Research areas

  1. Published

    Phorbol Rearrangements

    Zimmermann, T., Franzyk, Henrik & Christensen, Søren Brøgger, 28 Sep 2018, In: Journal of Natural Products. 81, 9, p. 2134-2137 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  2. Published

    Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis

    Zimmermann, T., Christensen, Søren Brøgger & Franzyk, Henrik, 15 Jun 2018, In: Molecules. 23, 6, 13 p., 1463.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Structure/activity Relationship of Thapsigargin Inhibition on the Purified Golgi/secretory Pathway Ca2+/Mn2+-Transport ATPase (SPCA1a)

    Jialin, C., de Raeymaecker, J., Hovgaard, J. B., Smaardijk, S., Vandecaetsbeek, I., Wuytack, F., Møller, J. V., Eggermont, J., de Meyer, M., Christensen, Søren Brøgger & Vangheluwe, P., 2017, In: Journal of Biological Chemistry. 292, 17, p. 6938-6951 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs

    Krall, J., Jensen, C. H., Bavo, F., Falk-Petersen, C. B., Haugaard, A. S., Vogensen, S. B., Tian, Y., Nittegaard-Nielsen, M., Sigurdardóttir, S. B., Kehler, J., Kongstad, Kenneth Thermann, Gloriam, David E., Clausen, Rasmus Prætorius, Harpsøe, Kasper, Wellendorph, Petrine & Frølund, Bente, 2017, In: Journal of Medicinal Chemistry. 60, 21, p. 9022-9039 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    Lithostratigraphy, geology and geochemisttry of the volcanic rocks of the Vaigat Formation on Disko and Nuussuaq, Paleocene of West Greenland

    Pedersen, Asger Ken, Larsen, L. M. & Pedersen, G. K., 2017, Copenhagen: The Geological Survey of Denmark and Greenland. 244 p. (Geological Survey of Denmark and Greenland (GEUS) Bulletin, Vol. 39).

    Research output: Book/ReportBookpeer-review

  6. Published

    Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation

    Jensen, C. M., Chow, H., Chen, M., Zhai, L., Frydenvang, Karla Andrea, Liu, H., Franzyk, Henrik & Christensen, Søren Brøgger, 2016, In: European Journal of Medicinal Chemistry. 114, p. 118-133 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    Basic characteristics and kinetics of degradation in aqueous buffer of selected diclofenac prodrugs intended for joint injection

    Mertz, Nina, Larsen, Susan Weng & Larsen, C. S., 6 Apr 2016. 1 p.

    Research output: Contribution to conferencePosterResearchpeer-review

  8. Published

    Cytochrome P450 Mediated Drug Metabolism

    Olsen, L., Jørgensen, Flemming Steen & Oostenbrink, C., 2016, New Horizons in Predictive Drug Metabolism and Pharmacokinetics. Wilson, A. G. E. (ed.). Cambridge: Royal Society of Chemistry, p. 66-78 13 p. (RSC Drug Discovery, Vol. 49).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  9. Published

    The potential of protein-nanomaterial interaction for advanced drug delivery

    Peng, Q. & Mu, Huiling, 23 Jan 2016, In: Journal of Controlled Release. 225, p. 121-132 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    Kolliphor surfactants affect solubilization and bioavailability of fenofibrate. Studies of in vitro digestion and absorption in rats.

    Berthelsen, R., Holm, R., Jacobsen, Jette, Kristensen, J., Abrahamsson, B. & Mullertz, Anette , 6 Apr 2015, In: Molecular Pharmaceutics. 12, 4, p. 1062-1071 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Thapsigargin, origin, chemistry, structure-activity relationships and prodrug development.

    Doan, T. Q. N. & Christensen, Søren Brøgger, Oct 2015, In: Current Pharmaceutical Design. 21, 38, p. 5505-5517 13 p.

    Research output: Contribution to journalReviewpeer-review

  12. Published

    Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score

    Laustsen, A. H. & Lohse, B., 15 Sep 2015, In: Toxicon. 104, p. 43-45 3 p.

    Research output: Contribution to journalLetterpeer-review

  13. Published

    Noter til Organisk Kemi for Biovidenskab: Organisk og bioorganisk kemi 2015

    Nielsen, J., 9 Feb 2015, 25 p.

