Research areas

  1. Published

    Introduction to pharmaceutical chemical analysis

    Hansen, S. H., Pedersen-Bjergaard, Stig & Rasmussen, K. E., 2012, Chichester: Wiley. 477 p.

    Research output: Book/ReportBookpeer-review

  2. Published

    Investigation of a liposomal oxaliplatin drug formulation by capillary electrophoresis hyphenated to inductively coupled plasma mass spectrometry (CE-ICP-MS)

    Nguyen, T. T. N. T., Østergaard, Jesper, Stürup, Stefan & Gammelgaard, Bente, 2012, In: Analytical and Bioanalytical Chemistry. 402, p. 2131-2139

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Investigation of solid phase composition on tablet surfaces by grazing incidence X-ray diffraction

    Koradia, V. S., Tenho, M., Diego, H. L. D., Ringkjøbing-Elma, M., Møller-Sonnergaard, Jørn, Salonen, J., Lehto, V. & Rantanen, Jukka, 2012, In: Pharmaceutical Research. 29, 1, p. 134-144

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Kinetic and structural analyses of Jumonji C histone demethylases for identification of new inhibitors

    Kristensen, L. H., 2012, København: Faculty of Health and Medical Sciences, University of Copenhagen. 168 p.

    Research output: Book/ReportPh.D. thesis

  5. Published

    License to kill: formulation requirements for optimal priming of CD8+ CTL responses with particulate vaccine delivery systems

    Foged, Camilla, Hansen, J. & Agger, E. M., 2012, In: European Journal of Pharmaceutical Sciences. 45, 4, p. 482-491

    Research output: Contribution to journalJournal articlepeer-review

  6. Published

    Liquid-phase microextraction and desorption electrospray ionization mass spectrometry for identification and quantification of basic drugs in human urine

    Thunig, J., Flø, L., Pedersen-Bjergaard, Stig, Hansen, S. H. & Janfelt, Christian, 2012, In: Rapid Communications in Massspectrometry. 26, 2, p. 133-140

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    Measurement of drug diffusivities in pharmaceutical solvents using Taylor dispersion analysis

    Ye, F., Jensen, H., Larsen, Susan Weng, Yaghmur, Anan, Larsen, C. S. & Østergaard, Jesper, 2012, In: Journal of Pharmaceutical and Biomedical Analysis. 61, p. 176-183

    Research output: Contribution to journalJournal articlepeer-review

  8. Published

    Mechanistic studies of the effect of bile salts on rhodamine 123 uptake into RBE4 cells

    Yang, L., Fawcett, J. P., Østergaard, Jesper, Zhang, H. & Tucker, I. G., 2012, In: Molecular Pharmaceutics. 9, 1, p. 29-36

    Research output: Contribution to journalJournal articlepeer-review

  9. Published

    Modelling the carbon cycle of Siena province (Tuscany, central Italy)

    Marchi, M., Jørgensen, S. E., Pulselli, F. M., Marchettini, N. & Bastianoni, S., 2012, In: Ecological Modelling. 225, p. 40-60

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    Multidisciplinary management of metastatic renal cell carcinoma in the era of targeted therapies

    Escudier, B., Osanto, S., Ljungberg, B., Porta, C., Wagstaff, J., Mulders, P., Gore, M., Bex, A., Bellmunt, J., Bracarda, S., Franklin, A., Honoré, P. G. H., Ravaud, A., Stein, J. V., Aziz, Z. & Akaza, H., 2012, In: Cancer Treatment Reviews. 38, 2, p. 127-132 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    NMR spectroscopy for metabolic profiling of plant extracts

    Yilmaz, A., 2012, København: Faculty of Health and Medical Sciences, University of Copenhagen. 114 p.

