Birger Brodin Larsen
Professor
CNS Drug Delivery and Barrier Modelling
Universitetsparken 2
2100 København Ø
- Published
Basolateral peptide transport in intestinal cells is pH dependent
Juul Nielsen, M., Nielsen, C. U. & Larsen, Birger Brodin, 2007. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Routes for drug translocation across the blood-brain barrier: Exploiting peptides as delivery vectors
Kristensen, Mie & Larsen, Birger Brodin, Sep 2017, In: Journal of Pharmaceutical Sciences. 106, 9, p. 2326-2334Research output: Contribution to journal › Review › Research › peer-review
- Published
Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation
Kristensen, Mie, Kucharz, Krzysztof, Alves Fernandes, Eduardo Felipe, Strømgaard, Kristian, Schallburg Nielsen, M., Cederberg Helms, H. C., Bach, Anders, Ulrikkaholm Tofte-Hansen, M., Aldana, Blanca, Lauritzen, Martin & Larsen, Birger Brodin, 2020, In: Pharmaceutics. 12, 7, 24 p., 661.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sorption and mobility of ivermectin in different soils
Krogh, K. A., Søborg, T., Larsen, Birger Brodin & Halling-Sørensen, B., 2008, In: Journal of Environmental Quality. 37, 6, p. 2202-2211Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Two-photon fluorescence imaging: a platform to investigate cell-penetrating peptides and liposome-based nanocarriers for drug delivery across the heterogeneous BBB in vivo
Kucharz, K., Kristensen, K., Kristensen, Mie, Lund, M., Andresen, T., Larsen, Birger Brodin & Lauritzen, M., 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, p. 60 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier
Kurtyka, M., Wessely, F., Bau, S., Ifie, E., He, L., de Wit, N. M., Pedersen, A. B. V., Keller, M., Webber, C., de Vries, H. E., Ansorge, O., Betsholtz, C., De Bock, M., Chaves, C., Brodin, B., Nielsen, M. S., Neuhaus, W., Bell, R. D., Letoha, T., Meyer, A. H. & 7 others, , 2024, In: European Journal of Cell Biology. 103, 2, 14 p., 151406.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies
Langthaler, Kristine, Jones, C. R., Christensen, R. B., Eneberg, E., Larsen, Birger Brodin & Bundgaard, C., 2022, In: Xenobiotica. 52, 6, p. 591-607Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution
Langthaler, Kristine, Jones, C. R., Saaby, Lasse, Bundgaard, C. & Larsen, Birger Brodin, 2024, In: Fluids and Barriers of the CNS. 21, 1, 15 p., 11.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Assessing extent of brain penetration in vivo (Kp,uu,brain) in Göttingen minipig using a diverse set of reference drugs
Langthaler, Kristine, Jones, C. R., Larsen, Birger Brodin & Bundgaard, C., 2023, In: European Journal of Pharmaceutical Sciences. 190, 11 p., 106554.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure and function of absorption barriers
Larsen, Birger Brodin, Steffansen, B. & Nielsen, C. U., 2010, Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage form evaluation. Steffansen, B., Brodin, B. & Nielsen, C. U. (eds.). Pharmaceutical Press, p. 115-131 (ULLA Pharmacy Series).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Intestinal gaboxadol absorption via PAT1 (SLC36A1): modified absorption in vivo following co-administration of L-tryptophan
Larsen, M., Larsen, R., Jensen, K. G., Larsen, Birger Brodin & Nielsen, C. U., 2009, In: British Journal of Pharmacology. 157, p. 1380-1389Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1: Characterization of conditions for affinity and transport experiments in Caco-2 cells.
