An antileishmanial chalcone from Chinese licorice roots
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An antileishmanial chalcone from Chinese licorice roots. / Christensen, S B; Ming, C; Andersen, L; Hjørne, U; Olsen, C E; Cornett, C; Theander, T G; Kharazmi, A.
In: Planta Medica, Vol. 60, No. 2, 1994, p. 121-3.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - An antileishmanial chalcone from Chinese licorice roots
AU - Christensen, S B
AU - Ming, C
AU - Andersen, L
AU - Hjørne, U
AU - Olsen, C E
AU - Cornett, C
AU - Theander, T G
AU - Kharazmi, A
N1 - Keywords: Animals; Antiprotozoal Agents; Chalcone; Chalcones; China; Glycyrrhiza; Leishmania donovani; Magnetic Resonance Spectroscopy; Molecular Structure; Plants, Medicinal
PY - 1994
Y1 - 1994
N2 - A bioassay guided fractionation of an extract of Chinese licorice roots led to the isolation of (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-[4- hydroxy-3-(3-methyl-2-butenyl]phenyl-2-propen-1-one, which in vitro showed potent antileishmanial activity. In addition, the novel chalcone (E)-1-[2,4-dihydroxy-3-(3-methyl-2- butenyl)phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)-2-prope n-1-one was isolated from the roots. The latter compound only showed antileishmanial activity at high concentrations.
AB - A bioassay guided fractionation of an extract of Chinese licorice roots led to the isolation of (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-[4- hydroxy-3-(3-methyl-2-butenyl]phenyl-2-propen-1-one, which in vitro showed potent antileishmanial activity. In addition, the novel chalcone (E)-1-[2,4-dihydroxy-3-(3-methyl-2- butenyl)phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)-2-prope n-1-one was isolated from the roots. The latter compound only showed antileishmanial activity at high concentrations.
M3 - Journal article
C2 - 8202561
VL - 60
SP - 121
EP - 123
JO - Planta Medica
JF - Planta Medica
SN - 0032-0943
IS - 2
ER -
ID: 6766658