    Research output: Book/ReportPh.D. thesis

  12. Published

    Polymer-mediated anti-solvent crystallization of nitrendipine: Monodispersed spherical crystals and growth mechanism

    Xia, D., Ouyang, M., Wu, J., Jiang, Y., Piao, H., Sun, S., Zheng, L., Rantanen, Jukka, Cui, F. & Yang, Mingshi, 2012, In: Pharmaceutical Research. 29, p. 158-169

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    RS-Predictor models augmented with SMARTCyp reactivities: robust metabolic regioselectivity predictions for nine CYP isozymes

    Zaretzki, J., Rydberg, P., Bergeron, C., Bennett, K. P., Olsen, L. & Breneman, C. M., 2012, In: Journal of Chemical Information and Modeling. 52, 6, p. 1637-1659

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    Real-time UV imaging of piroxicam diffusion and distribution from oil solutions into gels mimicking the subcutaneous matrix

    Ye, F., Larsen, Susan Weng, Yaghmur, Anan, Jensen, H., Larsen, C. S. & Østergaard, Jesper, 2012, In: European Journal of Pharmaceutical Sciences. 46, 1-2, p. 72-78

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    Role of Cu2+ in oligomerization and aggregation of alzheimer's amyloid-β peptides

    Pedersen, J. T., 2012, København: Det Farmaceutiske Fakultetsbibliotek, Det Farmaceutiske Fakultet, Københavns Universitet. 85 p.

    Research output: Book/ReportPh.D. thesis

  16. Published

    Role of excipients on solid-state properties of piroxicam during processing

    Christensen, N. P. A., Cornett, Claus & Rantanen, Jukka, 2012, In: Journal of Pharmaceutical Sciences. 101, 3, p. 1202-1211

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    Self-assembled nanostructures of fully hydrated monoelaidin - Elaidic and monoelaidin - Oleic acid systems

    Yaghmur, Anan, Satori, B. & Rappolt, M., 2012, In: Langmuir. 28, p. 10105-10119

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    Site-specific analysis of gas-phase hydrogen/deuterium exchange of peptides and proteins by electron transfer dessociation

    Rand, Kasper Dyrberg, Pringle, S. D., Morris, M. & Brown, J. M., 2012, In: Analytical Chemistry. 84, 4, p. 1931-1940

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    Structure-activity relationships for negative allosteric mGluR5 modulators

    Kaae, B. H., Harpsøe, Kasper, Kvist, T., Mathiesen, Jesper M., Mølck, C., Gloriam, David E., Jimenez, H. N., Uberti, M. A., Nielsen, S. M., Nielsen, Birgitte, Bräuner, Hans, Sauerberg, P., Clausen, Rasmus Prætorius & Madsen, Ulf, 2012, In: ChemMedChem. 7, 3, p. 440-451

    Research output: Contribution to journalJournal articlepeer-review

  20. Published

    Tool boxes for an integrated ecological and environmental management

    Jørgensen, S. E. & Nielsen, S. N., 2012, In: Ecological Indicators. 21, p. 104-109

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    Using resin to generate a non-invasive intestinal bile-depleted rat model was unsuccessful

    Holm, R., Hesselkilde, J. Z., Jørgensen, E. B. & Mullertz, Anette , 2012, In: European Journal of Pharmaceutical Sciences. 47, p. 347-351

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Volatile organic compounds in landfill ordorant emissions on the island of Mallorca

    González, C. R., Björklund, E., Forteza, R. & Cerdà, V., 2012, In: International Journal of Environmental Analytical Chemistry. 92, 12, p. 1-16, iFirst

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    Evaluation of the antibacterial activity of Chilean plants traditionally used for wound healing therapy against multidrug-resistant Staphylococcus aureus

    Holler, J. G., Søndergaard, K., Slotved, H., Gúzman, A. & Mølgaard, Per, Jan 2012, In: Planta Medica. 78, 2, p. 200-205

    Research output: Contribution to journalLetterpeer-review

  24. Published

    Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains

    Haq, S. R., Chi, C. N., Bach, Anders, Dogan, J., Engström, Å., Hultqvist, G., Karlsson, O. A., Lundström, P., Montemiglio, L. C., Strømgaard, Kristian, Gianni, S. & Jemth, P., Jan 2012, In: Journal of the American Chemical Society. 134, 1, p. 599-605

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent gamma-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction

    Pan, Y., Gerasimov, M. R., Kvist, T., Wellendorph, Petrine, Madsen, K. K., Pera, E., Lee, H., Schousboe, Arne, Chebib, M., Bräuner, Hans, Craft, C. M., Brodie, J. D., Schiffer, W. K., Dewey, S. L., Miller, S. R. & Silverman, R. B., 1 Jan 2012, In: Journal of Medicinal Chemistry. 55, 1, p. 357-366

