Additive manufacturing of prototype elements with process interfaces for continuously operating manufacturing lines: Formulation strategies and manufacturing technologies to enhance non-invasive drug delivery

Research output: Contribution to journalJournal articlepeer-review

Standard

Additive manufacturing of prototype elements with process interfaces for continuously operating manufacturing lines : Formulation strategies and manufacturing technologies to enhance non-invasive drug delivery. / Hirschberg, Cosima; Schmidt Larsen, Mikkel; Bøtker, Johan Peter; Rantanen, Jukka.

In: Asian Journal of Pharmaceutical Sciences, Vol. 13, No. 6, 2018, p. 575-583.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Hirschberg, C, Schmidt Larsen, M, Bøtker, JP & Rantanen, J 2018, 'Additive manufacturing of prototype elements with process interfaces for continuously operating manufacturing lines: Formulation strategies and manufacturing technologies to enhance non-invasive drug delivery', Asian Journal of Pharmaceutical Sciences, vol. 13, no. 6, pp. 575-583. https://doi.org/10.1016/j.ajps.2018.04.007

APA

Hirschberg, C., Schmidt Larsen, M., Bøtker, J. P., & Rantanen, J. (2018). Additive manufacturing of prototype elements with process interfaces for continuously operating manufacturing lines: Formulation strategies and manufacturing technologies to enhance non-invasive drug delivery. Asian Journal of Pharmaceutical Sciences, 13(6), 575-583. https://doi.org/10.1016/j.ajps.2018.04.007

Vancouver

Hirschberg C, Schmidt Larsen M, Bøtker JP, Rantanen J. Additive manufacturing of prototype elements with process interfaces for continuously operating manufacturing lines: Formulation strategies and manufacturing technologies to enhance non-invasive drug delivery. Asian Journal of Pharmaceutical Sciences. 2018;13(6):575-583. https://doi.org/10.1016/j.ajps.2018.04.007

Author

Hirschberg, Cosima ; Schmidt Larsen, Mikkel ; Bøtker, Johan Peter ; Rantanen, Jukka. / Additive manufacturing of prototype elements with process interfaces for continuously operating manufacturing lines : Formulation strategies and manufacturing technologies to enhance non-invasive drug delivery. In: Asian Journal of Pharmaceutical Sciences. 2018 ; Vol. 13, No. 6. pp. 575-583.

Bibtex

@article{26c145a8c7754eb9ad16b1e5b480d34b,
title = "Additive manufacturing of prototype elements with process interfaces for continuously operating manufacturing lines: Formulation strategies and manufacturing technologies to enhance non-invasive drug delivery",
abstract = "Rapid prototyping based on in silico design and 3D printing enables fast customization of complex geometries to multiple needs. This study utilizes, additive manufacturing for rapid prototyping of elements for continuously operating mixing geometries including interfaces with process analytical technology (PAT) tools, to show that 3D printing can be used for prototyping of both parts of production line and PAT interfacing solution. An additional setup was designed for measuring the dynamic calibration samples for a semi-quantitative near infrared (NIR) spectroscopic model. The powder was filled in a small calibration chamber and in-line NIR spectra of calibration samples were collected from moving material while mimicking the powder flow dynamics in a typical continuous mixer. This dynamic powder mixing system was compared with a static powder calibration model where the NIR probe was placed at different positions on a static sample. Principal component analysis (PCA) revealed that the 3D printed device with dynamic measurement of the NIR spectra had more potential for quantitative analysis. With the prototype continuous mixer, two differently placed process interfaces for NIR spectroscopic monitoring of the powder mixing were evaluated. With this approach, the importance of positioning the process analytical tools to assess the blend uniformity could be demonstrated. It was also observed that with the longer mixing geometry, a better mixing result was achieved due to a larger hold up volume and increased residence time.",
keywords = "3D printing, Continuous mixing, Near-infrared spectroscopy, Additive manufacturing",
author = "Cosima Hirschberg and {Schmidt Larsen}, Mikkel and B{\o}tker, {Johan Peter} and Jukka Rantanen",
year = "2018",
doi = "10.1016/j.ajps.2018.04.007",
language = "Dansk",
volume = "13",
pages = "575--583",
journal = "Asian Journal of Pharmaceutical Sciences",
issn = "1818-0876",
publisher = "Hong Kong Asiamed Publish House",
number = "6",

}

RIS

TY - JOUR

T1 - Additive manufacturing of prototype elements with process interfaces for continuously operating manufacturing lines

T2 - Formulation strategies and manufacturing technologies to enhance non-invasive drug delivery

AU - Hirschberg, Cosima

AU - Schmidt Larsen, Mikkel

AU - Bøtker, Johan Peter

AU - Rantanen, Jukka

PY - 2018

Y1 - 2018

N2 - Rapid prototyping based on in silico design and 3D printing enables fast customization of complex geometries to multiple needs. This study utilizes, additive manufacturing for rapid prototyping of elements for continuously operating mixing geometries including interfaces with process analytical technology (PAT) tools, to show that 3D printing can be used for prototyping of both parts of production line and PAT interfacing solution. An additional setup was designed for measuring the dynamic calibration samples for a semi-quantitative near infrared (NIR) spectroscopic model. The powder was filled in a small calibration chamber and in-line NIR spectra of calibration samples were collected from moving material while mimicking the powder flow dynamics in a typical continuous mixer. This dynamic powder mixing system was compared with a static powder calibration model where the NIR probe was placed at different positions on a static sample. Principal component analysis (PCA) revealed that the 3D printed device with dynamic measurement of the NIR spectra had more potential for quantitative analysis. With the prototype continuous mixer, two differently placed process interfaces for NIR spectroscopic monitoring of the powder mixing were evaluated. With this approach, the importance of positioning the process analytical tools to assess the blend uniformity could be demonstrated. It was also observed that with the longer mixing geometry, a better mixing result was achieved due to a larger hold up volume and increased residence time.

AB - Rapid prototyping based on in silico design and 3D printing enables fast customization of complex geometries to multiple needs. This study utilizes, additive manufacturing for rapid prototyping of elements for continuously operating mixing geometries including interfaces with process analytical technology (PAT) tools, to show that 3D printing can be used for prototyping of both parts of production line and PAT interfacing solution. An additional setup was designed for measuring the dynamic calibration samples for a semi-quantitative near infrared (NIR) spectroscopic model. The powder was filled in a small calibration chamber and in-line NIR spectra of calibration samples were collected from moving material while mimicking the powder flow dynamics in a typical continuous mixer. This dynamic powder mixing system was compared with a static powder calibration model where the NIR probe was placed at different positions on a static sample. Principal component analysis (PCA) revealed that the 3D printed device with dynamic measurement of the NIR spectra had more potential for quantitative analysis. With the prototype continuous mixer, two differently placed process interfaces for NIR spectroscopic monitoring of the powder mixing were evaluated. With this approach, the importance of positioning the process analytical tools to assess the blend uniformity could be demonstrated. It was also observed that with the longer mixing geometry, a better mixing result was achieved due to a larger hold up volume and increased residence time.

KW - 3D printing

KW - Continuous mixing

KW - Near-infrared spectroscopy

KW - Additive manufacturing

U2 - 10.1016/j.ajps.2018.04.007

DO - 10.1016/j.ajps.2018.04.007

M3 - Tidsskriftartikel

VL - 13

SP - 575

EP - 583

JO - Asian Journal of Pharmaceutical Sciences

JF - Asian Journal of Pharmaceutical Sciences

SN - 1818-0876

IS - 6

ER -

ID: 209680094