Birger Brodin Larsen

Birger Brodin Larsen

Professor


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  1. Published

    miRNA-27a-3p and miRNA-222-3p as Novel Modulators of Phosphodiesterase 3a (PDE3A) in Cerebral Microvascular Endothelial Cells

    Yasmeen, S., Kaur, S., Mirza, A. H., Larsen, Birger Brodin, Pociot, Flemming & Kruuse, Christina Rostrup, Aug 2019, In: Molecular Neurobiology. 56, 8, p. 5304–5314

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    mRNA expression and transport function of the proton-coupled amino acid transporter, PAT1, along the rat intestine

    Broberg, M. L., Larsen, K. B., Holm, R., Larsen, Birger Brodin & Nielsen, C. U., 2010.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  3. Published

    mRNA expression and transport function of the proton-coupled amino acid transporter , PAT1, along the rat intestine

    Broberg, M. L., Brandt Larsen, K., Holm, R., Larsen, Birger Brodin & Nielsen, C. U., Mar 2010. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  4. Published

    iP-gp , a novel cell line with tight barrier function and expression of human P-glycoprotein (ABCB1) for drug screening

    Larsen, Birger Brodin, Ozgür, Burak & Saaby, Lasse, 23 May 2017.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  5. Published

    hPEPT1 is responsible for uptake and transport of Gly-Sar in the human bronchial airway epithelial cell-line Calu-3

    Søndergaard, H. B., Larsen, Birger Brodin & Nielsen, C. U., 2008, In: Pflügers Archiv: European Journal of Physiology. 456, 3, p. 611-622

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    hPEPT1 Affinity and Translocation of Selected Gln-Sar and Glu-Sar Dipeptide Derivatives

    Eriksson, A. H., Elm, P. L., Begtrup, M., Nielsen, R., Steffansen, B. & Larsen, Birger Brodin, 2005, In: Molecular Pharmaceutics. 2, 3, p. 242-249

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    d-Aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1)

    Frølund, S., Marquez, O. C., Larsen, M., Larsen, Birger Brodin & Nielsen, C. U., 2010, In: British Journal of Pharmacology. 159, 6, p. 1339-1353

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Vigabatrin absorption is mediated via the proton-coupled amino acid transporter PAT1 – in vitro and in vivo

    Nøhr, M. K., Juul, R. V., Hansen, S. H., Larsen, Birger Brodin, Holm, R., Kreilgaard, M. & Nielsen, C. U., 24 Jun 2013.

    Research output: Contribution to conference › Poster › Research

  9. Published

    Validation of reference genes for normalization of real-time quantitative PCR studies of gene expression in brain capillary endothelial cells cultured in vitro

    Hersom, M., Goldeman, C., Pretzer, N. & Larsen, Birger Brodin, Dec 2018, In: Molecular and Cellular Neuroscience. 93, p. 27-35 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    VPS10P domain receptor trafficking in brain endothelial cells

    Siupka, P., Højland, A., Thomsen, L. B., Lykke-Hartmann, K., Helms, H. C. C., Larsen, Birger Brodin, Moos, T., Madsen, P. S. & Nielsen, M. S., 10 Dec 2014. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  11. Published

    Two-photon fluorescence imaging: a platform to investigate cell-penetrating peptides and liposome-based nanocarriers for drug delivery across the heterogeneous BBB in vivo

    Kucharz, K., Kristensen, K., Kristensen, Mie, Lund, M., Andresen, T., Larsen, Birger Brodin & Lauritzen, M., 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, p. 60 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  12. Published

    Transport pathways mediating blood-to-brain L-glutamate efflux

    Helms, H. C. C., Nielsen, C. U., Waagepetersen, Helle S. & Larsen, Birger Brodin, 10 Dec 2014. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  13. Published

    Transport of peptidomimetic drugs by the intestinal Di/tri-peptide transporter, PepT1

    Larsen, Birger Brodin, Nielsen, C. U., Steffansen, B. & Frøkjær, Sven, 2002, In: Basic & Clinical Pharmacology & Toxicology. 90, 6, p. 285-96 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1: Characterization of conditions for affinity and transport experiments in Caco-2 cells.