    Research output: Other contributionEducation

  14. Published

    The PPARalpha agonist, fenofibrate decreases levels of anorectic N-acylethanolamines in the small intestine of mice

    Diep, T. A., Golbas, G. & Hansen, Harald S., 28 Jun 2014. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  15. Published

    Investigations and design of pyridine-2-carboxylic acid thiazol-2-ylamide analogs as methionine aminopeptidase inhibitors using 3D-QSAR and molecular docking

    Hauser, Alexander Sebastian, 1 Aug 2014, In: Medicinal Chemistry Research. 23, 8, p. 3861 3875 p.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    Development and validation of an SPE methodology combined with LC-MS/MS for the determination of four ionophores in aqueous environmental matrices

    Bak, S. A., Hansen, M., Krogh, K. A., Brandt, A., Halling-Sørensen, B. & Björklund, E., 25 Feb 2013, In: International Journal of Environmental Analytical Chemistry. 93, 14, p. 1500-1512

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    Altered anziety/depression-like behaviours in mice deficient in tetrahydrobiopterin

    Nasser, A., Birk Møller, L. & Andreasen T., Jesper, 13 Jan 2013.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  18. Published

    Organ culture of C57BL/6 mouse arteries with LPS as an in vitro model of vascular inflammation

    Outzen, E. M., Mehryar, R., Boonen, H. C. M., Nielsen, A. S. & Sheykhzade, Majid, 28 Aug 2013. 1 p.

    Research output: Contribution to conferencePosterResearch

  19. Published

    Lactate dehydrogenase assay for assessment of polycation cytotoxicity

    Parhamifar, L., Andersen, H. & Moghimi, S. M., 2013, Nanotechnology for Nucleic Acid Delivery. Vol. 948. p. 13-22 10 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  20. Exploring the solid-form landscape of pharmaceutical hydrates: transformation pathways of the sodium naproxen anhydrate-hydrate system

    Raijada, D. K., Bond, A., Larsen, F. H., Cornett, C., Qu, H. & Rantanen, J., Jan 2013, In: Pharmaceutical Research. 30, 1, p. 280-289 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    Exploring the solid-form landscape of pharmaceutical hydrates: transformation pathways of the sodium naproxen anhydrate-hydrate system

    Raijada, D. K., Bond, A., Larsen, F. H., Cornett, Claus, Qu, H. & Rantanen, Jukka, 2013, In: Pharmaceutical Research. 30, 1, p. 280-289 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Pollution Pathways of Pharmaceutical Residues in the Aquatic Environment on the Island of Mallorca, Spain

    Rodríguez-Navas, C., Björklund, E., Bak, S. A., Hansen, M., Krogh, K. A., Maya, F., Forteza, R. & Cerdà, V., 2013, In: Archives of Environmental Contamination and Toxicology. 61, 1, p. 56-66

    Research output: Contribution to journalJournal articlepeer-review

  23. Liposomal temocene (m-THPPo) photodynamic treatment induces cell death by mitochondria-independent apoptosis

    Soriano, J., Garcia-Diaz, M., Mora, M., Sagristá, M. L., Nonell, S., Villanueva, A., Stockert, J. C. & Cañete, M., 28 May 2013, In: BBA General Subjects. 1830, 10, p. 4611-4620 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  24. Published

    Pattern-oriented Agent-based Monte Carlo simulation of Cellular Redox Environment

    Tang, J., Holcombe, M. & Boonen, H. C. M., 28 Aug 2013. 1 p.

    Research output: Contribution to conferencePosterResearch

  25. Published

    Prolonged naproxen joint residence time after intra-articular injection of lipophilic solutions comprising a naproxen glycolamide ester prodrug in the rat

    Thing, M., Lu, Y., Agårdh, L., Larsen, C. S., Østergaard, Jesper, He, W., Wu, W., Larsen, F. & Larsen, Susan Weng, 15 Jul 2013, In: International Journal of Pharmaceutics. 451, 1-2, p. 34-40 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    Strategic funding priorities in the pharmaceutical sciences allied to Quality by Design (QbD) and Process Analytical Technology (PAT)