Larsen, M., Larsen, Birger Brodin, Frølund, Bente & Nielsen, C. U., 2008, In: European Journal of Pharmaceutical Sciences. 35, 1-2, p. 86-95Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of ligands for the human intestinal di-/tripeptide transporter (hPEPT1) using af QSAR-assisted virtual screening strategy
Larsen, S. B., Omkvist, D. H., Larsen, Birger Brodin, Nielsen, C. U., Steffansen, B., Olsen, L. & Jørgensen, Flemming Steen, 2009, In: ChemMedChem. 4, 9, p. 1439-1445Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Cell-Penetrating Peptide Tat Facilitates Effective Internalization of PSD-95 Inhibitors Into Blood–Brain Barrier Endothelial Cells but less Efficient Permeation Across the Blood–Brain Barrier In Vitro and In Vivo
Lisa Al Humaidan, E., Lund Pedersen, S., Burkhart, A., Laurfelt Munch Rasmussen, C., Moos, T., Fuchs, P., Alves Fernandes, E. F., Ozgür, Burak, Strømgaard, K., Bach, Anders, Larsen, Birger Brodin & Kristensen, Mie, 2022, In: Frontiers in Drug Delivery - CNS Drug Delivery. 2, 17 p., 854703.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evaluating the involvement of cerebral microvascular endothelial Na+/K+-ATPase and Na+-K+-2Cl- co-transporter in electrolyte fluxes in an in vitro blood-brain barrier model of dehydration
Lykke, K., Assentoft, M., Hørlyck, S., Helms, H. C. C., Stoica, A., Toft-Bertelsen, Trine Lisberg, Tritsaris, Katerina, Vilhardt, Frederik, Larsen, Birger Brodin & MacAulay, Nanna, 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 3, p. 497-512Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In Vitro cutaneous application of ISCOMs on human skin enhances delivery of hydrophobic model compounds through the stratum corneum
Madsen, H. B., Ifversen, P., Madsen, F., Larsen, Birger Brodin, Hausser, I. & Nielsen, Hanne Mørck, 2009, In: The AAPS Journal. 11, 4, p. 728-739Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evidence for a Na+/Ca2+ exchange mechanism in frog skin epithelium
Madsen, K. H., Larsen, Birger Brodin & Nielsen, Rasmus, 1999, In: Pflügers Archiv - European Journal of Physiology. 437, 2, p. 175-81 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Generation of an iPSC-line (BIONi010C-48) with restored P-glycoprotein functionality following transfection with the human MDR1 gene in the AAVS1 locus
Nielsen, A. K. R., Lilieholm-Røngren, L., Schmid, B., Holst, B., Larsen, Birger Brodin & Saaby, Lasse, 2024, In: Stem Cell Research. 76, 5 p., 103348.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line
Nielsen, C. U., Andersen, R., Larsen, Birger Brodin, Frøkjær, Sven, Taub, M. E. & Steffansen, B., 2001, In: Journal of Controlled Release. 76, 1-2, p. 129-38 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epidermal growth factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line
Nielsen, C. U., Amstrup, J., Steffansen, B., Frøkjær, Sven & Larsen, Birger Brodin, 2001, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 281, 1, p. G191-9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Di/tri-peptide transporters as drug delivery targets: regulation of transport under physiological and patho-physiological conditions
Nielsen, C. U. & Larsen, Birger Brodin, 2003, In: Current Drug Targets. 4, 5, p. 373-88 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Model prodrugs for the intestinal oligopeptide transporter: model drug release in aqueous solution and in various biological media
Nielsen, C. U., Andersen, R., Larsen, Birger Brodin, Frøkjær, Sven & Steffansen, B., 2001, In: Journal of Controlled Release. 73, 1, p. 21-30 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line
Nielsen, C. U., Supuran, C. T., Scozzafava, A., Frøkjær, Sven, Steffansen, B. & Larsen, Birger Brodin, 2002, In: Pharmaceutical Research. 19, 9, p. 1337-44 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABA transport across the basolateral membrane of intestinal cells