    Larsen, M., Larsen, Birger Brodin, Frølund, Bente & Nielsen, C. U., 2008, In: European Journal of Pharmaceutical Sciences. 35, 1-2, p. 86-95

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Transport of Gaboxadol via hPAT1 and rOAT1 in the absence and presence of 5-HTP

    Broberg, M. L., Holm, R., Larsen, Birger Brodin, Jensen, K. G. & Nielsen, C. U., 29 Jul 2009. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  16. Published

    Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line

    Nielsen, C. U., Supuran, C. T., Scozzafava, A., Frøkjær, Sven, Steffansen, B. & Larsen, Birger Brodin, 2002, In: Pharmaceutical Research. 19, 9, p. 1337-44 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Transport af lægemiddelstoffer gennem vævsbarrier

    Nielsen, C. U. & Larsen, Birger Brodin, 2011, Bioteknologi - en temabog. Gasbjerg, P. K., Jensen, G. S. & Sørensen, A. B. (eds.). Århus: Systime, p. 145-157 12 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education › peer-review

  18. Published

    Transferrin receptor expression and role in transendothelial transport of transferrin in cultured brain endothelial monolayers

    Hersom, M., Helms, H. C., Pretzer, N., Andersen, C. G., Jensen, A. I., Severin, G., Nielsen, M. S., Holm, R. & Larsen, Birger Brodin, 24 Aug 2016, In: Molecular and Cellular Neuroscience. 76, p. 59-67 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Transendothelial electrical resistance measurement across the blood–brain barrier: A critical review of methods

    Vigh, J. P., Kincses, A., Ozgür, Burak, Walter, F. R., Santa-Maria, A. R., Valkai, S., Vastag, M., Neuhaus, W., Larsen, Birger Brodin, Dér, A. & Deli, M. A., 2021, In: Micromachines. 12, 6, 18 p., 685.

    Research output: Contribution to journal › Review › Research › peer-review

  20. Published

    The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier

    Kurtyka, M., Wessely, F., Bau, S., Ifie, E., He, L., de Wit, N. M., Pedersen, A. B. V., Keller, M., Webber, C., de Vries, H. E., Ansorge, O., Betsholtz, C., De Bock, M., Chaves, C., Brodin, B., Nielsen, M. S., Neuhaus, W., Bell, R. D., Letoha, T., Meyer, A. H. & 7 others, Leparc, G., Lenter, M., Lesuisse, D., Cader, Z. M., Buckley, S. T., Loryan, I. & Pietrzik, C. U., 2024, In: European Journal of Cell Biology. 103, 2, 14 p., 151406.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    The putative P-gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P-glycoprotein expressing cell line MDCK II MDR1

    Saaby, Lasse, Tfelt-Hansen, P. & Larsen, Birger Brodin, 11 Jun 2015, In: Pharmacology Research & Perspectives. 3, 4, p. 1-9 9 p., e00151.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics

    Frølund, S., Holm, R., Larsen, Birger Brodin & Nielsen, C. U., 2010, In: British Journal of Pharmacology. 161, 3, p. 589-600

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    The proton-coupled amino acid transporter hPAT1 is the main transporter involved in vigabatrin uptake in intestinal Caco-2 cells

    Nøhr, M. K., Hansen, S. H., Larsen, Birger Brodin, Holm, R. & Nielsen, C. U., 30 Nov 2012.

    Research output: Contribution to conference › Poster › Research

  24. Published

    The interaction of CNS-active Amaryllidae alkaloids with the BBB efflux pump MDR1

    Eriksson, A. H., Birrer, A., Sendra, J. R., Güler, S., Rønsted, Nina, Jäger, A. K. & Larsen, Birger Brodin, 29 Jun 2010. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  25. Published

    The insulin receptor is expressed and functional in cultured blood-brain barrier endothelial cells, but does not mediate insulin entry from blood-to-brain

    Hersom, M., Helms, H. C., Schmalz, C., Pedersen, T. Å., Buckley, S. T. & Larsen, Birger Brodin, 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 315, 4, p. E531-E542

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    The insulin receptor is expressed and functional in blood-brain barrier endothelial cells, but does not mediate insulin entry from blood-to-brain

    Hersom, M. N. S., Helms, H. C. C., Pedersen, T., Buckley, S. & Larsen, Birger Brodin, 14 Sep 2016.

