Anette Müllertz

Anette Müllertz

Professor

Member of:


    1. Published

      pH-triggered drug release from biodegradable microwells for oral drug delivery

      Nielsen, L. H., Nagstrup, J., Gordon, S., Keller, S. S., Østergaard, Jesper, Rades, Thomas, Mullertz, Anette & Boisen, A., Jun 2015, In: Biomedical Microdevices. 17, 7 p., 55.

      Research output: Contribution to journalJournal articlepeer-review

    2. Published

      X-ray Imaging for Gastrointestinal Tracking of Microscale Oral Drug Delivery Devices

      Kjeldsen, R. B., Kristensen, M. N., Gundlach, C., Thamdrup, L. H. E., Mullertz, Anette , Rades, Thomas, Nielsen, L. H., Zór, K. & Boisen, A., 2021, In: ACS Biomaterials Science and Engineering. 7, 6, p. 2538–2547

      Research output: Contribution to journalJournal articlepeer-review

    3. Published

      Visualizing the Journey of Fenofibrate through the Rat Gastrointestinal Tract by Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging

      Strindberg, S., Plum, J., Bagger, C., Janfelt, Christian & Mullertz, Anette , 2021, In: Molecular Pharmaceutics. 18, 6, p. 2189–2197

      Research output: Contribution to journalJournal articlepeer-review

    4. Published

      Using resin to generate a non-invasive intestinal bile-depleted rat model was unsuccessful

      Holm, R., Hesselkilde, J. Z., Jørgensen, E. B. & Mullertz, Anette , 2012, In: European Journal of Pharmaceutical Sciences. 47, p. 347-351

      Research output: Contribution to journalJournal articlepeer-review

    5. Published

      Using in vitro lipolysis and SPECT/CT in vivo imaging to understand oral absorption of fenofibrate from lipid-based drug delivery systems

      Tran, T., Bonlokke, P., Rodriguez-Rodriguez, C., Nosrati, Z., Esquinas, P. L., Borkar, N., Plum, J., Strindberg, S., Karagiozov, S., Rades, Thomas, Mullertz, Anette , Saatchi, K. & Hafeli, U. O., 2020, In: Journal of Controlled Release. 317, p. 375-384

      Research output: Contribution to journalJournal articlepeer-review

    6. Published

      Using in vitro dynamic lipolysis modeling as a tool for exploring IVIVC relationships for oral lipid-based formulations

      Mullertz, Anette & Fatourus, D. G., 2007, Oral lipid-based formulations: enhancing the bioviabillity of poorly water-soluble drugs. Hauss, D. J. (ed.). New York: Informa healtcare, p. 257-272

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

    7. Published

      Using biorelevant dissolution to obtain IVIVC of solid dosage forms containing a poorly-soluble model compound

      Lue, B., Nielsen, F. S., Magnussen, T., Schou, H. M., Kristensen, K., Jacobsen, L. O. & Mullertz, Anette , 2008, In: European Journal of Pharmaceutics and Biopharmaceutics. 69, 2, p. 648-657

      Research output: Contribution to journalJournal articlepeer-review

    8. Published

      Using Potentiometric Free Drug Sensors to Determine the Free Concentration of Ionizable Drugs in Colloidal Systems

      Tran, T., Chakraborty, A., Xi, X., Bohets, H., Cornett, Claus, Tsinman, K., Rades, Thomas & Mullertz, Anette , Jan 2018, In: Journal of Pharmaceutical Sciences. 107, 1, p. 103-112

      Research output: Contribution to journalJournal articlepeer-review

    9. Published

      Unravelling the ultrastructure of ascending colon fluids from patients with ulcerative colitis by cryogenic transmission electron microscopy

      Mullertz, Anette , Fatouros, D. G., Vertzoni, M. & Reppas, C., Oct 2013, In: The Journal of pharmacy and pharmacology. 65, 10, p. 1482-7 6 p.

