An antileishmanial chalcone from Chinese licorice roots

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An antileishmanial chalcone from Chinese licorice roots. / Christensen, S B; Ming, C; Andersen, L; Hjørne, U; Olsen, C E; Cornett, C; Theander, T G; Kharazmi, A.

In: Planta Medica, Vol. 60, No. 2, 1994, p. 121-3.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Christensen, SB, Ming, C, Andersen, L, Hjørne, U, Olsen, CE, Cornett, C, Theander, TG & Kharazmi, A 1994, 'An antileishmanial chalcone from Chinese licorice roots', Planta Medica, vol. 60, no. 2, pp. 121-3.

APA

Christensen, S. B., Ming, C., Andersen, L., Hjørne, U., Olsen, C. E., Cornett, C., ... Kharazmi, A. (1994). An antileishmanial chalcone from Chinese licorice roots. Planta Medica, 60(2), 121-3.

Vancouver

Christensen SB, Ming C, Andersen L, Hjørne U, Olsen CE, Cornett C et al. An antileishmanial chalcone from Chinese licorice roots. Planta Medica. 1994;60(2):121-3.

Author

Christensen, S B ; Ming, C ; Andersen, L ; Hjørne, U ; Olsen, C E ; Cornett, C ; Theander, T G ; Kharazmi, A. / An antileishmanial chalcone from Chinese licorice roots. In: Planta Medica. 1994 ; Vol. 60, No. 2. pp. 121-3.

Bibtex

@article{cd410cd0a0da11dd86a6000ea68e967b,
title = "An antileishmanial chalcone from Chinese licorice roots",
abstract = "A bioassay guided fractionation of an extract of Chinese licorice roots led to the isolation of (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-[4- hydroxy-3-(3-methyl-2-butenyl]phenyl-2-propen-1-one, which in vitro showed potent antileishmanial activity. In addition, the novel chalcone (E)-1-[2,4-dihydroxy-3-(3-methyl-2- butenyl)phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)-2-prope n-1-one was isolated from the roots. The latter compound only showed antileishmanial activity at high concentrations.",
author = "Christensen, {S B} and C Ming and L Andersen and U Hj{\o}rne and Olsen, {C E} and C Cornett and Theander, {T G} and A Kharazmi",
note = "Keywords: Animals; Antiprotozoal Agents; Chalcone; Chalcones; China; Glycyrrhiza; Leishmania donovani; Magnetic Resonance Spectroscopy; Molecular Structure; Plants, Medicinal",
year = "1994",
language = "English",
volume = "60",
pages = "121--3",
journal = "Planta Medica",
issn = "0032-0943",
publisher = "GeorgThieme Verlag",
number = "2",

}

RIS

TY - JOUR

T1 - An antileishmanial chalcone from Chinese licorice roots

AU - Christensen, S B

AU - Ming, C

AU - Andersen, L

AU - Hjørne, U

AU - Olsen, C E

AU - Cornett, C

AU - Theander, T G

AU - Kharazmi, A

N1 - Keywords: Animals; Antiprotozoal Agents; Chalcone; Chalcones; China; Glycyrrhiza; Leishmania donovani; Magnetic Resonance Spectroscopy; Molecular Structure; Plants, Medicinal

PY - 1994

Y1 - 1994

N2 - A bioassay guided fractionation of an extract of Chinese licorice roots led to the isolation of (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-[4- hydroxy-3-(3-methyl-2-butenyl]phenyl-2-propen-1-one, which in vitro showed potent antileishmanial activity. In addition, the novel chalcone (E)-1-[2,4-dihydroxy-3-(3-methyl-2- butenyl)phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)-2-prope n-1-one was isolated from the roots. The latter compound only showed antileishmanial activity at high concentrations.

AB - A bioassay guided fractionation of an extract of Chinese licorice roots led to the isolation of (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-[4- hydroxy-3-(3-methyl-2-butenyl]phenyl-2-propen-1-one, which in vitro showed potent antileishmanial activity. In addition, the novel chalcone (E)-1-[2,4-dihydroxy-3-(3-methyl-2- butenyl)phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)-2-prope n-1-one was isolated from the roots. The latter compound only showed antileishmanial activity at high concentrations.

M3 - Journal article

C2 - 8202561

VL - 60

SP - 121

EP - 123

JO - Planta Medica

JF - Planta Medica

SN - 0032-0943

IS - 2

ER -

ID: 6766658