    Research output: Contribution to conference › Conference abstract for conference › Research

  27. Published

    The in vitro blood-brain barrier model under OGD condition

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 2 Nov 2015.

    Research output: Contribution to conference › Conference abstract for conference › Communication

  28. Published

    The iP-gp cell model is an improved tool for predicting the in vivo relevance of P-gp mediated efflux at the blood-brain barrier

    Ozgür, Burak, Saaby, Lasse, Eneberg, E., Langthaler, K., Jacobsen, A., Janfelt, Christian, Badolo, L., Montanari, D. & Larsen, Birger Brodin, 22 Jun 2018.

    Research output: Contribution to conference › Poster › Research › peer-review

  29. Published

    The human proton-coupled amino acid transporter (hPAT1) is a transport system for GABA-like drugs

    Broberg, M. L., Frølund, Bente, Larsen, Birger Brodin & Nielsen, C. U., 2007. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  30. Published

    The expression of Claudin-5 correlates with transendothelial electrical resistance (TEER) in BCEC/rat astrocyte blood-brain barrier models

    Helms, H. C. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2010.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  31. Published

    The absorptive flux of the anti-epileptic drug substance vigabatrin is carrier-mediated across Caco-2 cell monolayers

    Nøhr, M. K., Hansen, S. H., Larsen, Birger Brodin, Holm, R. & Nielsen, C. U., 23 Jan 2014, In: European Journal of Pharmaceutical Sciences. 51, p. 1-10

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP

    Ambjørner, S. E. B., Wiese, M., Köhler, S. C., Svindt, J., Lund, X. L., Gajhede, Michael, Saaby, Lasse, Larsen, Birger Brodin, Rump, S., Weigt, H., Brünner, N. & Stenvang, Jan, 4 Mar 2020, In: Cells. 9, 3, 22 p., 613.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    The F28Y substitution in the human intestinal di/tri-peptide transporter hPEPT1, causes altered pH-dependency of Gly-Sar transport

    Nielsen, C. U., Krog, P., Anderlee, P., Sadeé, W. & Larsen, Birger Brodin, 2005.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  34. Published

    The Cell-Penetrating Peptide Tat Facilitates Effective Internalization of PSD-95 Inhibitors Into Blood–Brain Barrier Endothelial Cells but less Efficient Permeation Across the Blood–Brain Barrier In Vitro and In Vivo

    Lisa Al Humaidan, E., Lund Pedersen, S., Burkhart, A., Laurfelt Munch Rasmussen, C., Moos, T., Fuchs, P., Alves Fernandes, E. F., Ozgür, Burak, Strømgaard, K., Bach, Anders, Larsen, Birger Brodin & Kristensen, Mie, 2022, In: Frontiers in Drug Delivery - CNS Drug Delivery. 2, 17 p., 854703.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions

    Imbernon, M., Saponaro, C., Helms, H. C. C., Duquenne, M., Fernandois, D., Deligia, E., Denis, R. G. P., Chao, D. H. M., Rasika, S., Staels, B., Pattou, F., Pfrieger, F. W., Larsen, Birger Brodin, Luquet, S., Bonner, C. & Prevot, V., 2022, In: Cell Metabolism. 34, 7, p. 1054-1063.e7

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Tanycytes Control the Hypothalamic Uptake and Metabolic Actions of Liraglutide

    Imbernon, M., Saponaro, C., Helms, H. C. C., Zubiaga, L., Bitsi, S., Duquenne, M., Tomas, A., Chen, S., Salem, V., Deligia, E., Gmyr, V., Denis, R., Kerr-Conte, J., Chao, D. H. M., Beiroa, D., Steals, B., Pattou, F., Pfrieger, F., Brodin, B., Jones, B. & 3 others, Luquet, S., Bonner, C. & Prevot, V., Jul 2021, In: Glia. 69, S1, p. E237-E237

    Research output: Contribution to journal › Conference abstract in journal › Research

  37. Published

    THE POSSIBLE EFFECT OF TELMISARTAN ON THE BLOOD-BRAIN BARRIER TRANSPORT OF VERAPAMIL.