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2

    Krintel, C., Frydenvang, Karla Andrea, Olsen, L., Kristensen, M. T., de Barrios, O., Naur, P., Francotte, P., Pirotte, B., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 1 Jan 2012, In: Biochemical Journal. 441, 1, p. 173-178

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Ligand-based site of metabolism prediction for cytochrome P450 2D6

    Rydberg, P. & Olsen, L., 12 Jan 2012, In: A C S Medicinal Chemistry Letters. 3, 1, p. 69-73

    Research output: Contribution to journalLetterpeer-review

  28. Published

    3-Alkyl- and 3-amido-isothiazoloquinolin-4-ones as ligands for the benzodiazepine site of GABAA receptors

    Nilsson, J., Nielsen, E. Ø., Liljefors, T., Nielsen, M. P. C. & Sterner, O., Feb 2012, In: Bioorganic Chemistry. 40, p. 125-130

    Research output: Contribution to journalJournal articlepeer-review

  29. Published

    Biased agonism of the calcium-sensing receptor

    Thomsen, A. R. B., Hvidtfeldt, M. & Bräuner, Hans, Feb 2012, In: Cell Calcium. 51, 2, p. 107-116

    Research output: Contribution to journalJournal articlepeer-review

  30. Published

    Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors: Unique role of halogen bonding revealed

    Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. Ø., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, Kasper, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 3 Feb 2012, In: The Journal of Biological Chemistry. 287, 6, p. 4248-4259

    Research output: Contribution to journalJournal articlepeer-review

  31. Published

    Concise synthesis of new bridged-nicotine analogues

    Crestey, F., Hooyberghs, G. & Kristensen, Jesper Langgaard, 4 Feb 2012, In: Tetrahedron. 68, 5, p. 1417-1421

    Research output: Contribution to journalJournal articlepeer-review

  32. Published

    Comment on "Binding free energies of inhibitors to iron porphyrin complex as a model for cytochrome P450"

    Rydberg, P., Apr 2012, In: Biopolymers. 97, 4, p. 250-251

    Research output: Contribution to journalComment/debatepeer-review

  33. Published

    Chemical composition of the essential oil from Microlicia graveolens growing wild in Minas Gerais

    Toudahl, A. B., Filho, S. A. V., Souza, G. H. B., Morais, L. D., dos Santos, O. D. H. & Jäger, A., May 2012, In: Revista Brasileira de Farmacognosia. 22, 3, p. 680-681

    Research output: Contribution to journalLetterpeer-review

  34. Published

    Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor

    Kristensen, L. H., Nielsen, A. L., Helgstrand, C., Lees, M., Cloos, P., Kastrup, Jette Sandholm Jensen, Helin, K., Olsen, L. & Gajhede, Michael, Jun 2012, In: F E B S Journal. 279, 11, p. 1905-1914

    Research output: Contribution to journalJournal articlepeer-review

  35. Published

    Genetic fuzzy system modeling and simulation of vascular behaviour

    Tang, J. & Boonen, H. C. M., 13 Jun 2012. 1 p.

    Research output: Contribution to conferencePosterResearchpeer-review

  36. Published

    Solvent-mediated amorphous-to-crystalline transformation of nitrendipine in amorphous particle suspensions containing polymers

    Xia, D., Wu, J., Cui, F., Qu, H., Rades, Thomas, Rantanen, Jukka & Yang, Mingshi, 15 Aug 2012, In: European Journal of Pharmaceutical Sciences. 46, 5, p. 446-454 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  37. Published

    Quality assessment of Tulbaghia rhizomes

    Jäger, A. & Stafford, G. I., Sep 2012, In: South African Journal of Botany. 82, p. 92-98 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  38. Published

    Strategic funding priorities in the pharmaceutical sciences allied to Quality by Design (QbD) and Process Analytical Technology (PAT)

    Aksu, B., De Beer, T., Folestad, S., Ketolainen, J., Lindén, H., Lopes, J. A., de Matas, M., Oostra, W., Rantanen, Jukka & Weimer, M., 29 Sep 2012, In: European Journal of Pharmaceutical Sciences. 47, 2, p. 402-405 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  39. Published

    Exploring the solid-form landscape of pharmaceutical hydrates: transformation pathways of the sodium naproxen anhydrate-hydrate system