    Aksu, B., De Beer, T., Folestad, S., Ketolainen, J., Lindén, H., Lopes, J. A., de Matas, M., Oostra, W., Rantanen, Jukka & Weimer, M., 29 Sep 2012, In: European Journal of Pharmaceutical Sciences. 47, 2, p. 402-405 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Håb om at ramme latente bakterier i deres skjul

    Bahnsen, J. S., Water, J. J., Foged, Camilla, Franzyk, Henrik & Nielsen, Hanne Mørck, 2012, In: Lægemiddelforskning 2012. 2012, p. 12-14

    Research output: Contribution to journalJournal article

  28. Published

    Fast, selective, and sensitive analysis of low-abundance peptides in human plasma by electromembrane exctraction

    Balchen, M., Lund, H., Reubsaet, L. & Pedersen-Bjergaard, Stig, 2012, In: Analytica Chimica Acta. 716, p. 16-23

    Research output: Contribution to journalJournal articlepeer-review

  29. Published

    In vitro efficacy testing of praziquantel, ivermectin, and oxfendazole against Taenia Solium cysts

    Cederberg, S., Sikasunge, C. S., Andersson, Åsa & Johansen, M. V., 2012, In: Journal of Parasitology Research. 2012, 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  30. Published

    Role of excipients on solid-state properties of piroxicam during processing

    Christensen, N. P. A., Cornett, Claus & Rantanen, Jukka, 2012, In: Journal of Pharmaceutical Sciences. 101, 3, p. 1202-1211

    Research output: Contribution to journalJournal articlepeer-review

  31. Published

    Drugs for the neglected disease malaria based on natural products

    Christensen, Søren Brøgger & Bygbjerg, Ib Christian, 2012, Bioactive compounds from natural sources: natural products as lead compounds in drug discovery. Tringali, C. (ed.). 2 ed. Boca Raton: CRC Press, p. 525-550

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  32. Published

    Concise synthesis of new bridged-nicotine analogues

    Crestey, F., Hooyberghs, G. & Kristensen, Jesper Langgaard, 4 Feb 2012, In: Tetrahedron. 68, 5, p. 1417-1421

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    In vitro digestion testing of lipid-based delivery systems: calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the solubilization capacity of colloidal digestion products

    Devraj, R., Williams, H. D., Warren, D. B., Mullertz, Anette , Porter, C. J. H. & Pouton, C. W., 2012, In: International Journal of Pharmaceutics. 441, 1-2, p. 323-333

    Research output: Contribution to journalJournal articlepeer-review

  34. Published

    Multidisciplinary management of metastatic renal cell carcinoma in the era of targeted therapies

    Escudier, B., Osanto, S., Ljungberg, B., Porta, C., Wagstaff, J., Mulders, P., Gore, M., Bex, A., Bellmunt, J., Bracarda, S., Franklin, A., Honoré, P. G. H., Ravaud, A., Stein, J. V., Aziz, Z. & Akaza, H., 2012, In: Cancer Treatment Reviews. 38, 2, p. 127-132 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  35. Published

    License to kill: formulation requirements for optimal priming of CD8+ CTL responses with particulate vaccine delivery systems

    Foged, Camilla, Hansen, J. & Agger, E. M., 2012, In: European Journal of Pharmaceutical Sciences. 45, 4, p. 482-491

    Research output: Contribution to journalJournal articlepeer-review

  36. Published

    Estimating intestinal absorption of inorganic selenium compounds by in vitro flux and biotransformation studies in Caco-2 cells and ICP-MS detection

    Gammelgaard, Bente, Rasmussen, L. H., Gabel-Jensen, C. & Steffansen, B., 2012, In: Biological Trace Element Research. 145, 2, p. 248-256

    Research output: Contribution to journalJournal articlepeer-review

  37. Published

    Human urinary excretion and metabolism of 82Se-enriched selenite and selenate determined by LC-ICP-MS

    Gammelgaard, Bente, Stürup, Stefan & Christensen, M. V., 2012, In: Metallomics. 4, 2, p. 149-155

    Research output: Contribution to journalJournal articlepeer-review

  38. Published

    Volatile organic compounds in landfill ordorant emissions on the island of Mallorca

    González, C. R., Björklund, E., Forteza, R. & Cerdà, V., 2012, In: International Journal of Environmental Analytical Chemistry. 92, 12, p. 1-16, iFirst

    Research output: Contribution to journalJournal articlepeer-review

  39. Published

    Introduction to pharmaceutical chemical analysis

    Hansen, S. H., Pedersen-Bjergaard, Stig & Rasmussen, K. E., 2012, Chichester: Wiley. 477 p.

