A novel method of producing a microcrystalline beta-sitosterol suspension in oil

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

A novel method of producing a microcrystalline beta-sitosterol suspension in oil. / Christiansen, Leena I; Rantanen, Jukka T; von Bonsdorff, Anna K; Karjalainen, Milja A; Yliruusi, Jouko K.

In: European Journal of Pharmaceutical Sciences, Vol. 15, No. 3, 04.2002, p. 261-9.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Christiansen, LI, Rantanen, JT, von Bonsdorff, AK, Karjalainen, MA & Yliruusi, JK 2002, 'A novel method of producing a microcrystalline beta-sitosterol suspension in oil', European Journal of Pharmaceutical Sciences, vol. 15, no. 3, pp. 261-9.

APA

Christiansen, L. I., Rantanen, J. T., von Bonsdorff, A. K., Karjalainen, M. A., & Yliruusi, J. K. (2002). A novel method of producing a microcrystalline beta-sitosterol suspension in oil. European Journal of Pharmaceutical Sciences, 15(3), 261-9.

Vancouver

Christiansen LI, Rantanen JT, von Bonsdorff AK, Karjalainen MA, Yliruusi JK. A novel method of producing a microcrystalline beta-sitosterol suspension in oil. European Journal of Pharmaceutical Sciences. 2002 Apr;15(3):261-9.

Author

Christiansen, Leena I ; Rantanen, Jukka T ; von Bonsdorff, Anna K ; Karjalainen, Milja A ; Yliruusi, Jouko K. / A novel method of producing a microcrystalline beta-sitosterol suspension in oil. In: European Journal of Pharmaceutical Sciences. 2002 ; Vol. 15, No. 3. pp. 261-9.

Bibtex

@article{e58d70bb3d1540cca9ddec7d1f1c3180,
title = "A novel method of producing a microcrystalline beta-sitosterol suspension in oil",
abstract = "This paper describes a novel method of producing a microcrystalline oral suspension containing beta-sitosterol in oil for the treatment of hypercholesterolaemia. beta-Sitosterol pseudopolymorphs with different water contents were crystallized from acetone and acetone-water solutions. Structural analyses of the crystals were performed by Karl-Fisher titration, thermogravimetric analyses, X-ray diffraction and near infrared spectroscopy. The suspensions studied were composed of different concentrations of beta-sitosterol, oil and water. Suspensions were prepared by crystallization of hot concentrated solution of beta-sitosterol in oil by cooling with simultaneous agitation and water addition. The structural analyses of the suspensions were performed by X-ray diffraction, near infrared spectroscopy and optical microscopy. The viscosity of the suspensions was analysed as a function of shear stress. beta-Sitosterol was observed to exist in three different forms: anhydrous, hemihydrated and monohydrated crystals. By changing both the beta-sitosterol and the water concentration of the suspension, the crystal size and shape could be controlled. Addition of water resulted in the formation of monohydrated needle-shaped crystals instead of platy-like anhydrous crystals. Needle-shaped particles formed structured suspensions with shear thinning behaviour. By increasing the volume fraction of solid particles in suspension by increasing the water and/or sterol concentration, the viscosity increased. A high sterol concentration resulted in high supersaturation and thus formation of small crystals.",
keywords = "Administration, Oral, Chemistry, Pharmaceutical, Crystallization, Hypercholesterolemia, Hypolipidemic Agents, Oils, Rheology, Sitosterols, Spectroscopy, Near-Infrared, Suspensions, Technology, Pharmaceutical, Thermogravimetry, X-Ray Diffraction",
author = "Christiansen, {Leena I} and Rantanen, {Jukka T} and {von Bonsdorff}, {Anna K} and Karjalainen, {Milja A} and Yliruusi, {Jouko K}",
year = "2002",
month = apr,
language = "English",
volume = "15",
pages = "261--9",
journal = "European Journal of Pharmaceutical Sciences",
issn = "0928-0987",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - A novel method of producing a microcrystalline beta-sitosterol suspension in oil

AU - Christiansen, Leena I

AU - Rantanen, Jukka T

AU - von Bonsdorff, Anna K

AU - Karjalainen, Milja A

AU - Yliruusi, Jouko K

PY - 2002/4

Y1 - 2002/4

N2 - This paper describes a novel method of producing a microcrystalline oral suspension containing beta-sitosterol in oil for the treatment of hypercholesterolaemia. beta-Sitosterol pseudopolymorphs with different water contents were crystallized from acetone and acetone-water solutions. Structural analyses of the crystals were performed by Karl-Fisher titration, thermogravimetric analyses, X-ray diffraction and near infrared spectroscopy. The suspensions studied were composed of different concentrations of beta-sitosterol, oil and water. Suspensions were prepared by crystallization of hot concentrated solution of beta-sitosterol in oil by cooling with simultaneous agitation and water addition. The structural analyses of the suspensions were performed by X-ray diffraction, near infrared spectroscopy and optical microscopy. The viscosity of the suspensions was analysed as a function of shear stress. beta-Sitosterol was observed to exist in three different forms: anhydrous, hemihydrated and monohydrated crystals. By changing both the beta-sitosterol and the water concentration of the suspension, the crystal size and shape could be controlled. Addition of water resulted in the formation of monohydrated needle-shaped crystals instead of platy-like anhydrous crystals. Needle-shaped particles formed structured suspensions with shear thinning behaviour. By increasing the volume fraction of solid particles in suspension by increasing the water and/or sterol concentration, the viscosity increased. A high sterol concentration resulted in high supersaturation and thus formation of small crystals.

AB - This paper describes a novel method of producing a microcrystalline oral suspension containing beta-sitosterol in oil for the treatment of hypercholesterolaemia. beta-Sitosterol pseudopolymorphs with different water contents were crystallized from acetone and acetone-water solutions. Structural analyses of the crystals were performed by Karl-Fisher titration, thermogravimetric analyses, X-ray diffraction and near infrared spectroscopy. The suspensions studied were composed of different concentrations of beta-sitosterol, oil and water. Suspensions were prepared by crystallization of hot concentrated solution of beta-sitosterol in oil by cooling with simultaneous agitation and water addition. The structural analyses of the suspensions were performed by X-ray diffraction, near infrared spectroscopy and optical microscopy. The viscosity of the suspensions was analysed as a function of shear stress. beta-Sitosterol was observed to exist in three different forms: anhydrous, hemihydrated and monohydrated crystals. By changing both the beta-sitosterol and the water concentration of the suspension, the crystal size and shape could be controlled. Addition of water resulted in the formation of monohydrated needle-shaped crystals instead of platy-like anhydrous crystals. Needle-shaped particles formed structured suspensions with shear thinning behaviour. By increasing the volume fraction of solid particles in suspension by increasing the water and/or sterol concentration, the viscosity increased. A high sterol concentration resulted in high supersaturation and thus formation of small crystals.

KW - Administration, Oral

KW - Chemistry, Pharmaceutical

KW - Crystallization

KW - Hypercholesterolemia

KW - Hypolipidemic Agents

KW - Oils

KW - Rheology

KW - Sitosterols

KW - Spectroscopy, Near-Infrared

KW - Suspensions

KW - Technology, Pharmaceutical

KW - Thermogravimetry

KW - X-Ray Diffraction

M3 - Journal article

C2 - 11923058

VL - 15

SP - 261

EP - 269

JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

SN - 0928-0987

IS - 3

ER -

ID: 140622846