    Saaby, Lasse, Tfelt-Hansen, P. & Larsen, Birger Brodin, 18 Sep 2014. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  38. Published

    Substrate-Dependent Inhibition of P-glycoprotein Mediated Efflux Transport of Digoxin

    Saaby, L., Ozgür, Burak & Larsen, Birger Brodin, 14 Nov 2017, p. T7089.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  39. Published

    Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier

    Holst, M. R., de Wit, N. M., Ozgür, Burak, Brachner, A., Hyldig, K., Appelt-Menzel, A., Sleven, H., Cader, Z., de Vries, H. E., Neuhaus, W., Jensen, A., Larsen, Birger Brodin & Nielsen, M. S., 2023, In: Fluids and Barriers of the CNS. 20, 1, 17 p., 82.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Structure and function of absorption barriers

    Larsen, Birger Brodin, Steffansen, B. & Nielsen, C. U., 2010, Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage form evaluation. Steffansen, B., Brodin, B. & Nielsen, C. U. (eds.). Pharmaceutical Press, p. 115-131 (ULLA Pharmacy Series).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  41. Published

    Stroke and Drug Delivery--In Vitro Models of the Ischemic Blood-Brain Barrier

    Tornabene, E. & Larsen, Birger Brodin, Feb 2016, In: Journal of Pharmaceutical Sciences. 105, 2, p. 398-405 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Stimulation-induced increases in cerebral blood flow and local capillary vasoconstriction depend on conducted vascular responses

    Cai, Changsi, Fordsmann, J. C., Jensen, S. H., Gesslein, B., wbh615, wbh615, Hald, B. O., Zambach, S. A., Larsen, Birger Brodin & Lauritzen, Martin, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 25, p. E5796-E5804 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Sortilin regulates blood-brain barrier integrity

    Toth, A. E., Helms, H. C., Harazin, A., Johnsen, K. B., Goldeman, C., Burkhart, A., Thomsen, M. S., Kempen, P. J., Klepe, A., Lipka, D. V., Møller, P. L., Andresen, T. L., Nyegaard, M., Moos, T., Larsen, Birger Brodin & Nielsen, M. S., 2022, In: The FEBS Journal. 289, 4, p. 1062-1079

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Sorption and mobility of ivermectin in different soils

    Krogh, K. A., Søborg, T., Larsen, Birger Brodin & Halling-Sørensen, B., 2008, In: Journal of Environmental Quality. 37, 6, p. 2202-2211

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Small transepithelial osmotic gradients affect apical sodium permeability in frog skin.

    Larsen, Birger Brodin & Nielsen, R., 1993, In: Pflugers Arch - European Journal of Physiology. 423, p. 411-417

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro

    Nielsen, C. U., Frølund, S. B., Abdulhadi, S., Sari, H., Langthaler, L., Nøhr, M. K., Kall, M. A., Larsen, Birger Brodin & Holm, R., Nov 2013, In: British Journal of Pharmacology. 170, 5, p. 1041-52 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Serotonin transporter protein (SERT) and P-glycoprotein (P-gp) binding activity of montanine and coccinine from three species of Haemanthus L. (Amaryllidaceae)

    Stafford, G. I., Birer, C., Larsen, Birger Brodin, Christensen, Søren Brøgger, Eriksson, A. H., Jäger, A. & Rønsted, Nina, Sep 2013, In: South African Journal of Botany. 88, p. 101-106 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice

    Ozgür, Burak, Saaby, Lasse, Janfelt, Christian, Langthaler, K., Eneberg, E., Jacobsen, A., Badolo, L., Montanari, D. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 169, p. 211-219

