Bile salts and their importance for drug absorption

Department of Pharmacy

Research output: Contribution to journal › Review › Research › peer-review

Standard

Bile salts and their importance for drug absorption. / Holm, René; Müllertz, Anette; Mu, Huiling.

In: International Journal of Pharmaceutics, Vol. 453, No. 1, 30.08.2013, p. 44-55.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Holm, R, Müllertz, A & Mu, H 2013, 'Bile salts and their importance for drug absorption', International Journal of Pharmaceutics, vol. 453, no. 1, pp. 44-55. https://doi.org/10.1016/j.ijpharm.2013.04.003

APA

Holm, R., Müllertz, A., & Mu, H. (2013). Bile salts and their importance for drug absorption. International Journal of Pharmaceutics, 453(1), 44-55. https://doi.org/10.1016/j.ijpharm.2013.04.003

Vancouver

Holm R, Müllertz A, Mu H. Bile salts and their importance for drug absorption. International Journal of Pharmaceutics. 2013 Aug 30;453(1):44-55. https://doi.org/10.1016/j.ijpharm.2013.04.003

Author

Holm, René ; Müllertz, Anette ; Mu, Huiling. / Bile salts and their importance for drug absorption. In: International Journal of Pharmaceutics. 2013 ; Vol. 453, No. 1. pp. 44-55.

Bibtex

@article{78419f676d47417e81d4465f5f1df725,

title = "Bile salts and their importance for drug absorption",

abstract = "Bile salts are present in the intestines of humans as well as the animals used during the development of pharmaceutical products. This review provides a short introduction into the physical chemical properties of bile salts, a description of the bile concentration and composition of bile in different animal species and an overview of the literature investigating the influence of bile salts on the in vivo performance of different compounds and drug formulations. Generally, there is a positive effect on bioavailability when bile is present in the gastro-intestinal tract, independent of the formulation systems, e.g. suspensions, solutions, cyclodextrin complexes or lipid based formulations, but a few exceptions have also been reported.",

author = "Ren{\'e} Holm and Anette M{\"u}llertz and Huiling Mu",

year = "2013",

month = aug,

day = "30",

doi = "10.1016/j.ijpharm.2013.04.003",

language = "English",

volume = "453",

pages = "44--55",

journal = "International Journal of Pharmaceutics",

issn = "0378-5173",

publisher = "Elsevier",

number = "1",

}

RIS

TY - JOUR

T1 - Bile salts and their importance for drug absorption

AU - Holm, René

AU - Müllertz, Anette

AU - Mu, Huiling

PY - 2013/8/30

Y1 - 2013/8/30

N2 - Bile salts are present in the intestines of humans as well as the animals used during the development of pharmaceutical products. This review provides a short introduction into the physical chemical properties of bile salts, a description of the bile concentration and composition of bile in different animal species and an overview of the literature investigating the influence of bile salts on the in vivo performance of different compounds and drug formulations. Generally, there is a positive effect on bioavailability when bile is present in the gastro-intestinal tract, independent of the formulation systems, e.g. suspensions, solutions, cyclodextrin complexes or lipid based formulations, but a few exceptions have also been reported.

AB - Bile salts are present in the intestines of humans as well as the animals used during the development of pharmaceutical products. This review provides a short introduction into the physical chemical properties of bile salts, a description of the bile concentration and composition of bile in different animal species and an overview of the literature investigating the influence of bile salts on the in vivo performance of different compounds and drug formulations. Generally, there is a positive effect on bioavailability when bile is present in the gastro-intestinal tract, independent of the formulation systems, e.g. suspensions, solutions, cyclodextrin complexes or lipid based formulations, but a few exceptions have also been reported.

U2 - 10.1016/j.ijpharm.2013.04.003

DO - 10.1016/j.ijpharm.2013.04.003

M3 - Review

C2 - 23598075

VL - 453

SP - 44

EP - 55

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1

ER -

ID: 49013481