1918 pandemic H1N1 DNA vaccine protects ferrets against 2007 H1N1 virus infection

Research output: Contribution to conferencePosterResearch


  • Karoline Bragstad
  • Cyril Jean-Marie Martel
  • Bent Aasted
  • Lars Peter Nielsen
  • Anders Fomsgaard

Influenza vaccines with the ability to induce immune responses cross-reacting with drifted virus variants would be of great advantage for vaccine development against seasonal and emerging new strains. We demonstrate that gene gun administrated DNA vaccine encoding HA and NA and/or NP and M proteins of the H1N1 pandemic virus from 1918 induce protection in ferrets against infection with a H1N1 (A/New Caledonia/20/99(H1N1)) virus which was included in the conventional vaccine for the 2006-2007 season. The viruses are separated by a time interval of 89 years and differ by 21.2% in the HA1 protein. These results suggest not only a unique ability of the DNA vaccines, but perhaps also natural infection, to induce cross-protective responses against even extremely drifted virus variants.

Original languageEnglish
Publication date2008
Publication statusPublished - 2008
EventEuropean Influenza Conference - Vilamoura, Portugal
Duration: 14 Sep 200817 Sep 2008
Conference number: 3


ConferenceEuropean Influenza Conference

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