Crystallization of glycine with ultrasound

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Crystallization of glycine with ultrasound. / Louhi-Kultanen, Marjatta; Karjalainen, Milja; Rantanen, Jukka; Huhtanen, Mikko; Kallas, Juha.

In: International Journal of Pharmaceutics, Vol. 320, No. 1-2, 31.08.2006, p. 23-9.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Louhi-Kultanen, M, Karjalainen, M, Rantanen, J, Huhtanen, M & Kallas, J 2006, 'Crystallization of glycine with ultrasound', International Journal of Pharmaceutics, vol. 320, no. 1-2, pp. 23-9. https://doi.org/10.1016/j.ijpharm.2006.03.054

APA

Louhi-Kultanen, M., Karjalainen, M., Rantanen, J., Huhtanen, M., & Kallas, J. (2006). Crystallization of glycine with ultrasound. International Journal of Pharmaceutics, 320(1-2), 23-9. https://doi.org/10.1016/j.ijpharm.2006.03.054

Vancouver

Louhi-Kultanen M, Karjalainen M, Rantanen J, Huhtanen M, Kallas J. Crystallization of glycine with ultrasound. International Journal of Pharmaceutics. 2006 Aug 31;320(1-2):23-9. https://doi.org/10.1016/j.ijpharm.2006.03.054

Author

Louhi-Kultanen, Marjatta ; Karjalainen, Milja ; Rantanen, Jukka ; Huhtanen, Mikko ; Kallas, Juha. / Crystallization of glycine with ultrasound. In: International Journal of Pharmaceutics. 2006 ; Vol. 320, No. 1-2. pp. 23-9.

Bibtex

@article{d9b3ebba0e834f3a8dfba215d7b87061,
title = "Crystallization of glycine with ultrasound",
abstract = "Sonocrystallization has proved to be an efficient tool to influence the external appearance and structure of a crystalline product obtained by various crystallization methods. The present work focuses on high intensity sonocrystallization of glycine by varying amplitude of ultrasound with an ultrasound frequency of 20kHz at two temperature ranges 40-50 and 20-30 degrees C in a jacketed 250-ml cooling crystallizer equipped with a stirrer. The polymorph composition of the obtained crystals was analyzed with a temperature variable X-ray powder diffractometer (XRPD). XRPD results showed that, besides the operating temperature, the glycine polymorphism was affected also by insonation. This was especially the case at the lower temperature range. Furthermore, based on the heat balance within the crystallizer, an increase in required cooling capacity was presented as a function of increasing ultrasound power. This study also showed, the higher the ultrasound amplitude the smaller the crystals obtained.",
keywords = "Chemistry, Pharmaceutical, Crystallization, Crystallography, X-Ray, Glycine, Particle Size, Technology, Pharmaceutical, Temperature, Thermodynamics, Ultrasonics",
author = "Marjatta Louhi-Kultanen and Milja Karjalainen and Jukka Rantanen and Mikko Huhtanen and Juha Kallas",
year = "2006",
month = "8",
day = "31",
doi = "10.1016/j.ijpharm.2006.03.054",
language = "English",
volume = "320",
pages = "23--9",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Crystallization of glycine with ultrasound

AU - Louhi-Kultanen, Marjatta

AU - Karjalainen, Milja

AU - Rantanen, Jukka

AU - Huhtanen, Mikko

AU - Kallas, Juha

PY - 2006/8/31

Y1 - 2006/8/31

N2 - Sonocrystallization has proved to be an efficient tool to influence the external appearance and structure of a crystalline product obtained by various crystallization methods. The present work focuses on high intensity sonocrystallization of glycine by varying amplitude of ultrasound with an ultrasound frequency of 20kHz at two temperature ranges 40-50 and 20-30 degrees C in a jacketed 250-ml cooling crystallizer equipped with a stirrer. The polymorph composition of the obtained crystals was analyzed with a temperature variable X-ray powder diffractometer (XRPD). XRPD results showed that, besides the operating temperature, the glycine polymorphism was affected also by insonation. This was especially the case at the lower temperature range. Furthermore, based on the heat balance within the crystallizer, an increase in required cooling capacity was presented as a function of increasing ultrasound power. This study also showed, the higher the ultrasound amplitude the smaller the crystals obtained.

AB - Sonocrystallization has proved to be an efficient tool to influence the external appearance and structure of a crystalline product obtained by various crystallization methods. The present work focuses on high intensity sonocrystallization of glycine by varying amplitude of ultrasound with an ultrasound frequency of 20kHz at two temperature ranges 40-50 and 20-30 degrees C in a jacketed 250-ml cooling crystallizer equipped with a stirrer. The polymorph composition of the obtained crystals was analyzed with a temperature variable X-ray powder diffractometer (XRPD). XRPD results showed that, besides the operating temperature, the glycine polymorphism was affected also by insonation. This was especially the case at the lower temperature range. Furthermore, based on the heat balance within the crystallizer, an increase in required cooling capacity was presented as a function of increasing ultrasound power. This study also showed, the higher the ultrasound amplitude the smaller the crystals obtained.

KW - Chemistry, Pharmaceutical

KW - Crystallization

KW - Crystallography, X-Ray

KW - Glycine

KW - Particle Size

KW - Technology, Pharmaceutical

KW - Temperature

KW - Thermodynamics

KW - Ultrasonics

U2 - 10.1016/j.ijpharm.2006.03.054

DO - 10.1016/j.ijpharm.2006.03.054

M3 - Journal article

C2 - 16759826

VL - 320

SP - 23

EP - 29

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 140618815