Lasse Saaby

Lasse Saaby

Affiliated Associate Professor, Guest Researcher

Member of:

    ORCID: 0000-0003-4271-8304

    Publication year:
    All
    1 - 42 out of 42Page size: 100
    1. 2024
    2. Published

      Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution

      Langthaler, Kristine, Jones, C. R., Saaby, Lasse, Bundgaard, C. & Larsen, Birger Brodin, 2024, In: Fluids and Barriers of the CNS. 21, 1, 15 p., 11.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Generation of an iPSC-line (BIONi010C-48) with restored P-glycoprotein functionality following transfection with the human MDR1 gene in the AAVS1 locus

      Nielsen, A. K. R., Lilieholm-Røngren, L., Schmid, B., Holst, B., Larsen, Birger Brodin & Saaby, Lasse, 2024, In: Stem Cell Research. 76, 5 p., 103348.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation

      Mortensen, Janni Støvring, Bohr, S. S. R., Krog, Lasse Skjoldborg, Bøtker, Johan Peter, Kapousidou, V., Saaby, Lasse, Hatzakis, Nikos, Nielsen, Hanne Mørck, Nguyen, Duc Ninh & Rønholt, Stine, 2024, In: Scientific Reports. 14, 1, 17 p., 7665.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. 2022
    6. Published

      Barrier properties of ex vivo porcine intestinal mucus are highly independent of isolation and storage conditions

      Mortensen, Janni Støvring, Saaby, Lasse, Rønholt, Stine & Nielsen, Hanne Mørck, 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 174, p. 106-110

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Insight Into the Anti-staphylococcal Activity of JBC 1847 at Sub-Inhibitory Concentration

      Ronco, T., Kappel, L. H., Aragao, M. F., Biagi, N., Svenningsen, Søren Wedel, Christensen, Jørn Bolstad, Permin, A., Saaby, Lasse, Holmstrøm, K., Klitgaard, J. K., Sabat, A. J., Akkerboom, V., Monaco, M., Tinelli, M., Friedrich, A. W., Jana, B. & Olsen, Rikke Heidemann, 2022, In: Frontiers in Microbiology. 12, 786173.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Physical and barrier changes in gastrointestinal mucus induced by the permeation enhancer sodium 8-[(2-hydroxybenzoyl)amino]octanoate (SNAC)

      Mortensen, Janni Støvring, Bohr, S. S. R., Rønholt, Stine, Hatzakis, Nikos, Saaby, Lasse & Nielsen, Hanne Mørck, 2022, In: Journal of Controlled Release. 352, p. 163-178 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. 2021
    10. Published

      Gluten Degradation, Pharmacokinetics, Safety, and Tolerability of TAK-062, an Engineered Enzyme to Treat Celiac Disease

      Pultz, I. S., Hill, M., Vitanza, J. M., Wolf, C., Saaby, Lasse, Liu, T., Winkle, P. & Leffler, D. A., Jul 2021, In: Gastroenterology. 161, 1, p. 81-93.e3

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      A new phenothiazine derivate is active against Clostridioides difficile and shows low cytotoxicity

      Ronco, T., Aragao, F. M., Saaby, Lasse, Christensen, Jørn Bolstad, Permin, A., Williams, Andrew Richard, Thamsborg, Stig Milan & Olsen, Rikke Heidemann, 2021, In: PLoS ONE. 16, 10, 13 p., e0258207.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Efficacy of a novel antimicrobial hydrogel for eradication of Staphylococcus epidermidis, Staphylococcus aureus and Cutibacterium acnes from preformed biofilm and treatment performance in an in vivo MRSA wound model

      Ronco, T., Aragao, M. F., Svenningsen, Søren Wedel, Christensen, Jørn Bolstad, Permin, A., Saaby, Lasse, Bionda, N., Lantz, E. E. & Olsen, Rikke Heidemann, 2021, In: JAC-Antimicrobial Resistance. 3, 3, 7 p., dlab108.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Human induced pluripotent stem cells (BIONi010-C) generate tight cell monolayers with blood-brain barrier traits and functional expression of large neutral amino acid transporter 1 (SLC7A5)

      Goldeman, C., Andersen, M., Al-Robai, A., Buchholtz, T., Svane, Nana Isabella, Ozgür, Burak, Holst, B., Shusta, E., Hall, Vanessa Jane, Saaby, Lasse, Hyttel, P. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutical Sciences. 156, 14 p., 105577.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice

      Ozgür, Burak, Saaby, Lasse, Janfelt, Christian, Langthaler, K., Eneberg, E., Jacobsen, A., Badolo, L., Montanari, D. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 169, p. 211-219

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. 2020
    16. Published

      IPEC-J2 rMdr1a, a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes

      Saaby, Lasse, Trasborg, J., Rasmussen, M. A., Holst, B. & Larsen, Birger Brodin, 17 Jul 2020, In: Pharmaceutics. 12, 7, 17 p., 673.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP

      Ambjørner, S. E. B., Wiese, M., Köhler, S. C., Svindt, J., Lund, X. L., Gajhede, Michael, Saaby, Lasse, Larsen, Birger Brodin, Rump, S., Weigt, H., Brünner, N. & Stenvang, Jan, 4 Mar 2020, In: Cells. 9, 3, 22 p., 613.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      A novel derivative of thioridazine shows low toxicity and efficient activity against gram‐positive pathogens

      Jørgensen, N. S., Saaby, Lasse, Andersson, A. M., Kromann, Sofie, Sheikhsamani, E., Permin, A., Ronco, T., Svenningsen, Søren Wedel, Christensen, Jørn Bolstad & Olsen, Rikke Heidemann, 2020, In: Antibiotics. 9, 6, 11 p., 327.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Drug Delivery Strategies to Overcome the Blood-Brain Barrier (BBB)

      Helms, H. C. C., Kristensen, Mie, Saaby, Lasse, Fricker, G. & Larsen, Birger Brodin, 2020, Handbook of Experimental Pharmacology. Springer, Vol. 273. p. 151-183

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

    20. 2019
    21. Published

      SEDDS for intestinal absorption of insulin: Application of Caco-2 and Caco-2/HT29 co-culture monolayers and intra-jejunal instillation in rats

      Liu, J., Werner, U., Funke, M., Besenius, M., Saaby, Lasse, Fano, M., Mu, Huiling & Mullertz, Anette , 5 Apr 2019, In: International Journal of Pharmaceutics. 560, p. 377-384

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Dark chocolate as a stable carrier of microencapsulated Akkermansia muciniphila and Lactobacillus casei

      Marcial-Coba, M. S., Saaby, Lasse, Knoechel, Susanne & Nielsen, Dennis Sandris, 2019, In: FEMS Microbiology Letters. 366, 2, p. 1-6 fny290.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. 2018
    24. Published

      The iP-gp cell model is an improved tool for predicting the in vivo relevance of P-gp mediated efflux at the blood-brain barrier

      Ozgür, Burak, Saaby, Lasse, Eneberg, E., Langthaler, K., Jacobsen, A., Janfelt, Christian, Badolo, L., Montanari, D. & Larsen, Birger Brodin, 22 Jun 2018.

      Research output: Contribution to conference › Poster › Research › peer-review

    25. Published

      Hydrolysed pea proteins mitigate in vitro wheat starch digiestibility

      López-Barón , N., Sagnelli, D., Blennow, Andreas, Holse, M., Gao, J., Saaby, Lasse, Mullertz, Anette , Jespersen, Birthe P Møller & Vasanthan, T., Jun 2018, In: Food Hydrocolloids. 79, p. 117-126 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Characterization of the IPEC-J2 MDR1 (iP-gp) cell line as a tool for identification of P-gp substrates

      Ozgür, Burak, Saaby, Lasse, Langthaler, K. & Larsen, Birger Brodin, 2018, In: European Journal of Pharmaceutical Sciences. 112, p. 112-121 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Data demonstrating the challenges of determining the kinetic parameters of P-gp mediated transport of low-water soluble substrates

      Ozgür, Burak, Saaby, Lasse, Langthaler, K. & Larsen, Birger Brodin, 2018, In: Data in Brief. 16, p. 655-659 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. 2017
    29. Published

      A Critical View on In Vitro Analysis of P-glycoprotein (P-gp) Transport Kinetics

      Saaby, Lasse & Larsen, Birger Brodin, Sep 2017, In: Journal of Pharmaceutical Sciences. 106, 9, p. 2257-2264 8 p.

      Research output: Contribution to journal › Review › Research › peer-review

    30. Published

      iP-gp , a novel cell line with tight barrier function and expression of human P-glycoprotein (ABCB1) for drug screening

      Larsen, Birger Brodin, Ozgür, Burak & Saaby, Lasse, 23 May 2017.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    31. 2016
    32. Published

      Development of a μDissolution-Permeation model with in situ drug concentration monitoring

      Berthelsen, R., Byrialsen, J. P., Holm, R., Jacobsen, Jette, Abrahamsson, B., Saaby, Lasse, Madelung, P. & Mullertz, Anette , 1 Oct 2016, In: Journal of Drug Delivery Science and Technology. 35, p. 223-233 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Apomorphine and its esters: Differences in Caco-2 cell permeability and chylomicron affinity

      Borkar, N., Chen, Z., Saaby, Lasse, Mullertz, Anette , Håkansson, A. E., Schönbeck, C., Yang, Mingshi, Holm, R. & Mu, Huiling, 6 Jun 2016, In: International Journal of Pharmaceutics. 509, 1-2, p. 499–506 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      IPEC-J2 MDR1, a Novel High-Resistance Cell Line with Functional Expression of Human P-glycoprotein (ABCB1) for Drug Screening Studies