    Raijada, D. K., Bond, A., Larsen, F. H., Cornett, Claus, Qu, H. & Rantanen, Jukka, 2013, In: Pharmaceutical Research. 30, 1, p. 280-289 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  40. Published

    Lactate dehydrogenase assay for assessment of polycation cytotoxicity

    Parhamifar, L., Andersen, H. & Moghimi, S. M., 2013, Nanotechnology for Nucleic Acid Delivery. Vol. 948. p. 13-22 10 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  41. Published

    Pollution Pathways of Pharmaceutical Residues in the Aquatic Environment on the Island of Mallorca, Spain

    Rodríguez-Navas, C., Björklund, E., Bak, S. A., Hansen, M., Krogh, K. A., Maya, F., Forteza, R. & Cerdà, V., 2013, In: Archives of Environmental Contamination and Toxicology. 61, 1, p. 56-66

    Research output: Contribution to journalJournal articlepeer-review

  42. Exploring the solid-form landscape of pharmaceutical hydrates: transformation pathways of the sodium naproxen anhydrate-hydrate system

    Raijada, D. K., Bond, A., Larsen, F. H., Cornett, C., Qu, H. & Rantanen, J., Jan 2013, In: Pharmaceutical Research. 30, 1, p. 280-289 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    Altered anziety/depression-like behaviours in mice deficient in tetrahydrobiopterin

    Nasser, A., Birk Møller, L. & Andreasen T., Jesper, 13 Jan 2013.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  44. Published

    Development and validation of an SPE methodology combined with LC-MS/MS for the determination of four ionophores in aqueous environmental matrices

    Bak, S. A., Hansen, M., Krogh, K. A., Brandt, A., Halling-Sørensen, B. & Björklund, E., 25 Feb 2013, In: International Journal of Environmental Analytical Chemistry. 93, 14, p. 1500-1512

    Research output: Contribution to journalJournal articlepeer-review

  45. Liposomal temocene (m-THPPo) photodynamic treatment induces cell death by mitochondria-independent apoptosis

    Soriano, J., Garcia-Diaz, M., Mora, M., Sagristá, M. L., Nonell, S., Villanueva, A., Stockert, J. C. & Cañete, M., 28 May 2013, In: BBA General Subjects. 1830, 10, p. 4611-4620 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  46. Published

    Prolonged naproxen joint residence time after intra-articular injection of lipophilic solutions comprising a naproxen glycolamide ester prodrug in the rat

    Thing, M., Lu, Y., Agårdh, L., Larsen, C. S., Østergaard, Jesper, He, W., Wu, W., Larsen, F. & Larsen, Susan Weng, 15 Jul 2013, In: International Journal of Pharmaceutics. 451, 1-2, p. 34-40 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  47. Published

    Organ culture of C57BL/6 mouse arteries with LPS as an in vitro model of vascular inflammation

    Outzen, E. M., Mehryar, R., Boonen, H. C. M., Nielsen, A. S. & Sheykhzade, Majid, 28 Aug 2013. 1 p.

    Research output: Contribution to conferencePosterResearch

  48. Published

    Pattern-oriented Agent-based Monte Carlo simulation of Cellular Redox Environment

    Tang, J., Holcombe, M. & Boonen, H. C. M., 28 Aug 2013. 1 p.

    Research output: Contribution to conferencePosterResearch

  49. Published

    The PPARalpha agonist, fenofibrate decreases levels of anorectic N-acylethanolamines in the small intestine of mice

    Diep, T. A., Golbas, G. & Hansen, Harald S., 28 Jun 2014. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  50. Published

    Investigations and design of pyridine-2-carboxylic acid thiazol-2-ylamide analogs as methionine aminopeptidase inhibitors using 3D-QSAR and molecular docking

    Hauser, Alexander Sebastian, 1 Aug 2014, In: Medicinal Chemistry Research. 23, 8, p. 3861 3875 p.

    Research output: Contribution to journalJournal articlepeer-review

  51. Published

    Noter til Organisk Kemi for Biovidenskab: Organisk og bioorganisk kemi 2015

    Nielsen, J., 9 Feb 2015, 25 p.

