Anti-Ageing Effects of Sonchus oleraceus L. (pūhā) Leaf Extracts on H2O2-Induced Cell Senescence

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Anti-Ageing Effects of Sonchus oleraceus L. (pūhā) Leaf Extracts on H2O2-Induced Cell Senescence. / Ou, Zong-Quan; Rades, Thomas; McDowell, Arlene.

In: Molecules, Vol. 20, No. 3, 2015, p. 4548-64.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ou, Z-Q, Rades, T & McDowell, A 2015, 'Anti-Ageing Effects of Sonchus oleraceus L. (pūhā) Leaf Extracts on H2O2-Induced Cell Senescence', Molecules, vol. 20, no. 3, pp. 4548-64. https://doi.org/10.3390/molecules20034548

APA

Ou, Z-Q., Rades, T., & McDowell, A. (2015). Anti-Ageing Effects of Sonchus oleraceus L. (pūhā) Leaf Extracts on H2O2-Induced Cell Senescence. Molecules, 20(3), 4548-64. https://doi.org/10.3390/molecules20034548

Vancouver

Ou Z-Q, Rades T, McDowell A. Anti-Ageing Effects of Sonchus oleraceus L. (pūhā) Leaf Extracts on H2O2-Induced Cell Senescence. Molecules. 2015;20(3):4548-64. https://doi.org/10.3390/molecules20034548

Author

Ou, Zong-Quan ; Rades, Thomas ; McDowell, Arlene. / Anti-Ageing Effects of Sonchus oleraceus L. (pūhā) Leaf Extracts on H2O2-Induced Cell Senescence. In: Molecules. 2015 ; Vol. 20, No. 3. pp. 4548-64.

Bibtex

@article{a3e5a8def3604d019863b27469d21cd3,
title = "Anti-Ageing Effects of Sonchus oleraceus L. (pūhā) Leaf Extracts on H2O2-Induced Cell Senescence",
abstract = "Antioxidants protect against damage from free radicals and are believed to slow the ageing process. Previously, we have reported the high antioxidant activity of 70% methanolic Sonchus oleraceus L. (Asteraceae) leaf extracts. We hypothesize that S. oleraceus extracts protect cells against H2O2-induced senescence by mediating oxidative stress. Premature senescence of young WI-38 cells was induced by application of H2O2. Cells were treated with S. oleraceus extracts before or after H2O2 stress. The senescence- associated β-galactosidase (SA-β-gal) activity was used to indicate cell senescence. S. oleraceus extracts showed higher cellular antioxidant activity than chlorogenic acid in WI-38 cells. S. oleraceus extracts suppressed H2O2 stress-induced premature senescence in a concentration-dependent manner. At 5 and 20 mg/mL, S. oleraceus extracts showed better or equivalent effects of reducing stress-induced premature senescence than the corresponding ascorbic acid treatments. These findings indicate the potential of S. oleraceus extracts to be formulated as an anti-ageing agent.",
author = "Zong-Quan Ou and Thomas Rades and Arlene McDowell",
year = "2015",
doi = "10.3390/molecules20034548",
language = "English",
volume = "20",
pages = "4548--64",
journal = "Molecules",
issn = "1420-3049",
publisher = "M D P I AG",
number = "3",

}

RIS

TY - JOUR

T1 - Anti-Ageing Effects of Sonchus oleraceus L. (pūhā) Leaf Extracts on H2O2-Induced Cell Senescence

AU - Ou, Zong-Quan

AU - Rades, Thomas

AU - McDowell, Arlene

PY - 2015

Y1 - 2015

N2 - Antioxidants protect against damage from free radicals and are believed to slow the ageing process. Previously, we have reported the high antioxidant activity of 70% methanolic Sonchus oleraceus L. (Asteraceae) leaf extracts. We hypothesize that S. oleraceus extracts protect cells against H2O2-induced senescence by mediating oxidative stress. Premature senescence of young WI-38 cells was induced by application of H2O2. Cells were treated with S. oleraceus extracts before or after H2O2 stress. The senescence- associated β-galactosidase (SA-β-gal) activity was used to indicate cell senescence. S. oleraceus extracts showed higher cellular antioxidant activity than chlorogenic acid in WI-38 cells. S. oleraceus extracts suppressed H2O2 stress-induced premature senescence in a concentration-dependent manner. At 5 and 20 mg/mL, S. oleraceus extracts showed better or equivalent effects of reducing stress-induced premature senescence than the corresponding ascorbic acid treatments. These findings indicate the potential of S. oleraceus extracts to be formulated as an anti-ageing agent.

AB - Antioxidants protect against damage from free radicals and are believed to slow the ageing process. Previously, we have reported the high antioxidant activity of 70% methanolic Sonchus oleraceus L. (Asteraceae) leaf extracts. We hypothesize that S. oleraceus extracts protect cells against H2O2-induced senescence by mediating oxidative stress. Premature senescence of young WI-38 cells was induced by application of H2O2. Cells were treated with S. oleraceus extracts before or after H2O2 stress. The senescence- associated β-galactosidase (SA-β-gal) activity was used to indicate cell senescence. S. oleraceus extracts showed higher cellular antioxidant activity than chlorogenic acid in WI-38 cells. S. oleraceus extracts suppressed H2O2 stress-induced premature senescence in a concentration-dependent manner. At 5 and 20 mg/mL, S. oleraceus extracts showed better or equivalent effects of reducing stress-induced premature senescence than the corresponding ascorbic acid treatments. These findings indicate the potential of S. oleraceus extracts to be formulated as an anti-ageing agent.

U2 - 10.3390/molecules20034548

DO - 10.3390/molecules20034548

M3 - Journal article

C2 - 25774489

VL - 20

SP - 4548

EP - 4564

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 3

ER -

ID: 135485256