A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature

Research output: Contribution to journalJournal articlepeer-review

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A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature. / Knopp, Matthias Manne; Gannon, Natasha; Porsch, Ilona; Rask, Malte Bille; Olesen, Niels Erik; Langguth, Peter; Holm, René; Rades, Thomas.

In: Journal of Pharmaceutical Sciences, Vol. 105, No. 9, 09.2016, p. 2621-2624.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Knopp, MM, Gannon, N, Porsch, I, Rask, MB, Olesen, NE, Langguth, P, Holm, R & Rades, T 2016, 'A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature', Journal of Pharmaceutical Sciences, vol. 105, no. 9, pp. 2621-2624. https://doi.org/10.1016/j.xphs.2016.02.017

APA

Knopp, M. M., Gannon, N., Porsch, I., Rask, M. B., Olesen, N. E., Langguth, P., Holm, R., & Rades, T. (2016). A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature. Journal of Pharmaceutical Sciences, 105(9), 2621-2624. https://doi.org/10.1016/j.xphs.2016.02.017

Vancouver

Knopp MM, Gannon N, Porsch I, Rask MB, Olesen NE, Langguth P et al. A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature. Journal of Pharmaceutical Sciences. 2016 Sep;105(9):2621-2624. https://doi.org/10.1016/j.xphs.2016.02.017

Author

Knopp, Matthias Manne ; Gannon, Natasha ; Porsch, Ilona ; Rask, Malte Bille ; Olesen, Niels Erik ; Langguth, Peter ; Holm, René ; Rades, Thomas. / A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature. In: Journal of Pharmaceutical Sciences. 2016 ; Vol. 105, No. 9. pp. 2621-2624.

Bibtex

@article{cd3d21c5504045c8bd3af1d94b5a44b3,
title = "A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature",
abstract = "The established methods to predict drug-polymer solubility at room temperature either rely on extrapolation over a long temperature range or are limited by the availability of a liquid analogue of the polymer. To overcome these issues, this work investigated a new methodology where the drug-polymer solubility is estimated from the solubility of the drug in a solution of the polymer at room temperature using the shake-flask method. Thus, the new polymer in solution method does not rely on temperature extrapolations and only requires the polymer and a solvent, in which the polymer is soluble, that does not affect the molecular structure of the drug and polymer relative to that in the solid state. Consequently, as this method has the potential to provide fast and precise estimates of drug-polymer solubility at room temperature, we encourage the scientific community to further investigate this principle both fundamentally and practically.",
keywords = "Journal Article",
author = "Knopp, {Matthias Manne} and Natasha Gannon and Ilona Porsch and Rask, {Malte Bille} and Olesen, {Niels Erik} and Peter Langguth and Ren{\'e} Holm and Thomas Rades",
note = "Copyright {\textcopyright} 2016 American Pharmacists Association{\textregistered}. Published by Elsevier Inc. All rights reserved.",
year = "2016",
month = sep,
doi = "10.1016/j.xphs.2016.02.017",
language = "English",
volume = "105",
pages = "2621--2624",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "9",

}

RIS

TY - JOUR

T1 - A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature

AU - Knopp, Matthias Manne

AU - Gannon, Natasha

AU - Porsch, Ilona

AU - Rask, Malte Bille

AU - Olesen, Niels Erik

AU - Langguth, Peter

AU - Holm, René

AU - Rades, Thomas

N1 - Copyright © 2016 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

PY - 2016/9

Y1 - 2016/9

N2 - The established methods to predict drug-polymer solubility at room temperature either rely on extrapolation over a long temperature range or are limited by the availability of a liquid analogue of the polymer. To overcome these issues, this work investigated a new methodology where the drug-polymer solubility is estimated from the solubility of the drug in a solution of the polymer at room temperature using the shake-flask method. Thus, the new polymer in solution method does not rely on temperature extrapolations and only requires the polymer and a solvent, in which the polymer is soluble, that does not affect the molecular structure of the drug and polymer relative to that in the solid state. Consequently, as this method has the potential to provide fast and precise estimates of drug-polymer solubility at room temperature, we encourage the scientific community to further investigate this principle both fundamentally and practically.

AB - The established methods to predict drug-polymer solubility at room temperature either rely on extrapolation over a long temperature range or are limited by the availability of a liquid analogue of the polymer. To overcome these issues, this work investigated a new methodology where the drug-polymer solubility is estimated from the solubility of the drug in a solution of the polymer at room temperature using the shake-flask method. Thus, the new polymer in solution method does not rely on temperature extrapolations and only requires the polymer and a solvent, in which the polymer is soluble, that does not affect the molecular structure of the drug and polymer relative to that in the solid state. Consequently, as this method has the potential to provide fast and precise estimates of drug-polymer solubility at room temperature, we encourage the scientific community to further investigate this principle both fundamentally and practically.

KW - Journal Article

U2 - 10.1016/j.xphs.2016.02.017

DO - 10.1016/j.xphs.2016.02.017

M3 - Journal article

C2 - 27012222

VL - 105

SP - 2621

EP - 2624

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 9

ER -

ID: 169382770