      Research output: Contribution to journalJournal articlepeer-review

    10. Published

      UNGAP best practice for improving solubility data quality of orally administered drugs

      Vertzoni, M., Alsenz, J., Augustijns, P., Bauer-Brandl, A., Bergström, C. A. S., Brouwers, J., Mullertz, Anette , Perlovich, G., Saal, C., Sugano, K. & Reppas, C., 1 Jan 2022, In: European Journal of Pharmaceutical Sciences. 168, 21 p., 106043.

      Research output: Contribution to journalJournal articlepeer-review

    11. Published

      Trilaurin diminishes food effect on the release of desmopressin from solid lipid microparticles

      Christophersen, P., Vaghela, D., Mullertz, Anette , Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, 2014.

      Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

    12. Published

      Towards the understanding of complex fluids in pharmaceutical sciences

      Pedersen, P. B., Pekka Pajander, J., Mullertz, Anette , Vilmann, Peter, Jørgensen, Lene & Baldursdottir, S. G., 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 393 401 p.

      Research output: Contribution to journalJournal articlepeer-review

    13. Published

      Towards the development of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) containing trimethyl chitosan for the oral delivery of amphotericin B: In vitro assessment and cytocompatibility studies

      Kontogiannidou, E., Meikopoulos, T., Virgiliou, C., Bouropoulos, N., Gika, H., Vizirianakis, I. S., Mullertz, Anette & Fatouros, D. G., Apr 2020, In: Journal of Drug Delivery Science and Technology. 56, 9 p., 101524.

      Research output: Contribution to journalJournal articlepeer-review

    14. Published

      Towards analyzing the potential of exosomes to deliver microRNA therapeutics

      Giassafaki, L. N., Siqueira, S., Panteris, E., Psatha, K., Chatzopoulou, F., Aivaliotis, M., Tzimagiorgis, G., Mullertz, Anette , Fatouros, D. G. & Vizirianakis, I. S., 2021, In: Journal of Cellular Physiology. 236, 2, p. 1529-1544 16 p.

      Research output: Contribution to journalJournal articlepeer-review

    15. Published

      Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: proposing a new lipid formulation performance classification system

      Williams, H. D., Sassene, P., Kleberg, K., Calderone, M., Igonin, A., Jule, E., Vertommen, J., Blundell, R., Benameur, H., Mullertz, Anette , Porter, C. J. H., Pouton, C. W. & Communicated on Behalf of the LFCS Consortium, C. O. B. O. T. L. C., Aug 2014, In: Journal of Pharmaceutical Sciences. 103, 8, p. 2441-55 15 p.

      Research output: Contribution to journalJournal articlepeer-review

    16. Published

      Toward the establishment of standardized in vitro tests for lipid-based formulations, part 3: understanding supersaturation versus precipitation potential during the in vitro digestion of type I, II, IIIA, IIIB and IV lipid-based formulations

      Williams, H. D., Sassene, P., Kleberg, K., Calderone, M., Igonin, A., Jule, E., Vertommen, J., Blundell, R., Benameur, H., Mullertz, Anette , Pouton, C. W., Porter, C. J. H. & LFCS Consortium, L. C., Dec 2013, In: Pharmaceutical Research. 30, 12, p. 3059-76 18 p.

      Research output: Contribution to journalJournal articlepeer-review

    17. Published

      Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: Method parameterization and comparison of in vitro digestion profiles across a range of representative formulations

      Williams, H. D., Sassene, P., Kleberg, K., Bakala-N'Goma, J., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Carrière, F., Mullertz, Anette , Porter, C. J. H. & Pouton, C. W., 2012, In: Journal of Pharmaceutical Sciences. 101, 9, p. 3360-3380

      Research output: Contribution to journalJournal articlepeer-review

    18. Published

      Toward the Establishment of Standardized in Vitro Tests for Lipid-Based Formulations. 2. The Effect of Bile Salt Concentration and Drug Loading on the Performance of Type I, II, IIIA, IIIB, and IV Formulations during in Vitro Digestion

      Williams, H. D., Anby, M. U., Sassene, P., Kleberg, K., Bakala-N’Goma, J., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Carrière, F., Mullertz, Anette , Pouton, C. W. & Porter, C. J. H., 2012, In: Molecular Pharmaceutics. 9, 11, p. 3286-3300 15 p.