    Research output: Book/ReportBookpeer-review

  40. Published

    Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains

    Haq, S. R., Chi, C. N., Bach, Anders, Dogan, J., Engström, Å., Hultqvist, G., Karlsson, O. A., Lundström, P., Montemiglio, L. C., Strømgaard, Kristian, Gianni, S. & Jemth, P., Jan 2012, In: Journal of the American Chemical Society. 134, 1, p. 599-605

    Research output: Contribution to journalJournal articlepeer-review

  41. Published

    An electrochemical approach to protein adsorption at charged interfaces

    Hartvig, R. A., 2012, København: Det Farmaceutiske Fakultet. 127 p.

    Research output: Book/ReportPh.D. thesis

  42. Published

    Formation of dielectric layers and charge regulation in protein adsorption at biomimetic interfaces

    Hartvig, R. A., van de Weert, Marco, Østergaard, Jesper, Jørgensen, Lene & Jensen, H., 2012, In: Langmuir. 28, 3, p. 1804-1815

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    Forced degradation of therapeutic proteins

    Hawe, A., Wiggenhorn, M., van de Weert, Marco, Garbe, J. H. O., Mahler, H. & Jiskoot, W., 2012, In: Journal of Pharmaceutical Sciences. 101, 3, p. 895-913

    Research output: Contribution to journalReviewpeer-review

  44. Published

    Evaluation of the antibacterial activity of Chilean plants traditionally used for wound healing therapy against multidrug-resistant Staphylococcus aureus

    Holler, J. G., Søndergaard, K., Slotved, H., Gúzman, A. & Mølgaard, Per, Jan 2012, In: Planta Medica. 78, 2, p. 200-205

    Research output: Contribution to journalLetterpeer-review

  45. Published

    Using resin to generate a non-invasive intestinal bile-depleted rat model was unsuccessful

    Holm, R., Hesselkilde, J. Z., Jørgensen, E. B. & Mullertz, Anette , 2012, In: European Journal of Pharmaceutical Sciences. 47, p. 347-351

    Research output: Contribution to journalJournal articlepeer-review

  46. Published

    Design of an inhalable dry powder formulation of DOTAP-modified PLGA nanoparticles loaded with siRNA

    Jensen, D. M. K., Jensen, L. B., Koocheki, S., Cun, D., Nielsen, Hanne Mørck, Foged, Camilla & Bengtson, L., 2012, In: Journal of Controlled Release. 157, 1, p. 141-148

    Research output: Contribution to journalJournal articlepeer-review

  47. Published

    Comparison of polymeric siRNA nanocarriers in murine LPS-activated macrophage cell line: Gene silencing, toxicity and off-target gene expression

    Jensen, L. B., Griger, J., Naeye, B., Varkouhi, A. K., Raemdonck, K., Schiffelers, R., Lammers, T., Storm, G., Smedt, S. C. D., Sproat, B. S., Nielsen, Hanne Mørck & Foged, Camilla, 2012, In: Pharmaceutical Research. 29, p. 669-682

    Research output: Contribution to journalJournal articlepeer-review

  48. Published

    Interaction of peptidomimetics with bilayer membranes: biophysical characterization and cellular uptake

    Jing, X., Kasimova, M. R., Simonsen, A. H., Jørgensen, Lene, Malmsten, M., Franzyk, Henrik & Foged, Camilla, 2012, In: Langmuir. 28, 11, p. 5167-5175

    Research output: Contribution to journalJournal articlepeer-review

  49. Published

    Quality assessment of Tulbaghia rhizomes

    Jäger, A. & Stafford, G. I., Sep 2012, In: South African Journal of Botany. 82, p. 92-98 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  50. Published

    Tool boxes for an integrated ecological and environmental management

    Jørgensen, S. E. & Nielsen, S. N., 2012, In: Ecological Indicators. 21, p. 104-109

    Research output: Contribution to journalJournal articlepeer-review

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