A new approach to dissolution testing by UV imaging and finite element simulations
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A new approach to dissolution testing by UV imaging and finite element simulations. / Bøtker, Johan Peter; Rantanen, Jukka; Rades, Thomas; Müllertz, Anette; Ostergaard, Jesper; Jensen, Henrik.
In: Pharmaceutical Research, Vol. 30, No. 5, 2013, p. 1328-1337.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A new approach to dissolution testing by UV imaging and finite element simulations
AU - Bøtker, Johan Peter
AU - Rantanen, Jukka
AU - Rades, Thomas
AU - Müllertz, Anette
AU - Ostergaard, Jesper
AU - Jensen, Henrik
PY - 2013
Y1 - 2013
N2 - PURPOSE: Most dissolution testing systems rely on analyzing samples taken remotely from the dissolving sample surface at different time points with poor time resolution and therefore provide relatively unresolved temporally and spatially information on the dissolution process. In this study, a flexible numerical model was combined with a novel UV imaging system, allowing monitoring of the dissolution process with sub second time resolution. METHODS: The dissolution process was monitored by both effluent collection and UV imaging of compacts of paracetamol. A finite element model (FEM) was used to characterize the UV imaging system. RESULTS: A finite element model of the UV imaging system was successfully built. The dissolution of paracetamol was studied by UV imaging and by analysis of the effluent. The dissolution rates obtained from the collected effluent were in good agreement with the numerical model. The numerical model allowed an assessment of the ability of the UV imager to measure dissolution-time profiles. The simulation was able to extend the experimental results to conditions not easily obtained experimentally. CONCLUSIONS: Combining FEM,experimental dissolution data and UV imaging provided experimental validation of the FEM model as well as a detailed description of the dissolution process.
AB - PURPOSE: Most dissolution testing systems rely on analyzing samples taken remotely from the dissolving sample surface at different time points with poor time resolution and therefore provide relatively unresolved temporally and spatially information on the dissolution process. In this study, a flexible numerical model was combined with a novel UV imaging system, allowing monitoring of the dissolution process with sub second time resolution. METHODS: The dissolution process was monitored by both effluent collection and UV imaging of compacts of paracetamol. A finite element model (FEM) was used to characterize the UV imaging system. RESULTS: A finite element model of the UV imaging system was successfully built. The dissolution of paracetamol was studied by UV imaging and by analysis of the effluent. The dissolution rates obtained from the collected effluent were in good agreement with the numerical model. The numerical model allowed an assessment of the ability of the UV imager to measure dissolution-time profiles. The simulation was able to extend the experimental results to conditions not easily obtained experimentally. CONCLUSIONS: Combining FEM,experimental dissolution data and UV imaging provided experimental validation of the FEM model as well as a detailed description of the dissolution process.
U2 - 10.1007/s11095-013-0972-0
DO - 10.1007/s11095-013-0972-0
M3 - Journal article
C2 - 23307418
VL - 30
SP - 1328
EP - 1337
JO - Pharmaceutical Research
JF - Pharmaceutical Research
SN - 0724-8741
IS - 5
ER -
ID: 44534429