Nielsen, C. U., Carstensen, M. & Larsen, Birger Brodin, 2010. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Transport af lægemiddelstoffer gennem vævsbarrier
Nielsen, C. U. & Larsen, Birger Brodin, 2011, Bioteknologi - en temabog. Gasbjerg, P. K., Jensen, G. S. & Sørensen, A. B. (eds.). Århus: Systime, p. 145-157 12 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education › peer-review
- Published
Carrier-mediated transport kinetics
Nielsen, C. U., Steffansen, B. & Larsen, Birger Brodin, 2010, Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage form evaluation. Pharmaceutical Press, p. 153-173Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Human peptide transporters: Therapeutic applications
Nielsen, C. U., Larsen, Birger Brodin, Jørgensen, Flemming Steen, Frøkjær, Sven & Steffansen, B., 1 Sep 2002, In: Expert Opinion on Therapeutic Patents. 12, 9, p. 1329-1350 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Absorptive transporters
Nielsen, C. U., Steffansen, B. & Larsen, Birger Brodin, 2010, Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage from evaluation. Steffansen, B., Brodin, B. & Uhd Nielsen, C. (eds.). London: Pharmaceutical Press, p. 193-211 (ULLA Pharmacy Series).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Carrier-mediated ¿-aminobutyric acid transport across the basolateral membrane of human intestinal Caco-2 cell monolayers
Nielsen, C. U., Carstensen, M. & Larsen, Birger Brodin, 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 81, 2, p. 458-462Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Application of Cell Culture and Tissue Models for Assessing Drug Transport
Nielsen, C. U. & Larsen, Birger Brodin, 2016, Analytical Techniques in the Pharmaceutical Sciences. Müllertz, A., Perrie, Y. & Rades, T. (eds.). Springer, p. 791-821 30 p. (Advances in Delivery Science and Technology; No. 1).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro
Nielsen, C. U., Frølund, S. B., Abdulhadi, S., Sari, H., Langthaler, L., Nøhr, M. K., Kall, M. A., Larsen, Birger Brodin & Holm, R., Nov 2013, In: British Journal of Pharmacology. 170, 5, p. 1041-52 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recent advances in therapeutic applications of human transporters
Nielsen, C. U., Våbenø, J., Andersen, R., Larsen, Birger Brodin & Steffansen, B., 2005, In: Expert Opinion on Therapeutic Patents. 15, 2, p. 153-166 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Kostens sammensætning kan påvirke optagelsen af lægemiddelstoffer
Nielsen, C. U., Frølund, S. B., Nøhr, M. K., Larsen, Birger Brodin & Holm, R., 2012, In: Lægemiddelforskning. 2012, p. 31-33Research output: Contribution to journal › Journal article › Communication
- Published
The F28Y substitution in the human intestinal di/tri-peptide transporter hPEPT1, causes altered pH-dependency of Gly-Sar transport
Nielsen, C. U., Krog, P., Anderlee, P., Sadeé, W. & Larsen, Birger Brodin, 2005.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Efflux transporters
Nielsen, C. U., Larsen, Birger Brodin & Steffansen, B., 2010, Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage form evaluation. Steffansen, B., Brodin, B. & Uhd Nielsen, C. (eds.). Pharmaceutical Press, p. 213-22Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Carrier-mediated dipeptide transport in a human lung epithelial cell line, Calu-3
Nielsen, C. U., Søndergaard, H. B. & Larsen, Birger Brodin, 2006. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Basolateral peptid etransport in the human intestinal cell line Caco-2 is proton-coupled
Nielsen, M. J., Nielsen, C. U. & Larsen, Birger Brodin, 2008. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells
Nielsen, S. S. E., Holst, M. R., Langthaler, Kristine, Bruun, E. H., Larsen, Birger Brodin & Nielsen, M. S., 2023, In: Fluids and Barriers of the CNS. 20, 1, 15 p., 2.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The proton-coupled amino acid transporter hPAT1 is the main transporter involved in vigabatrin uptake in intestinal Caco-2 cells
