Additive manufacturing in respiratory sciences – Current applications and future prospects
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Additive manufacturing in respiratory sciences – Current applications and future prospects. / Bock, Simon; Rades, Thomas; Rantanen, Jukka; Scherließ, Regina.
In: Advanced Drug Delivery Reviews, Vol. 186, 114341, 2022.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Additive manufacturing in respiratory sciences – Current applications and future prospects
AU - Bock, Simon
AU - Rades, Thomas
AU - Rantanen, Jukka
AU - Scherließ, Regina
N1 - Funding Information: The authors acknowledge and funding from NordForsk for the Nordic University Hub project #85352 (Nordic POP, Patient Oriented Products). The authors thank Martin Wegener and Pascal Kiefer from the Karlsruhe Institute of Technology (KIT) for providing SEM images of additively manufactured particles. SB was further awarded a DDL Career Development Grant 2021 from the Aerosol Society.
PY - 2022
Y1 - 2022
N2 - Additive Manufacturing (AM) comprises a variety of techniques that enable fabrication of customised objects with specific attributes. The versatility of AM procedures and constant technological improvements allow for their application in the development of medicinal products and medical devices. This review provides an overview of AM applications related to respiratory sciences. For this purpose, both fields of research are briefly introduced and the potential benefits of integrating AM to respiratory sciences at different levels of pharmaceutical development are highlighted. Tailored manufacturing of microstructures as a particle design approach in respiratory drug delivery will be discussed. At the dosage form level, we exemplify AM as an important link in the iterative loop of data driven inhaler design, rapid prototyping and in vitro testing. This review also presents the application of bioprinting in the respiratory field for design of biorelevant in vitro cellular models, followed by an overview of AM-related processes in preventive and therapeutic care. Finally, this review discusses future prospects of AM as a component in a digital health environment.
AB - Additive Manufacturing (AM) comprises a variety of techniques that enable fabrication of customised objects with specific attributes. The versatility of AM procedures and constant technological improvements allow for their application in the development of medicinal products and medical devices. This review provides an overview of AM applications related to respiratory sciences. For this purpose, both fields of research are briefly introduced and the potential benefits of integrating AM to respiratory sciences at different levels of pharmaceutical development are highlighted. Tailored manufacturing of microstructures as a particle design approach in respiratory drug delivery will be discussed. At the dosage form level, we exemplify AM as an important link in the iterative loop of data driven inhaler design, rapid prototyping and in vitro testing. This review also presents the application of bioprinting in the respiratory field for design of biorelevant in vitro cellular models, followed by an overview of AM-related processes in preventive and therapeutic care. Finally, this review discusses future prospects of AM as a component in a digital health environment.
KW - 3D printing
KW - Airways
KW - Bioprinting
KW - Drug delivery to the lungs
KW - Inhalation
KW - Particle design
KW - Rapid Prototyping
U2 - 10.1016/j.addr.2022.114341
DO - 10.1016/j.addr.2022.114341
M3 - Review
C2 - 35569558
AN - SCOPUS:85130691595
VL - 186
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
SN - 0169-409X
M1 - 114341
ER -
ID: 309271062