      Research output: Contribution to journalJournal articlepeer-review

    19. Published

      Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase

      Bakala-N'Goma, J., Williams, H. D., Sassene, P. J., Kleberg, K., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Mullertz, Anette , Pouton, C. W., Porter, C. J. H. & Carriere, F., Apr 2015, In: Pharmaceutical Research. 32, 4, p. 1279-1287 9 p.

      Research output: Contribution to journalJournal articlepeer-review

    20. Published

      The use of biorelevant dissolution media in determining the region of microemulsion: Implications for in vitro lipid formulation assessment

      Ogbonna, A., Ren, S., Olesen, P. & Mullertz, Anette , 2009.

      Research output: Contribution to conferencePosterResearch

    21. Published

      The ability of two in vitro lipolysis models reflecting the human and rat gastro-intestinal conditions to predict the in vivo performance of SNEDDS dosing regimens

      Jorgensen, S. D. S., Al Sawaf, M., Graeser, K., Mu, Huiling, Mullertz, Anette & Rades, Thomas, Mar 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 124, p. 116-124

      Research output: Contribution to journalJournal articlepeer-review

    22. Published

      The Influence of Solidification on the in vitro Solubilisation of Blonanserin Loaded Supersaturated Lipid-Based Oral Formulations

      Moller, A., Schultz, H. B., Meola, T. R., Mullertz, Anette & Prestidge, C. A., 2021, In: European Journal of Pharmaceutical Sciences. 157, 10 p., 105640.

      Research output: Contribution to journalJournal articlepeer-review

    23. Published

      The Influence of Polymers on the Supersaturation Potential of Poor and Good Glass Formers

      Blaabjerg, L. I., Grohganz, Holger, Lindenberg, E., Löbmann, K., Mullertz, Anette & Rades, Thomas, 21 Sep 2018, In: Pharmaceutics. 10, 4, 14 p., 164.

      Research output: Contribution to journalJournal articlepeer-review

    24. Published

      The Influence of Blonanserin Supersaturation in Liquid and Silica Stabilised Self-Nanoemulsifying Drug Delivery Systems on In Vitro Solubilisation

      Møller, Amalie Lykkemark, Schultz, H. B., Meola, T. R., Joyce, P., Mullertz, Anette & Prestidge, C. A., 2023, In: Pharmaceutics. 15, 1, 14 p., 284.

      Research output: Contribution to journalJournal articlepeer-review

    25. Published

      The Effect of Digestion and Drug Load on Halofantrine Absorption from Self-nanoemulsifying Drug Delivery System (SNEDDS)

      Michaelsen, M. H., Wasan, K. M., Sivak, O., Mullertz, Anette & Rades, Thomas, Jan 2016, In: The A A P S Journal. 18, 1, p. 180-186 7 p.

      Research output: Contribution to journalJournal articlepeer-review

    26. Published

      The Binding of Alpinia galanga Oil and Its Nanoemulsion to Mammal GABA(A) Receptors Using Rat Cortical Membranes and an In Silico Modeling Platform

      Khumpirapang, N., Suknuntha, K., Wongrattanakamon, P., Jiranusornkul, S., Anuchapreeda, S., Wellendorph, Petrine, Mullertz, Anette , Rades, Thomas & Okonogi, S., 2022, In: Pharmaceutics. 14, 3, 15 p., 650.

      Research output: Contribution to journalJournal articlepeer-review

    27. Published

      Tabletter med løse ender

      Naelapaa, K., Mullertz, Anette , Jacobsen, Jette, Rømsing, J. & Bar-Shalom, Daniel, 2009, In: Lægemiddelforskning. p. 4-6

      Research output: Contribution to journalJournal article

    28. Published

      Tabletter med "løse ender" giver forsinket afgift af lægemiddelstof

      Naelapaa, K., Mullertz, Anette , Jacobsen, Jette, Rømsing, J. & Bar-Shalom, Daniel, 2009, In: Lægemiddelforskning. p. 4-6 3 p.

