Characterisation of colloidal drug delivery systems from the naked eye to Cryo-FESEM

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Characterisation of colloidal drug delivery systems from the naked eye to Cryo-FESEM. / Krauel, Karen; Girvan, Liz; Hook, Sarah; Rades, Thomas.

In: Micron, Vol. 38, No. 8, 2007, p. 796-803.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Krauel, K, Girvan, L, Hook, S & Rades, T 2007, 'Characterisation of colloidal drug delivery systems from the naked eye to Cryo-FESEM', Micron, vol. 38, no. 8, pp. 796-803. https://doi.org/10.1016/j.micron.2007.06.008

APA

Krauel, K., Girvan, L., Hook, S., & Rades, T. (2007). Characterisation of colloidal drug delivery systems from the naked eye to Cryo-FESEM. Micron, 38(8), 796-803. https://doi.org/10.1016/j.micron.2007.06.008

Vancouver

Krauel K, Girvan L, Hook S, Rades T. Characterisation of colloidal drug delivery systems from the naked eye to Cryo-FESEM. Micron. 2007;38(8):796-803. https://doi.org/10.1016/j.micron.2007.06.008

Author

Krauel, Karen ; Girvan, Liz ; Hook, Sarah ; Rades, Thomas. / Characterisation of colloidal drug delivery systems from the naked eye to Cryo-FESEM. In: Micron. 2007 ; Vol. 38, No. 8. pp. 796-803.

Bibtex

@article{eaf69cf99e2d4587926849beeda1796a,
title = "Characterisation of colloidal drug delivery systems from the naked eye to Cryo-FESEM",
abstract = "Poly(ethylcyanoacrylate) nanoparticles prepared by interfacial polymerisation on the basis of microemulsions were prepared in this study and both colloidal systems, nanoparticles and microemulsions, were analysed by visual observation and several microscopic techniques. Phase boundaries for the microemulsions of the two pseudoternary systems ethyloleate, polyoxyethylene 20 sorbitan mono-oleate/sorbitan monolaurate and water with and without butanol as a cosurfactant were determined by visual observation of the samples. Microemulsions containing liquid crystals were determined by polarisation light microscopy. Using freeze-fracture transmission electron microscopy and Cryo-field emission scanning electron microscopy the type of microemulsion (w/o droplet, bicontinuous, solution) was characterised. Nanoparticles prepared from the different types of microemulsion were additionally observed by conventional scanning electron microscopy. The size of the nanoparticles obtained from electron microscopy was in good agreement with particle sizing techniques (photon correlation spectroscopy) from earlier studies and no morphological differences could be observed in particles prepared from the different types of microemulsions. Cryo-field emission scanning electron microscopy proved to be a most valuable technique in the visualisation of the colloidal systems as samples could be observed close to their natural state.",
keywords = "Cryoelectron Microscopy, Drug Delivery Systems, Emulsions, Freeze Fracturing, Microscopy, Electron, Scanning, Nanoparticles",
author = "Karen Krauel and Liz Girvan and Sarah Hook and Thomas Rades",
year = "2007",
doi = "10.1016/j.micron.2007.06.008",
language = "English",
volume = "38",
pages = "796--803",
journal = "Micron",
issn = "0968-4328",
publisher = "Pergamon Press",
number = "8",

}

RIS

TY - JOUR

T1 - Characterisation of colloidal drug delivery systems from the naked eye to Cryo-FESEM

AU - Krauel, Karen

AU - Girvan, Liz

AU - Hook, Sarah

AU - Rades, Thomas

PY - 2007

Y1 - 2007

N2 - Poly(ethylcyanoacrylate) nanoparticles prepared by interfacial polymerisation on the basis of microemulsions were prepared in this study and both colloidal systems, nanoparticles and microemulsions, were analysed by visual observation and several microscopic techniques. Phase boundaries for the microemulsions of the two pseudoternary systems ethyloleate, polyoxyethylene 20 sorbitan mono-oleate/sorbitan monolaurate and water with and without butanol as a cosurfactant were determined by visual observation of the samples. Microemulsions containing liquid crystals were determined by polarisation light microscopy. Using freeze-fracture transmission electron microscopy and Cryo-field emission scanning electron microscopy the type of microemulsion (w/o droplet, bicontinuous, solution) was characterised. Nanoparticles prepared from the different types of microemulsion were additionally observed by conventional scanning electron microscopy. The size of the nanoparticles obtained from electron microscopy was in good agreement with particle sizing techniques (photon correlation spectroscopy) from earlier studies and no morphological differences could be observed in particles prepared from the different types of microemulsions. Cryo-field emission scanning electron microscopy proved to be a most valuable technique in the visualisation of the colloidal systems as samples could be observed close to their natural state.

AB - Poly(ethylcyanoacrylate) nanoparticles prepared by interfacial polymerisation on the basis of microemulsions were prepared in this study and both colloidal systems, nanoparticles and microemulsions, were analysed by visual observation and several microscopic techniques. Phase boundaries for the microemulsions of the two pseudoternary systems ethyloleate, polyoxyethylene 20 sorbitan mono-oleate/sorbitan monolaurate and water with and without butanol as a cosurfactant were determined by visual observation of the samples. Microemulsions containing liquid crystals were determined by polarisation light microscopy. Using freeze-fracture transmission electron microscopy and Cryo-field emission scanning electron microscopy the type of microemulsion (w/o droplet, bicontinuous, solution) was characterised. Nanoparticles prepared from the different types of microemulsion were additionally observed by conventional scanning electron microscopy. The size of the nanoparticles obtained from electron microscopy was in good agreement with particle sizing techniques (photon correlation spectroscopy) from earlier studies and no morphological differences could be observed in particles prepared from the different types of microemulsions. Cryo-field emission scanning electron microscopy proved to be a most valuable technique in the visualisation of the colloidal systems as samples could be observed close to their natural state.

KW - Cryoelectron Microscopy

KW - Drug Delivery Systems

KW - Emulsions

KW - Freeze Fracturing

KW - Microscopy, Electron, Scanning

KW - Nanoparticles

U2 - 10.1016/j.micron.2007.06.008

DO - 10.1016/j.micron.2007.06.008

M3 - Journal article

C2 - 17698364

VL - 38

SP - 796

EP - 803

JO - Micron

JF - Micron

SN - 0968-4328

IS - 8

ER -

ID: 40354258