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Routes for drug translocation across the blood-brain barrier: Exploiting peptides as delivery vectors

    Kristensen, Mie & Larsen, Birger Brodin, Sep 2017, In: Journal of Pharmaceutical Sciences. 106, 9, p. 2326-2334

    Research output: Contribution to journal › Review › Research › peer-review

  50. Published

    Rises in intracellular calcium in primary brain pericytes are caused by ATP

    Jensen, S. H., Helms, H. C. C., Cai, Changsi, Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, 2016. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  51. Published

    Recent advances in therapeutic applications of human transporters

    Nielsen, C. U., Våbenø, J., Andersen, R., Larsen, Birger Brodin & Steffansen, B., 2005, In: Expert Opinion on Therapeutic Patents. 15, 2, p. 153-166 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Pyrimidine and nucleoside gamma-esters of L-Glu-Sar: synthesis, stability and interaction with hPEPT1

    Eriksson, A. H., Elm, P. L., Begtrup, M., Larsen, Birger Brodin, Nielsen, R. & Steffansen, B., 2005, In: European Journal of Pharmaceutical Sciences. 25, 1, p. 145-154 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Purinergic Signaling in Pericytes of the Blood-Brain Barrier

    Jensen, S. H., Helms, H. C. C., Jessen, S. B., Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, Jul 2015.

    Research output: Contribution to conference › Poster › Research › peer-review

  54. Published

    Proton-coupled basolateral dipeptide transport in a human intestinal cell line, Caco-2

    Larsen, Birger Brodin, Nielsen, M. J. & Nielsen, C. U., 2007. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  55. Published

    Proton dependent transport of amino acids in Caco-2 cells

    Broberg, M. L., Larsen, Birger Brodin & Nielsen, C. U., 2006. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  56. Published

    Prostaglandin E2 release from dermis regulates sodium permeability of frog skin epithelium

    RYTVED, K. A., Larsen, Birger Brodin & NIELSEN, R., 1 Jan 1995, In: Acta Physiologica Scandinavica. 153, 3, p. 263-270 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    Prostaglandin E2 release from the dermis regulates sodium permeability of frog skin epithelium

    Rytved, K. A., Larsen, Birger Brodin & Nielsen, R., 1995, In: Acta Physiologica Scandinavica. 153, p. 263-270

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism

    Thomsen, A. E., Friedrichsen, G. M., Sørensen, A. H., Andersen, R., Nielsen, C. U., Larsen, Birger Brodin, Begtrup, M., Frøkjær, Sven & Steffansen, B., 2003, In: Journal of Controlled Release. 86, 2-3, p. 279-92 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Precapillary sphincters and pericytes at first-order capillaries as key regulators for brain capillary perfusion

    Zambach, S. A., Cai, Changsi, Helms, H. C. C., Hald, B. O., Dong, Y., Fordsmann, J. C., Nielsen, R. M., Hu, J., wbh615, wbh615, Larsen, Birger Brodin & Lauritzen, Martin, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 26, e2023749118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    Potential involvement of the proton-coupled amino acid transporter PAT1 (SLC36A1) in the delivery of pharmaceutical agents

    Frølund, S. B., Nøhr, M. K., Holm, R., Larsen, Birger Brodin & Nielsen, C. U., 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 293-306

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Planternes slægtskab som skattekort til nye lægemidler

    Rønsted, Nina, Larsen, Birger Brodin, Christensen, Søren Brøgger, Eriksson, A. H. & Jäger, A. K., Dec 2010, In: Lægemiddelforskning. 2010, p. 19-21

    Research output: Contribution to journal › Journal article › Communication

  62. Published

    Phorbol Ester-Induced Metamorphosis in the Parasitic Barnacle, Loxothylacus Panopaei

    Larsen, Birger Brodin, 1997, In: Journal of the Marine Biological Association of the United Kingdom. p. 261-264

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Peptide transporters in drug delivery; The human peptide transporter 1 (hPEPT1) translocates differently charged peptides in an electrogenic manner, indicating a varying proton coupling ration