      Research output: Contribution to journalJournal article

    29. Published

      Survival of Lactobacillus acidophilus NCFM® and Bifidobacterium lactis HN019 encapsulated in chocolate during in vitro simulated passage of the upper gastrointestinal tract

      Klindt-Toldam, S., Larsen, S. K., Saaby, Lasse, Olsen, L. R., Svenstrup, G., Mullertz, Anette , Knøchel, Susanne, Heimdal, H., Nielsen, Dennis Sandris & Zielińska, D., 2016, In: Lebensmittel - Wissenschaft und Technologie. 74, p. 404-410 7 p.

      Research output: Contribution to journalJournal articlepeer-review

    30. Published

      Supersaturation of zafirlukast in fasted and fed state intestinal media with and without precipitation inhibitors

      Madsen, C. M., Boyd, B., Rades, Thomas & Mullertz, Anette , 25 Aug 2016, In: European Journal of Pharmaceutical Sciences. 91, p. 31-39 9 p.

      Research output: Contribution to journalJournal articlepeer-review

    31. Published

      Supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS) enhance the bioavailability of the poorly water-soluble drug Simvastatin in dogs

      Thomas, N., Holm, R., Garmer, M., Karlsson, J. J., Mullertz, Anette & Rades, Thomas, 2013, In: A A P S Journal. 15, 1, p. 219-27 9 p.

      Research output: Contribution to journalJournal articlepeer-review

    32. Published

      Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

      Boyd, B. J., Bergström, C. A. S., Vinarov, Z., Kuentz, M., Brouwers, J., Augustijns, P., Brandl, M., Bernkop-Schnürch, A., Shrestha, N., Préat, V., Mullertz, Anette , Bauer-Brandl, A. & Jannin, V., 2019, In: European Journal of Pharmaceutical Sciences. 137, 27 p., 104967.

      Research output: Contribution to journalJournal articlepeer-review

    33. Published

      Studying the propensity of compounds to supersaturate: a practical and broadly applicable approach

      Palmelund, H., Madsen, C. M., Christensen, J. P., Mullertz, Anette & Rades, Thomas, Oct 2016, In: Journal of Pharmaceutical Sciences. 105, 10, p. 3021-3029 9 p.

      Research output: Contribution to journalJournal articlepeer-review

    34. Published

      Studying furosemide solubilization using an in vitro model simulating gastrointestinal digestion and drug solubilization in neonates and young infants

      Klitgaard, Mette, Sassene, P. J., Selen, A., Mullertz, Anette & Berthelsen, R., 15 Nov 2017, In: European Journal of Pharmaceutical Sciences. 109, p. 191-199 9 p.

      Research output: Contribution to journalJournal articlepeer-review

    35. Published

      Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats

      Holm, R., Porter, C. J. H., Mullertz, Anette , Kristensen, H. G. & Charman, W. N., 2002, In: Pharmaceutical Research. 19, 9, p. 1354-61 7 p.

      Research output: Contribution to journalJournal articlepeer-review

    36. Published

      Structured approach for designing drug-loaded solid products by binder jetting 3D printing

      Wang, Y., Mullertz, Anette & Rantanen, Jukka, 2022, In: European Journal of Pharmaceutical Sciences. 178, 11 p., 106280.

      Research output: Contribution to journalJournal articlepeer-review

    37. Published

      Structural features of colloidal species in the human fasted upper small intestine

      Mullertz, Anette , Reppas, C., Psachoulias, D., Vertzoni, M. & Fatouros, D. G., Apr 2015, In: Journal of Pharmacy and Pharmacology. 67, 4, p. 486-492 7 p.

      Research output: Contribution to journalJournal articlepeer-review

    38. Published

      Structural development of self nano emulsifying drug delivery systems (SNEDDS) during in vitro lipid digestion monitored by small-angle X-ray scattering

      Fatouros, D. G., Deen, R., Arleth, Lise, Bergenstahl, B., Nielsen, F. S., Pedersen, J. S. & Mullertz, Anette , 2007, In: Pharmaceutical Research. 24, 10, p. 1844-1853 10 p.

