Critical solvent properties affecting the particle formation process and characteristics of celecoxib-loaded PLGA microparticles via spray-drying

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Critical solvent properties affecting the particle formation process and characteristics of celecoxib-loaded PLGA microparticles via spray-drying. / Wan, Feng; Bohr, Adam; Maltesen, Morten Jonas; Bjerregaard, Simon; Foged, Camilla; Rantanen, Jukka; Yang, Mingshi.

In: Pharmaceutical Research, Vol. 30, No. 4, 04.2013, p. 1065-1076.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Wan, F, Bohr, A, Maltesen, MJ, Bjerregaard, S, Foged, C, Rantanen, J & Yang, M 2013, 'Critical solvent properties affecting the particle formation process and characteristics of celecoxib-loaded PLGA microparticles via spray-drying', Pharmaceutical Research, vol. 30, no. 4, pp. 1065-1076. https://doi.org/10.1007/s11095-012-0943-x

APA

Wan, F., Bohr, A., Maltesen, M. J., Bjerregaard, S., Foged, C., Rantanen, J., & Yang, M. (2013). Critical solvent properties affecting the particle formation process and characteristics of celecoxib-loaded PLGA microparticles via spray-drying. Pharmaceutical Research, 30(4), 1065-1076. https://doi.org/10.1007/s11095-012-0943-x

Vancouver

Wan F, Bohr A, Maltesen MJ, Bjerregaard S, Foged C, Rantanen J et al. Critical solvent properties affecting the particle formation process and characteristics of celecoxib-loaded PLGA microparticles via spray-drying. Pharmaceutical Research. 2013 Apr;30(4):1065-1076. https://doi.org/10.1007/s11095-012-0943-x

Author

Wan, Feng ; Bohr, Adam ; Maltesen, Morten Jonas ; Bjerregaard, Simon ; Foged, Camilla ; Rantanen, Jukka ; Yang, Mingshi. / Critical solvent properties affecting the particle formation process and characteristics of celecoxib-loaded PLGA microparticles via spray-drying. In: Pharmaceutical Research. 2013 ; Vol. 30, No. 4. pp. 1065-1076.

Bibtex

@article{df9ec47b4cce41e2877601180535c904,
title = "Critical solvent properties affecting the particle formation process and characteristics of celecoxib-loaded PLGA microparticles via spray-drying",
abstract = "PURPOSE: It is imperative to understand the particle formation mechanisms when designing advanced nano/microparticulate drug delivery systems. We investigated how the solvent power and volatility influence the texture and surface chemistry of celecoxib-loaded poly (lactic-co-glycolic acid) (PLGA) microparticles prepared by spray-drying. METHODS: Binary mixtures of acetone and methanol at different molar ratios were applied to dissolve celecoxib and PLGA prior to spray-drying. The resulting microparticles were characterized with respect to morphology, texture, surface chemistry, solid state properties and drug release profile. The evaporation profiles of the feed solutions were investigated using thermogravimetric analysis (TGA). RESULTS: Spherical PLGA microparticles were obtained, irrespectively of the solvent composition. The particle size and surface chemistry were highly dependent on the solvent power of the feed solution. An obvious burst release was observed for the microparticles prepared by the feed solutions with the highest amount of poor solvent for PLGA. TGA analysis revealed distinct drying kinetics for the binary mixtures. CONCLUSIONS: The particle formation process is mainly governed by the PLGA precipitation rate, which is solvent-dependent, and the migration rate of celecoxib molecules during drying. The texture and surface chemistry of the spray-dried PLGA microparticles can therefore be tailored by adjusting the solvent composition.",
author = "Feng Wan and Adam Bohr and Maltesen, {Morten Jonas} and Simon Bjerregaard and Camilla Foged and Jukka Rantanen and Mingshi Yang",
year = "2013",
month = "4",
doi = "10.1007/s11095-012-0943-x",
language = "English",
volume = "30",
pages = "1065--1076",
journal = "Pharmaceutical Research",
issn = "0724-8741",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Critical solvent properties affecting the particle formation process and characteristics of celecoxib-loaded PLGA microparticles via spray-drying

AU - Wan, Feng

AU - Bohr, Adam

AU - Maltesen, Morten Jonas

AU - Bjerregaard, Simon

AU - Foged, Camilla

AU - Rantanen, Jukka

AU - Yang, Mingshi

PY - 2013/4

Y1 - 2013/4

N2 - PURPOSE: It is imperative to understand the particle formation mechanisms when designing advanced nano/microparticulate drug delivery systems. We investigated how the solvent power and volatility influence the texture and surface chemistry of celecoxib-loaded poly (lactic-co-glycolic acid) (PLGA) microparticles prepared by spray-drying. METHODS: Binary mixtures of acetone and methanol at different molar ratios were applied to dissolve celecoxib and PLGA prior to spray-drying. The resulting microparticles were characterized with respect to morphology, texture, surface chemistry, solid state properties and drug release profile. The evaporation profiles of the feed solutions were investigated using thermogravimetric analysis (TGA). RESULTS: Spherical PLGA microparticles were obtained, irrespectively of the solvent composition. The particle size and surface chemistry were highly dependent on the solvent power of the feed solution. An obvious burst release was observed for the microparticles prepared by the feed solutions with the highest amount of poor solvent for PLGA. TGA analysis revealed distinct drying kinetics for the binary mixtures. CONCLUSIONS: The particle formation process is mainly governed by the PLGA precipitation rate, which is solvent-dependent, and the migration rate of celecoxib molecules during drying. The texture and surface chemistry of the spray-dried PLGA microparticles can therefore be tailored by adjusting the solvent composition.

AB - PURPOSE: It is imperative to understand the particle formation mechanisms when designing advanced nano/microparticulate drug delivery systems. We investigated how the solvent power and volatility influence the texture and surface chemistry of celecoxib-loaded poly (lactic-co-glycolic acid) (PLGA) microparticles prepared by spray-drying. METHODS: Binary mixtures of acetone and methanol at different molar ratios were applied to dissolve celecoxib and PLGA prior to spray-drying. The resulting microparticles were characterized with respect to morphology, texture, surface chemistry, solid state properties and drug release profile. The evaporation profiles of the feed solutions were investigated using thermogravimetric analysis (TGA). RESULTS: Spherical PLGA microparticles were obtained, irrespectively of the solvent composition. The particle size and surface chemistry were highly dependent on the solvent power of the feed solution. An obvious burst release was observed for the microparticles prepared by the feed solutions with the highest amount of poor solvent for PLGA. TGA analysis revealed distinct drying kinetics for the binary mixtures. CONCLUSIONS: The particle formation process is mainly governed by the PLGA precipitation rate, which is solvent-dependent, and the migration rate of celecoxib molecules during drying. The texture and surface chemistry of the spray-dried PLGA microparticles can therefore be tailored by adjusting the solvent composition.

U2 - 10.1007/s11095-012-0943-x

DO - 10.1007/s11095-012-0943-x

M3 - Journal article

C2 - 23263784

VL - 30

SP - 1065

EP - 1076

JO - Pharmaceutical Research

JF - Pharmaceutical Research

SN - 0724-8741

IS - 4

ER -

ID: 44010265