    Omkvist, D. H., Nielsen, C. U., Steffansen, B. & Larsen, Birger Brodin, May 2009. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  64. Published

    Peptide Transporters in Drug Delivery

    Larsen, Birger Brodin, Steffansen, B. & Nielsen, C. U., 2007. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  65. Published

    Passive diffusion of drug substances: the concepts of flux and permeability

    Larsen, Birger Brodin, Steffansen, B. & Nielsen, C. U., 2010, Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage form evaluation. Steffansen, B., Brodin, B. & Nielsen, C. U. (eds.). PharmaPress Ltd., p. 135-151 16 p. (ULLA Pharmacy Series).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  66. Published

    Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model

    Foged, Camilla, Larsen, Birger Brodin, Frøkjær, Sven & Sundblad, A., 2005, In: Internation Journal of Pharmaceutics. 298, 2, p. 315-22 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    Paracellular tightness and claudin-5 expression is increased in the BCEC/Astrocyte blood-brain barrier model by increasing media buffer capacity during growth

    Helms, H. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, Dec 2010, In: The AAPS Journal. 12, 4, p. 759-770

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. Published

    PAT1 (SLC36A1) shows nuclear localization and affect growth of smooth muscle cells from rats

    Jensen, A., Figueiredo-Larsen, E. M., Holm, R., Broberg, M. L., Larsen, Birger Brodin & Nielsen, C. U., Jan 2014, In: A J P: Endocrinology and Metabolism (Online). 306, p. E65-E74

    Research output: Contribution to journal › Journal article › Research › peer-review

  69. Published

    Oral Gly-Sar absorption is inhibited bu a high-affinity PEPT1 inhibitor Lys-Z-NO2-Pro

    Eriksson, A. H., Rist, G. M., Larsen, Birger Brodin & Steffansen, B., 2006. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  70. Published

    Optimization of a cell-based flourescent probe assay for measuring substrate translocation via the proton-coupled intestinal di/tri-peptide transporter hPEPT1

    Omkvist, D. H., Nielsen, C. U., Steffansen, B. & Larsen, Birger Brodin, 2007. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  71. Published

    Nitric oxide, KATP channels and endothelin-1 modulate brain pericyte function, vascular tone and neurovascular coupling

    Zambach, S. A., Cai, Changsi, Helms, H. C. C., Hald, B. O., Fordsmann, J. C., Nielsen, R. M., wbh615, wbh615, Larsen, Birger Brodin & Lauritzen, Martin, 8 Jun 2020, bioRxiv, 43 p.

    Research output: Working paper › Preprint › Research

  72. Published

    Molekylær biofarmaci - når medicinen skyder genvej!

    Gram, L. K., Omkvist, D. H., Larsen, M., Nielsen, C. U., Larsen, Birger Brodin & Steffansen, I. D., 2007, In: Lægemiddelforskning. p. 16-17

    Research output: Contribution to journal › Journal article › Communication

  73. Published

    Molecular mechanisms underlying potassium transport in an in vitro model of the blood-brain barrier

    Pedersen, K. L., Assentoft, M., Helms, H. C. C., Larsen, Birger Brodin & MacAulay, N., 12 May 2014. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  74. Published

    Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage form evaluation

    Steffansen, B., Larsen, Birger Brodin & Nielsen, C. U., 2010, Pharmaceutical Press. (ULLA Pharmacy Series).

    Research output: Book/Report › Book › Research › peer-review

  75. Published

    Modeling the ischemic blood-brain barrier; the effects of oxygen-glucose deprivation (OGD) on endothelial cells in culture

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig, Waagepetersen, Helle S. & Larsen, Birger Brodin, 19 Jun 2016.

