Characterization of the bulk properties of pharmaceutical solids using nonlinear optics-a review
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Characterization of the bulk properties of pharmaceutical solids using nonlinear optics-a review. / Lee, Chris J; Strachan, Clare J; Manson, Peter J; Rades, Thomas.
In: Journal of Pharmacy and Pharmacology, Vol. 59, No. 2, 2007, p. 241-50.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Characterization of the bulk properties of pharmaceutical solids using nonlinear optics-a review
AU - Lee, Chris J
AU - Strachan, Clare J
AU - Manson, Peter J
AU - Rades, Thomas
PY - 2007
Y1 - 2007
N2 - With the development of stable, compact and reliable pulsed laser sources the field of characterizing materials through their nonlinear optical response has bloomed. Second harmonic generation by non-centrosymmetric crystal structures has provided a new spectroscopic tool of potentially great utility in the pharmaceutical field. The nonlinear optical response of various materials provides a very sensitive technique for the characterization of pharmaceutically interesting bulk compounds and dispersions, and determining their concentrations. This work has potential application for in-line monitoring and quality control of pharmaceutical manufacturing. In this article we have presented an extensive review of the spectroscopic techniques that make use of the nonlinear optical response of solid media. Also, we have presented the results of our own work in this field.
AB - With the development of stable, compact and reliable pulsed laser sources the field of characterizing materials through their nonlinear optical response has bloomed. Second harmonic generation by non-centrosymmetric crystal structures has provided a new spectroscopic tool of potentially great utility in the pharmaceutical field. The nonlinear optical response of various materials provides a very sensitive technique for the characterization of pharmaceutically interesting bulk compounds and dispersions, and determining their concentrations. This work has potential application for in-line monitoring and quality control of pharmaceutical manufacturing. In this article we have presented an extensive review of the spectroscopic techniques that make use of the nonlinear optical response of solid media. Also, we have presented the results of our own work in this field.
U2 - 10.1211/jpp.59.2.0010
DO - 10.1211/jpp.59.2.0010
M3 - Journal article
C2 - 17270077
VL - 59
SP - 241
EP - 250
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
SN - 0022-3573
IS - 2
ER -
ID: 40354517