      Saaby, Lasse, Helms, H. C. C. & Larsen, Birger Brodin, 1 Feb 2016, In: Molecular Pharmaceutics. 13, 2, p. 640-52 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Survival of Lactobacillus acidophilus NCFM® and Bifidobacterium lactis HN019 encapsulated in chocolate during in vitro simulated passage of the upper gastrointestinal tract

      Klindt-Toldam, S., Larsen, S. K., Saaby, Lasse, Olsen, L. R., Svenstrup, G., Mullertz, Anette , Knoechel, Susanne, Heimdal, H., Nielsen, Dennis Sandris & Zielińska, D., 2016, In: Lebensmittel - Wissenschaft und Technologie. 74, p. 404-410 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. 2015
    37. Published

      The putative P-gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P-glycoprotein expressing cell line MDCK II MDR1

      Saaby, Lasse, Tfelt-Hansen, P. & Larsen, Birger Brodin, 11 Jun 2015, In: Pharmacology Research & Perspectives. 3, 4, p. 1-9 9 p., e00151.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Characterization of particulate drug delivery systems for oral delivery of Peptide and protein drugs

      Christophersen, P. C., Fano, M., Saaby, Lasse, Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, 2015, In: Current Pharmaceutical Design. 21, 19, p. 2611-28 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. 2014
    40. Published

      THE POSSIBLE EFFECT OF TELMISARTAN ON THE BLOOD-BRAIN BARRIER TRANSPORT OF VERAPAMIL.

      Saaby, Lasse, Tfelt-Hansen, P. & Larsen, Birger Brodin, 18 Sep 2014. 1 p.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    41. 2013
    42. Published

      Bioavailability of cinnarizine in dogs: effect of SNEDDS loading level and correlation with cinnarizine solubilization during in vitro lipolysis

      Larsen, A. T., Åkesson, P., Juréus, A., Saaby, Lasse, Abu-Rmaileh, R., Abrahamsson, B., Østergaard, Jesper & Mullertz, Anette , Dec 2013, In: Pharmaceutical Research. 30, 12, p. 3101-13 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Considerations regarding use of solvents in in vitro cell based assays

      Timm, M., Saaby, Lasse, Moesby, L. & Hansen, E. W., Oct 2013, In: Cytotechnology. 65, 5, p. 887-894 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Current status of rational design of prodrugs targeting the intestinal di/tri-peptide transporter hPEPT1 (SLC15A1)

      Saaby, Lasse, Nielsen, C. U., Steffansen, B., Larsen, Birger Brodin & Larsen, S. B. L., 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 307–314

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. 2012
    46. Published

      Triterpene Acids from Rose Hip Powder Inhibit Self-antigen- and LPS-induced Cytokine Production and CD4(+) T-cell Proliferation in Human Mononuclear Cell Cultures

      Saaby, Lasse & Nielsen, Claus Henrik, Aug 2012, In: Phytotherapy Research. 26, 8, p. 1142-1147 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. 2011
    48. Published

      Ubiquitous plant compounds disturb cell-based assays

      Saaby, Lasse & Jäger, A. K., 1 Sep 2011, In: Journal of Ethnopharmacology. 137, 1, p. 942-943

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    49. Published

      Flavonoids and the CNS

      Jäger, A. K. & Saaby, Lasse, 10 Feb 2011, In: Molecules. 16, 2, p. 1471-1485

      Research output: Contribution to journal › Review › Research › peer-review

    50. Published

      Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.)

      Saaby, Lasse, Jäger, A. K., Moesby, L., Hansen, E. W. & Christensen, Søren Brøgger, Feb 2011, In: Phytotherapy Research. 25, 2, p. 195-201

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. Published

      Evaluation of immunomodulating and anti-inflammatory effects of a herbal remedy based on rose hip powder (Rosa canina L.)

      Saaby, Lasse, 2011, København: Det Farmaceutiske Fakultet. 130 p.

      Research output: Book/Report › Ph.D. thesis › Research

    52. 2010
    53. Published

      Characterization of anti-inflammatory triterpene acids from rose hip powder (Rosa canina L.)

      Saaby, Lasse, Jäger, A., Moesby, L., Hansen, E. W. & Christensen, Søren Brøgger, Aug 2010, In: Planta Medica. 76, 12, p. 1171

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    54. Published

      Short communication: Influence of pasteurization on the active compounds in medicinal plants to be used in dairy products

      Jäger, A. K., Saaby, Lasse, Kudsk, D. S., Witt, K. C. & Mølgaard, Per, 2010, In: Journal of Dairy Science. 93, 6, p. 2351-2353

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. 2009
    56. Published

      MAO-A inhibitory activity of quercetin from Calluna vulgaris (L.) Hull

      Saaby, Lasse, Rasmussen, H. B. & Jäger, A. K., 2009, In: Journal of Ethnopharmacology. 121, 1, p. 178-181

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. 2008
    58. Published

      MAO-A inhibitory activity of quercetin from Calluna vulgaris Hull

      Saaby, Lasse, Jäger, A. K. & Rasmussen, H. B., 2008.

      Research output: Contribution to conference › Poster › Research

    ID: 4863000