    Research output: Contribution to conference › Conference abstract for conference › Communication

  76. Published

    Model prodrugs for the intestinal oligopeptide transporter: model drug release in aqueous solution and in various biological media

    Nielsen, C. U., Andersen, R., Larsen, Birger Brodin, Frøkjær, Sven & Steffansen, B., 2001, In: Journal of Controlled Release. 73, 1, p. 21-30 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  77. Published

    Membrane Transporters in ADME

    Steffansen, B., Nielsen, C. U. & Larsen, Birger Brodin, 2013, Transporters in drug development: discovery, optimization, clinical study and regulation. Steffansen, B. & Sugiyama, Y. (eds.). Springer Publishing Company, Vol. 7. p. 1-22 (AAPS Advances in the Pharmaceutical Sciences Series).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  78. Published

    Mechanism of decomposition of drug candidates

    Steffansen, B., Nielsen, C. U. & Larsen, Birger Brodin, 2010, Molecular Biopharmaceutics: Aspects of drug characterization, drug delivery and dosage form evaluation. Pharmaceutical Press, p. 35-48 13 p. (ULLA Pharmacy Series).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  79. Published

    Kostens sammensætning kan påvirke optagelsen af lægemiddelstoffer

    Nielsen, C. U., Frølund, S. B., Nøhr, M. K., Larsen, Birger Brodin & Holm, R., 2012, In: Lægemiddelforskning. 2012, p. 31-33

    Research output: Contribution to journal › Journal article › Communication

  80. Published

    Kinetics of decomposition in aqueous solution

    Steffansen, B., Nielsen, C. U. & Larsen, Birger Brodin, 2010, Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage form evaluation. Steffansen, B., Brodin, B. & Nielsen, C. U. (eds.). Pharmaceutical Press, p. 51-69 (ULLA Pharmacy Series).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  81. Published

    In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

    Helms, H. C. C., Abbott, N. J., Burek, M., Cecchelli, R., Couraud, P., Deli, M. A., Förster, C., Galla, H. J., Romero, I. A., Shusta, E. V., Stebbins, M. J., Vandenhaute, E., Weksler, B. & Larsen, Birger Brodin, May 2016, In: Journal of Cerebral Blood Flow and Metabolism. 36, 5, p. 862-90 29 p.

    Research output: Contribution to journal › Review › Research › peer-review

  82. Published

    Introduction

    Steffansen, B., Nielsen, C. U. & Larsen, Birger Brodin, 2010, Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage from evaluation. Steffansen, B., Brodin, B. & Uhd Nielsen, C. (eds.). London: Pharmaceutical Press, p. 1-4 4 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  83. Published

    Intracellular calcium modulates basolateral K(+)-permeability in frog skin epithelium

    Larsen, Birger Brodin, Rytved, K. A. & Nielsen, Rasmus, 1994, In: Pflügers Archiv - European Journal of Physiology. 426, 1-2, p. 171-3 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  84. Published

    Intestinal solute carriers: an overview of trends and strategies for improving oral drug absorption

    Steffansen, B., Nielsen, C. U., Larsen, Birger Brodin, Eriksson, A. H., Andersen, R. & Frøkjær, Sven, 2004, In: European Journal of Pharmaceutical Sciences. 21, 1, p. 3-16 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  85. Published

    Intestinal gaboxadol absorption via PAT1 (SLC36A1): modified absorption in vivo following co-administration of L-tryptophan

    Larsen, M., Larsen, R., Jensen, K. G., Larsen, Birger Brodin & Nielsen, C. U., 2009, In: British Journal of Pharmacology. 157, p. 1380-1389

    Research output: Contribution to journal › Journal article › Research › peer-review

  86. Published

    Insulin increases peptide transport capacity in the proximal tubule kidney cell line SKPT0193-Cl.2.

    Rquez, B., Nielsen, C. U. & Larsen, Birger Brodin, 2006. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  87. Published

    Initial Attempts of Development and Characterization of an In Vitro Blood Brain Barrier Model Derived from Human Pluripotent Stem Cells

    Goldeman, C., Saaby, L., Hall, Vanessa Jane, Hyttel, P. & Larsen, Birger Brodin, 8 Dec 2016. 1 p.

