Standard
1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators. / Butini, Stefania; Pickering, Darryl S; Morelli, Elena; Coccone, Salvatore Sanna; Trotta, Francesco; De Angelis, Meri; Guarino, Egeria; Fiorini, Isabella; Campiani, Giuseppe; Novellino, Ettore; Schousboe, Arne; Christensen, Jeppe K; Gemma, Sandra.
In:
Journal of Medicinal Chemistry, Vol. 51, No. 20, 2008, p. 6614-8.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Butini, S
, Pickering, DS, Morelli, E, Coccone, SS, Trotta, F, De Angelis, M, Guarino, E, Fiorini, I, Campiani, G, Novellino, E
, Schousboe, A, Christensen, JK & Gemma, S 2008, '
1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators',
Journal of Medicinal Chemistry, vol. 51, no. 20, pp. 6614-8.
https://doi.org/10.1021/jm800865aAPA
Butini, S.
, Pickering, D. S., Morelli, E., Coccone, S. S., Trotta, F., De Angelis, M., Guarino, E., Fiorini, I., Campiani, G., Novellino, E.
, Schousboe, A., Christensen, J. K., & Gemma, S. (2008).
1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators.
Journal of Medicinal Chemistry,
51(20), 6614-8.
https://doi.org/10.1021/jm800865aVancouver
Butini S
, Pickering DS, Morelli E, Coccone SS, Trotta F, De Angelis M et al.
1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators.
Journal of Medicinal Chemistry. 2008;51(20):6614-8.
https://doi.org/10.1021/jm800865aAuthor
Butini, Stefania ; Pickering, Darryl S ; Morelli, Elena ; Coccone, Salvatore Sanna ; Trotta, Francesco ; De Angelis, Meri ; Guarino, Egeria ; Fiorini, Isabella ; Campiani, Giuseppe ; Novellino, Ettore ; Schousboe, Arne ; Christensen, Jeppe K ; Gemma, Sandra. / 1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators. In: Journal of Medicinal Chemistry. 2008 ; Vol. 51, No. 20. pp. 6614-8.
Bibtex
@article{784ada00a04211dd86a6000ea68e967b,
title = "1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators",
abstract = "(S)-CPW399 ((S)-1) is a potent and excitotoxic AMPA receptor partial agonist. Modifying the cyclopentane ring of (S)-1, we developed two of the most potent and selective functional antagonists (5 and 7) for kainate receptor (KA-R) subunit iGluR5. Derivatives 5 and 7, with their unique pharmacological profile, may lead to a better understanding of the different roles and modes of action of iGluR1-5 subunits, paving the way for the synthesis of new potent, subunit selective iGluR5 modulators.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Stefania Butini and Pickering, {Darryl S} and Elena Morelli and Coccone, {Salvatore Sanna} and Francesco Trotta and {De Angelis}, Meri and Egeria Guarino and Isabella Fiorini and Giuseppe Campiani and Ettore Novellino and Arne Schousboe and Christensen, {Jeppe K} and Sandra Gemma",
year = "2008",
doi = "10.1021/jm800865a",
language = "English",
volume = "51",
pages = "6614--8",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "20",
}
RIS
TY - JOUR
T1 - 1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators
AU - Butini, Stefania
AU - Pickering, Darryl S
AU - Morelli, Elena
AU - Coccone, Salvatore Sanna
AU - Trotta, Francesco
AU - De Angelis, Meri
AU - Guarino, Egeria
AU - Fiorini, Isabella
AU - Campiani, Giuseppe
AU - Novellino, Ettore
AU - Schousboe, Arne
AU - Christensen, Jeppe K
AU - Gemma, Sandra
PY - 2008
Y1 - 2008
N2 - (S)-CPW399 ((S)-1) is a potent and excitotoxic AMPA receptor partial agonist. Modifying the cyclopentane ring of (S)-1, we developed two of the most potent and selective functional antagonists (5 and 7) for kainate receptor (KA-R) subunit iGluR5. Derivatives 5 and 7, with their unique pharmacological profile, may lead to a better understanding of the different roles and modes of action of iGluR1-5 subunits, paving the way for the synthesis of new potent, subunit selective iGluR5 modulators.
AB - (S)-CPW399 ((S)-1) is a potent and excitotoxic AMPA receptor partial agonist. Modifying the cyclopentane ring of (S)-1, we developed two of the most potent and selective functional antagonists (5 and 7) for kainate receptor (KA-R) subunit iGluR5. Derivatives 5 and 7, with their unique pharmacological profile, may lead to a better understanding of the different roles and modes of action of iGluR1-5 subunits, paving the way for the synthesis of new potent, subunit selective iGluR5 modulators.
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1021/jm800865a
DO - 10.1021/jm800865a
M3 - Journal article
C2 - 18811139
VL - 51
SP - 6614
EP - 6618
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
SN - 0022-2623
IS - 20
ER -
