Analysis of matrix dosage forms during dissolution testing using raman microscopy
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Analysis of matrix dosage forms during dissolution testing using raman microscopy. / Haaser, Miriam; Windbergs, Maike; McGoverin, Cushla M; Kleinebudde, Peter; Rades, Thomas; Gordon, Keith C; Strachan, Clare J.
In: Al Azhar Journal of Pharmaceutical Sciences, 2011.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Analysis of matrix dosage forms during dissolution testing using raman microscopy
AU - Haaser, Miriam
AU - Windbergs, Maike
AU - McGoverin, Cushla M
AU - Kleinebudde, Peter
AU - Rades, Thomas
AU - Gordon, Keith C
AU - Strachan, Clare J
N1 - Copyright © 2011 Wiley-Liss, Inc.
PY - 2011
Y1 - 2011
N2 - Matrix dosage forms are widely used for sustained drug release. As both the distribution of the matrix components and physical changes during dissolution can impact drug release behavior, a comprehensive investigation of these phenomena is required during matrix development. In this study, Raman microscopy was used to investigate different extrudate formulations in terms of component distribution and structural changes during dissolution testing. Two systems containing the model drug theophylline anhydrate were investigated: a binary system, based on a tripalmitin matrix, and a ternary system, containing tripalmitin and polyethylene glycol. The distribution of the drug and the soluble and insoluble matrix components were mapped during dissolution testing. Although a receding drug boundary was observed, it was not uniformly distant from the matrix edge. The lipid structure remained intact, whereas the water-soluble polymer rapidly dissolved and diffused from the matrix leaving a more extensive network of channels through which the dissolution medium could penetrate and the drug could diffuse. Raman mapping can be considered a useful aid in the direct analysis of multiple matrix components during drug release, and therefore a deeper understanding of factors affecting drug release can be obtained during the development of sustained-release matrices. © 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci.
AB - Matrix dosage forms are widely used for sustained drug release. As both the distribution of the matrix components and physical changes during dissolution can impact drug release behavior, a comprehensive investigation of these phenomena is required during matrix development. In this study, Raman microscopy was used to investigate different extrudate formulations in terms of component distribution and structural changes during dissolution testing. Two systems containing the model drug theophylline anhydrate were investigated: a binary system, based on a tripalmitin matrix, and a ternary system, containing tripalmitin and polyethylene glycol. The distribution of the drug and the soluble and insoluble matrix components were mapped during dissolution testing. Although a receding drug boundary was observed, it was not uniformly distant from the matrix edge. The lipid structure remained intact, whereas the water-soluble polymer rapidly dissolved and diffused from the matrix leaving a more extensive network of channels through which the dissolution medium could penetrate and the drug could diffuse. Raman mapping can be considered a useful aid in the direct analysis of multiple matrix components during drug release, and therefore a deeper understanding of factors affecting drug release can be obtained during the development of sustained-release matrices. © 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci.
U2 - 10.1002/jps.22609
DO - 10.1002/jps.22609
M3 - Journal article
C2 - 21560128
JO - Al Azhar Journal of Pharmaceutical Sciences
JF - Al Azhar Journal of Pharmaceutical Sciences
SN - 1110-1644
ER -
ID: 40339941