Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing. / Liu, Xiaoli; Nielsen, Line Hagner; Klodzinska, Sylvia Natalie; Nielsen, Hanne Mørck; Qu, Haiyan; Christensen, Lars Porskjær; Rantanen, Jukka; Yang, Mingshi.

In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Vol. 123, 02.2018, p. 42-49.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Liu, X, Nielsen, LH, Klodzinska, SN, Nielsen, HM, Qu, H, Christensen, LP, Rantanen, J & Yang, M 2018, 'Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing', European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, vol. 123, pp. 42-49. https://doi.org/10.1016/j.ejpb.2017.11.004

APA

Liu, X., Nielsen, L. H., Klodzinska, S. N., Nielsen, H. M., Qu, H., Christensen, L. P., ... Yang, M. (2018). Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 123, 42-49. https://doi.org/10.1016/j.ejpb.2017.11.004

Vancouver

Liu X, Nielsen LH, Klodzinska SN, Nielsen HM, Qu H, Christensen LP et al. Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2018 Feb;123:42-49. https://doi.org/10.1016/j.ejpb.2017.11.004

Author

Liu, Xiaoli ; Nielsen, Line Hagner ; Klodzinska, Sylvia Natalie ; Nielsen, Hanne Mørck ; Qu, Haiyan ; Christensen, Lars Porskjær ; Rantanen, Jukka ; Yang, Mingshi. / Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing. In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2018 ; Vol. 123. pp. 42-49.

Bibtex

@article{3afc3d6e337540959b06b666d608cb12,
title = "Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing",
abstract = "Wound dressings should ideally be able to maintain high humidity, remove excess wound exudate, permit thermal insulation, provide certain mechanical strength, and in some cases deliver antibiotics to prevent infections. Until now, none of the existing wound dressing products can meet all these requirements. To design a wound dressing with as many of the aforementioned features as possible, in this study, we attempted to prepare ciprofloxacin (CIP), an antibiotic, loaded electrospun hydrophobic poly (lactic-co-glycolic acid) (PLGA) fibrous mats modified with hydrophilic sodium alginate (ALG) microparticles. The results showed that ALG could improve the wettability, water absorption capacity, and enhance the release rate of ciprofloxacin from the PLGA fibrous mats. In addition, the addition of ALG reduced the stiffness of PLGA fibrous mats for better protection of the injured area as indicated by the Young's Modulus. Moreover, the burst release of CIP resulted from the addition of ALG seemed to provide an improved antibacterial effect to the PLGA mats. This study demonstrated the potential of combining hydrophilic and hydrophobic polymers to design the desired wound dressings via the electrospinning process.",
keywords = "Journal Article",
author = "Xiaoli Liu and Nielsen, {Line Hagner} and Klodzinska, {Sylvia Natalie} and Nielsen, {Hanne M{\o}rck} and Haiyan Qu and Christensen, {Lars Porskj{\ae}r} and Jukka Rantanen and Mingshi Yang",
note = "Copyright {\circledC} 2017. Published by Elsevier B.V.",
year = "2018",
month = "2",
doi = "10.1016/j.ejpb.2017.11.004",
language = "English",
volume = "123",
pages = "42--49",
journal = "European Journal of Pharmaceutics and Biopharmaceutics",
issn = "0939-6411",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing

AU - Liu, Xiaoli

AU - Nielsen, Line Hagner

AU - Klodzinska, Sylvia Natalie

AU - Nielsen, Hanne Mørck

AU - Qu, Haiyan

AU - Christensen, Lars Porskjær

AU - Rantanen, Jukka

AU - Yang, Mingshi

N1 - Copyright © 2017. Published by Elsevier B.V.

PY - 2018/2

Y1 - 2018/2

N2 - Wound dressings should ideally be able to maintain high humidity, remove excess wound exudate, permit thermal insulation, provide certain mechanical strength, and in some cases deliver antibiotics to prevent infections. Until now, none of the existing wound dressing products can meet all these requirements. To design a wound dressing with as many of the aforementioned features as possible, in this study, we attempted to prepare ciprofloxacin (CIP), an antibiotic, loaded electrospun hydrophobic poly (lactic-co-glycolic acid) (PLGA) fibrous mats modified with hydrophilic sodium alginate (ALG) microparticles. The results showed that ALG could improve the wettability, water absorption capacity, and enhance the release rate of ciprofloxacin from the PLGA fibrous mats. In addition, the addition of ALG reduced the stiffness of PLGA fibrous mats for better protection of the injured area as indicated by the Young's Modulus. Moreover, the burst release of CIP resulted from the addition of ALG seemed to provide an improved antibacterial effect to the PLGA mats. This study demonstrated the potential of combining hydrophilic and hydrophobic polymers to design the desired wound dressings via the electrospinning process.

AB - Wound dressings should ideally be able to maintain high humidity, remove excess wound exudate, permit thermal insulation, provide certain mechanical strength, and in some cases deliver antibiotics to prevent infections. Until now, none of the existing wound dressing products can meet all these requirements. To design a wound dressing with as many of the aforementioned features as possible, in this study, we attempted to prepare ciprofloxacin (CIP), an antibiotic, loaded electrospun hydrophobic poly (lactic-co-glycolic acid) (PLGA) fibrous mats modified with hydrophilic sodium alginate (ALG) microparticles. The results showed that ALG could improve the wettability, water absorption capacity, and enhance the release rate of ciprofloxacin from the PLGA fibrous mats. In addition, the addition of ALG reduced the stiffness of PLGA fibrous mats for better protection of the injured area as indicated by the Young's Modulus. Moreover, the burst release of CIP resulted from the addition of ALG seemed to provide an improved antibacterial effect to the PLGA mats. This study demonstrated the potential of combining hydrophilic and hydrophobic polymers to design the desired wound dressings via the electrospinning process.

KW - Journal Article

U2 - 10.1016/j.ejpb.2017.11.004

DO - 10.1016/j.ejpb.2017.11.004

M3 - Journal article

VL - 123

SP - 42

EP - 49

JO - European Journal of Pharmaceutics and Biopharmaceutics

T2 - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

SN - 0939-6411

ER -

ID: 185717720