    Research output: Other contributionEducation

  52. Published

    Kolliphor surfactants affect solubilization and bioavailability of fenofibrate. Studies of in vitro digestion and absorption in rats.

    Berthelsen, R., Holm, R., Jacobsen, Jette, Kristensen, J., Abrahamsson, B. & Mullertz, Anette , 6 Apr 2015, In: Molecular Pharmaceutics. 12, 4, p. 1062-1071 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  53. Published

    Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score

    Laustsen, A. H. & Lohse, B., 15 Sep 2015, In: Toxicon. 104, p. 43-45 3 p.

    Research output: Contribution to journalLetterpeer-review

  54. Published

    Thapsigargin, origin, chemistry, structure-activity relationships and prodrug development.

    Doan, T. Q. N. & Christensen, Søren Brøgger, Oct 2015, In: Current Pharmaceutical Design. 21, 38, p. 5505-5517 13 p.

    Research output: Contribution to journalReviewpeer-review

  55. Published

    Cytochrome P450 Mediated Drug Metabolism

    Olsen, L., Jørgensen, Flemming Steen & Oostenbrink, C., 2016, New Horizons in Predictive Drug Metabolism and Pharmacokinetics. Wilson, A. G. E. (ed.). Cambridge: Royal Society of Chemistry, p. 66-78 13 p. (RSC Drug Discovery, Vol. 49).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  56. Published

    Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation

    Jensen, C. M., Chow, H., Chen, M., Zhai, L., Frydenvang, Karla Andrea, Liu, H., Franzyk, Henrik & Christensen, Søren Brøgger, 2016, In: European Journal of Medicinal Chemistry. 114, p. 118-133 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  57. Published

    The potential of protein-nanomaterial interaction for advanced drug delivery

    Peng, Q. & Mu, Huiling, 23 Jan 2016, In: Journal of Controlled Release. 225, p. 121-132 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  58. Published

    Basic characteristics and kinetics of degradation in aqueous buffer of selected diclofenac prodrugs intended for joint injection

    Mertz, Nina, Larsen, Susan Weng & Larsen, C. S., 6 Apr 2016. 1 p.

    Research output: Contribution to conferencePosterResearchpeer-review

  59. Published

    Lithostratigraphy, geology and geochemisttry of the volcanic rocks of the Vaigat Formation on Disko and Nuussuaq, Paleocene of West Greenland

    Pedersen, Asger Ken, Larsen, L. M. & Pedersen, G. K., 2017, Copenhagen: The Geological Survey of Denmark and Greenland. 244 p. (Geological Survey of Denmark and Greenland (GEUS) Bulletin, Vol. 39).

    Research output: Book/ReportBookpeer-review

  60. Published

    Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs

    Krall, J., Jensen, C. H., Bavo, F., Falk-Petersen, C. B., Haugaard, A. S., Vogensen, S. B., Tian, Y., Nittegaard-Nielsen, M., Sigurdardóttir, S. B., Kehler, J., Kongstad, Kenneth Thermann, Gloriam, David E., Clausen, Rasmus Prætorius, Harpsøe, Kasper, Wellendorph, Petrine & Frølund, Bente, 2017, In: Journal of Medicinal Chemistry. 60, 21, p. 9022-9039 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  61. Published

    Structure/activity Relationship of Thapsigargin Inhibition on the Purified Golgi/secretory Pathway Ca2+/Mn2+-Transport ATPase (SPCA1a)

    Jialin, C., de Raeymaecker, J., Hovgaard, J. B., Smaardijk, S., Vandecaetsbeek, I., Wuytack, F., Møller, J. V., Eggermont, J., de Meyer, M., Christensen, Søren Brøgger & Vangheluwe, P., 2017, In: Journal of Biological Chemistry. 292, 17, p. 6938-6951 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  62. Published

    Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis

    Zimmermann, T., Christensen, Søren Brøgger & Franzyk, Henrik, 15 Jun 2018, In: Molecules. 23, 6, 13 p., 1463.

    Research output: Contribution to journalJournal articlepeer-review

  63. Published

    Phorbol Rearrangements

    Zimmermann, T., Franzyk, Henrik & Christensen, Søren Brøgger, 28 Sep 2018, In: Journal of Natural Products. 81, 9, p. 2134-2137 4 p.

    Research output: Contribution to journalJournal articlepeer-review

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