Nøhr, M. K., Hansen, S. H., Larsen, Birger Brodin, Holm, R. & Nielsen, C. U., 30 Nov 2012.Research output: Contribution to conference › Poster › Research
- Published
The absorptive flux of the anti-epileptic drug substance vigabatrin is carrier-mediated across Caco-2 cell monolayers
Nøhr, M. K., Hansen, S. H., Larsen, Birger Brodin, Holm, R. & Nielsen, C. U., 23 Jan 2014, In: European Journal of Pharmaceutical Sciences. 51, p. 1-10Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Vigabatrin absorption is mediated via the proton-coupled amino acid transporter PAT1 – in vitro and in vivo
Nøhr, M. K., Juul, R. V., Hansen, S. H., Larsen, Birger Brodin, Holm, R., Kreilgaard, M. & Nielsen, C. U., 24 Jun 2013.Research output: Contribution to conference › Poster › Research
- Published
Design of prodrugs targeting the intestinal di/tri‐peptide transporter hPEPT1 (SLC15A1
Omkvist, D. H., Nielsen, C. U., Steffansen, B., Larsen, S. B., Olsen, L., Jørgensen, Flemming Steen & Larsen, Birger Brodin, 4 Apr 2014. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Peptide transporters in drug delivery; The human peptide transporter 1 (hPEPT1) translocates differently charged peptides in an electrogenic manner, indicating a varying proton coupling ration
Omkvist, D. H., Nielsen, C. U., Steffansen, B. & Larsen, Birger Brodin, May 2009. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Ibuprofen is a non-competitive inhibitor of the peptide transporter hPEPT1 (SLC15A1): possible interactions between hPEPT1 substrates and ibuprofen
Omkvist, D. H., Larsen, Birger Brodin & Nielsen, C. U., 2010, In: British Journal of Pharmacology. 161, 8, p. 1793-1805Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A quantitative structure-activity relationship for translocation of tripeptides via the human proton-coupled peptide transporter, hPEPT1 (SLC15A1)
Omkvist, D. H., Larsen, S. B., Nielsen, C. U., Steffansen, B., Olsen, L., Jørgensen, Flemming Steen & Larsen, Birger Brodin, 2010, In: The AAPS Journal. 12, 3, p. 385-396Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Optimization of a cell-based flourescent probe assay for measuring substrate translocation via the proton-coupled intestinal di/tri-peptide transporter hPEPT1
Omkvist, D. H., Nielsen, C. U., Steffansen, B. & Larsen, Birger Brodin, 2007. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Ibuprofen is an inhibitor of hPEPT1: Implications for drug-drug interactions at the level of drug absorption
Omkvist, D. H., Larsen, Birger Brodin & Nielsen, C. U., 2010.Research output: Contribution to conference › Poster › Research
- Published
Ibuprofen is an inhibitor of hPEPT1: Implications for drug-drug interactions at the level of drug absorption
Omkvist, D. H., Larsen, Birger Brodin & Nielsen, C. U., Mar 2010. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Affinity and translocation relationships via hPEPT1 of H-Xaa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs
Omkvist, D. H., Trangbæk, D. J., Mildon, J., Paine, J. S., Larsen, Birger Brodin, Begtrup, M. & Nielsen, C. U., 2011, In: European Journal of Pharmaceutics and Biopharmaceutics. 77, 2, p. 327-331Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice
Ozgür, Burak, Saaby, Lasse, Janfelt, Christian, Langthaler, K., Eneberg, E., Jacobsen, A., Badolo, L., Montanari, D. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 169, p. 211-219Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1299175
Most downloads
-
1525
downloads
Design of prodrugs targeting the intestinal di/tri‐peptide transporter hPEPT1 (SLC15A1
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Published -
245
downloads
A bovine in vitro blood-brain barrier model under oxygenglucose deprivation (OGD) condition
Research output: Contribution to conference › Poster › Research
Published