Janneke

AU - Kesisoglou, Filippos

AU - Koziolek, Mirko

AU - Kuentz, Martin

AU - Mackie, Alan

AU - Melendez-Martinez, Antonio J.

AU - McAllister, Mark

AU - Mullertz, Anette

AU - O'Driscoll, Caitriona M.

AU - Parrott, Neil

AU - Paszkowska, Jadwiga

AU - Pavek, Petr

AU - Porter, Christopher J. H.

AU - Reppas, Christos

AU - Stillhart, Cordula

AU - Sugano, Kiyohiko

AU - Toader, Elena

AU - Valentova, Katerina

AU - Vertzoni, Maria

AU - De Wildt, Saskia N.

AU - Wilson, Clive G.

AU - Augustijns, Patrick

PY - 2021

Y1 - 2021

N2 - Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research.(c) 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).

AB - Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research.(c) 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).

KW - Specific patient populations

KW - Regional differences

KW - Advanced formulations

KW - Amorphous solid dispersions

KW - Lipid-based formulations

KW - Food-drug interactions

KW - Microbiome

KW - In vitro tools

KW - PBPK modeling

KW - IN-VITRO MODELS

KW - BIOPHARMACEUTICS TOOLS PROJECT

KW - LIPID-BASED FORMULATIONS

KW - DRUG-DELIVERY SYSTEMS

KW - DOSAGE FORMS

KW - BIORELEVANT DISSOLUTION

KW - PHARMACOKINETIC PBPK

KW - VIVO PERFORMANCE

KW - FED STATE

KW - INTESTINAL PERMEABILITY

U2 - 10.1016/j.addr.2021.02.001

DO - 10.1016/j.addr.2021.02.001

M3 - Review

C2 - 33610694

VL - 171

SP - 289

EP - 331

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

SN - 0169-409X

ER -

ID: 272419998