    Research output: Contribution to conference › Poster › Research › peer-review

  88. Published

    In-vitro models of the blood brain barrier

    Larsen, Birger Brodin, Helms, H. C. C., Groth, S., Waagepetersen, Helle S. & Nielsen, C. U., 2012. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  89. Published

    In-vitro evaluation of the P-glycoprotein interactions of a series of potentially CNS-active Amaryllidaceae alkaloids

    Eriksson, A. H., Rønsted, Nina, Jäger, A. K., Sendra, J. R. & Larsen, Birger Brodin, 2012, In: Journal of Pharmacy and Pharmacology. 64, 11, p. 1667-1677 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  90. Published

    In-depth evaluation of Gly-Sar transport parameters as a function of culture time in the Caco-2 cell model

    Bravo, S. A., Nielsen, C. U., Amstrup, J., Frøkjær, Sven & Larsen, Birger Brodin, 1 Jan 2004, In: European Journal of Pharmaceutical Sciences. 21, 1, p. 77-86 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  91. Published

    In vitro models for investigating the function of proton-coupled amino acid transporter 1 (PAT1, SLC36A19)

    Jensen, A., Larsen, Birger Brodin & Nielsen, C. U., 2010. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  92. Published

    In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells co-cultured with astrocytes display a polarized brain-to-blood transport of glutamate

    Helms, H. C. C., Madelung, R., Groth, S., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 13 Sep 2012. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  93. Published

    In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells cocultured with astrocytes display a polarized brain-to-blood transport of glutamate

    Helms, H. C., Madelung, R., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2012, In: Glia. 60, 6, p. 882-893

    Research output: Contribution to journal › Journal article › Research › peer-review

  94. Published

    In vitro evaluation of N-methyl amide tripeptidomimetics as substrates for the human intestinal di-/tri-peptide transporter hPEPT1

    Andersen, R., Nielsen, C. U., Begtrup, M., Jørgensen, Flemming Steen, Larsen, Birger Brodin, Frøkjær, Sven & Steffansen, B., 2006, In: European Journal of Pharmaceutical Sciences. 28, 4, p. 325-35 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  95. Published

    In vitro blood-brain barrier permeability predictions for GABAA receptor modulating piperine analogs

    Eigenmann, D. E., Dürig, C., Jähne, E. A., Smieško, M., Culot, M., Gosselet, F., Cecchelli, R., Helms, H. C. C., Larsen, Birger Brodin, Wimmer, L., Mihovilovic, M. D., Hamburger, M. & Oufir, M., Jun 2016, In: European Journal of Pharmaceutics and Biopharmaceutics. 103, p. 118-26 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  96. Published

    In vitro blood-brain barrier models

    Helms, H. C. C., Eriksson, A. H., Nielsen, C. U., Waagepetersen, Helle S. & Larsen, Birger Brodin, 18 Jul 2009.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  97. Published

    In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt(1)-DALDA Analogues

    Ballet, S., Betti, C., Novoa, A., Tömböly, C., Nielsen, C. U., Helms, H. C., Lesniak, A., Kleczkowska, P., Chung, N. N., Lipkowski, A. W., Larsen, Birger Brodin, Tourwé, D. & Schiller, P. W., 10 Apr 2014, In: ACS Medicinal Chemistry Letters. 5, 4, p. 352-357 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  98. Published

    In Vitro Blood-Brain Barrier Models-An Overview of Established Models and New Microfluidic Approaches

    Wolff, A., Antfolk, M., Larsen, Birger Brodin & Tenje, M., 28 Jan 2015, In: Journal of Pharmaceutical Sciences. 104, 9, p. 2727-2746 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  99. Published

    Identification and Characterization of a Novel Nontranslated Sequence Variant of the Human Intestinal Di-/Tripeptide Transporter, hPEPT1

    Søndergaard, H. B., Nielsen, C. U. & Larsen, Birger Brodin, 31 Dec 2012, In: International Journal of Peptides. 2012, 2012, 7 p., 743472.

    Research output: Contribution to journal › Journal article › Research › peer-review

  100. Published

    Ibuprofen is an inhibitor of hPEPT1: Implications for drug-drug interactions at the level of drug absorption

    Omkvist, D. H., Larsen, Birger Brodin & Nielsen, C. U., Mar 2010. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

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