Controlling desolvation through polymer-assisted grinding

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Controlling desolvation through polymer-assisted grinding. / Terban, Maxwell W.; Madhau, Leillah; Cruz-Cabeza, Aurora J.; Okeyo, Peter O.; Etter, Martin; Schulz, Armin; Rantanen, Jukka; Dinnebier, Robert E.; Billinge, Simon J. L.; Moneghini, Mariarosa; Hasa, Dritan.

In: CrystEngComm, Vol. 24, No. 12, 2022, p. 2305-2313.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Terban, MW, Madhau, L, Cruz-Cabeza, AJ, Okeyo, PO, Etter, M, Schulz, A, Rantanen, J, Dinnebier, RE, Billinge, SJL, Moneghini, M & Hasa, D 2022, 'Controlling desolvation through polymer-assisted grinding', CrystEngComm, vol. 24, no. 12, pp. 2305-2313. https://doi.org/10.1039/d2ce00162d

APA

Terban, M. W., Madhau, L., Cruz-Cabeza, A. J., Okeyo, P. O., Etter, M., Schulz, A., Rantanen, J., Dinnebier, R. E., Billinge, S. J. L., Moneghini, M., & Hasa, D. (2022). Controlling desolvation through polymer-assisted grinding. CrystEngComm, 24(12), 2305-2313. https://doi.org/10.1039/d2ce00162d

Vancouver

Terban MW, Madhau L, Cruz-Cabeza AJ, Okeyo PO, Etter M, Schulz A et al. Controlling desolvation through polymer-assisted grinding. CrystEngComm. 2022;24(12):2305-2313. https://doi.org/10.1039/d2ce00162d

Author

Terban, Maxwell W. ; Madhau, Leillah ; Cruz-Cabeza, Aurora J. ; Okeyo, Peter O. ; Etter, Martin ; Schulz, Armin ; Rantanen, Jukka ; Dinnebier, Robert E. ; Billinge, Simon J. L. ; Moneghini, Mariarosa ; Hasa, Dritan. / Controlling desolvation through polymer-assisted grinding. In: CrystEngComm. 2022 ; Vol. 24, No. 12. pp. 2305-2313.

Bibtex

@article{75260defaf7b46838823d6a8561dc95e,
title = "Controlling desolvation through polymer-assisted grinding",
abstract = "We demonstrate the ability to controllably desolvate a crystal-solvate system in a step-wise fashion through polymer-assisted grinding by varying the type and proportion of polymer agent used. A plausible mechanistic explanation is proposed based on a combination of experimental evidence and computational analysis. Specifically, Raman spectroscopy, total scattering pair distribution function analysis and computed reaction energies suggest that the desolvation process is associated with preferred interactions between the solvent molecules and specific polymers. This approach could potentially be extended to any type of material, including heat-sensitive materials, where classical desolvation by thermal processes is not possible, and provides an additional route for formulation processing.",
keywords = "MECHANOCHEMISTRY, DEHYDRATION, POLYMORPH, WATER, REFINEMENT, SORPTION",
author = "Terban, {Maxwell W.} and Leillah Madhau and Cruz-Cabeza, {Aurora J.} and Okeyo, {Peter O.} and Martin Etter and Armin Schulz and Jukka Rantanen and Dinnebier, {Robert E.} and Billinge, {Simon J. L.} and Mariarosa Moneghini and Dritan Hasa",
year = "2022",
doi = "10.1039/d2ce00162d",
language = "English",
volume = "24",
pages = "2305--2313",
journal = "CrystEngComm",
issn = "1466-8033",
publisher = "Royal Society of Chemistry",
number = "12",

}

RIS

TY - JOUR

T1 - Controlling desolvation through polymer-assisted grinding

AU - Terban, Maxwell W.

AU - Madhau, Leillah

AU - Cruz-Cabeza, Aurora J.

AU - Okeyo, Peter O.

AU - Etter, Martin

AU - Schulz, Armin

AU - Rantanen, Jukka

AU - Dinnebier, Robert E.

AU - Billinge, Simon J. L.

AU - Moneghini, Mariarosa

AU - Hasa, Dritan

PY - 2022

Y1 - 2022

N2 - We demonstrate the ability to controllably desolvate a crystal-solvate system in a step-wise fashion through polymer-assisted grinding by varying the type and proportion of polymer agent used. A plausible mechanistic explanation is proposed based on a combination of experimental evidence and computational analysis. Specifically, Raman spectroscopy, total scattering pair distribution function analysis and computed reaction energies suggest that the desolvation process is associated with preferred interactions between the solvent molecules and specific polymers. This approach could potentially be extended to any type of material, including heat-sensitive materials, where classical desolvation by thermal processes is not possible, and provides an additional route for formulation processing.

AB - We demonstrate the ability to controllably desolvate a crystal-solvate system in a step-wise fashion through polymer-assisted grinding by varying the type and proportion of polymer agent used. A plausible mechanistic explanation is proposed based on a combination of experimental evidence and computational analysis. Specifically, Raman spectroscopy, total scattering pair distribution function analysis and computed reaction energies suggest that the desolvation process is associated with preferred interactions between the solvent molecules and specific polymers. This approach could potentially be extended to any type of material, including heat-sensitive materials, where classical desolvation by thermal processes is not possible, and provides an additional route for formulation processing.

KW - MECHANOCHEMISTRY

KW - DEHYDRATION

KW - POLYMORPH

KW - WATER

KW - REFINEMENT

KW - SORPTION

U2 - 10.1039/d2ce00162d

DO - 10.1039/d2ce00162d

M3 - Journal article

VL - 24

SP - 2305

EP - 2313

JO - CrystEngComm

JF - CrystEngComm

SN - 1466-8033

IS - 12

ER -

ID: 302450702