      Research output: Contribution to journalJournal articlepeer-review

    39. Published

      Steric and interactive barrier properties of intestinal mucus elucidated by particle diffusion and peptide permeation

      Bøgh, M., García-Díaz, M., Mullertz, Anette & Nielsen, Hanne Mørck, Sep 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 94, Part A, p. 136–143 8 p.

      Research output: Contribution to journalJournal articlepeer-review

    40. Published

      Stability and intrinsic dissolution of vacuum compression molded amorphous solid dispersions of efavirenz

      Jørgensen, J. R., Mohr, W., Rischer, M., Sauer, A., Mistry, S., Mullertz, Anette & Rades, Thomas, 2023, In: International Journal of Pharmaceutics. 632, 8 p., 122564.

      Research output: Contribution to journalJournal articlepeer-review

    41. Published

      Stabilisation of amorphous furosemide increases the oral drug bioavailability in rats

      Nielsen, L. H., Rades, Thomas & Mullertz, Anette , 25 Jul 2015, In: International Journal of Pharmaceutics. 490, 1-2, p. 334-40 7 p.

      Research output: Contribution to journalJournal articlepeer-review

    42. Published

      Spatial confinement can lead to increased stability of amorphous indomethacin

      Nielsen, L. H., Keller, S. S., Gordon, K. C., Boisen, A., Rades, Thomas & Mullertz, Anette , 2012, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 81, 2, p. 418-25 8 p.

      Research output: Contribution to journalJournal articlepeer-review

    43. Published

      Solution or suspension - Does it matter for lipid based systems? In vivo studies of chase dosing lipid vehicles with aqueous suspensions of a poorly soluble drug

      Larsen, A. T., Holm, R. & Mullertz, Anette , Aug 2017, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 117, p. 308-314 7 p.

      Research output: Contribution to journalJournal articlepeer-review

    44. Published

      Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols

      Christensen, J. Ø., Schultz, K., Mollgaard, B., Kristensen, H. G. & Mullertz, Anette , 2004, In: European Journal of Pharmaceutical Sciences. 23, 3, p. 287-96 9 p.

      Research output: Contribution to journalJournal articlepeer-review

    45. Published

      Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin

      Christophersen, P. C., Vaghela, D., Mullertz, Anette , Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, Jul 2014, In: A A P S Journal. 16, 4, p. 875-83 9 p.

      Research output: Contribution to journalJournal articlepeer-review

    46. Published

      Solid lipid particles for oral delivery of peptide and protein drugs I - Elucidating the release mechanism of lysozyme during lipolysis

      Christophersen, P. C. B., Zhang, L., Yang, Mingshi, Nielsen, Hanne Mørck, Mullertz, Anette & Mu, Huiling, 2 Aug 2013, In: European Journal of Pharmaceutics and Biopharmaceutics. 85, 3, part A, p. 473-480

      Research output: Contribution to journalJournal articlepeer-review

    47. Published

      Solid forms of amlodipine besylate: Physiochemical, structural, and thermodynamic characterization

      Koradia, V. S., Lopez de Diego, H., Frydenvang, Karla Andrea, Ringkjøbing-Elema, M., Mullertz, Anette , Bond, A. D. & Rantanen, Jukka, 28 Oct 2010, In: Crystal Growth & Design. 10, 12, p. 5279-5290

      Research output: Contribution to journalJournal articlepeer-review

    48. Published

      Solid cellulose nanofiber based foams - Towards facile design of sustained drug delivery systems

      Svagan, A. J., Benjamins, J., Al-Ansari, Z., Bar-Shalom, Daniel, Mullertz, Anette , Wågberg, L. & Löbmann, K., 12 Nov 2016, In: Journal of controlled release : official journal of the Controlled Release Society. 244 , Part A, p. 74–82 9 p.

      Research output: Contribution to journalJournal articlepeer-review

    49. Published

      Solid Lipid Particles for Oral Delivery of Peptide and Protein Drugs II - The Digestion of Trilaurin Protects Desmopressin from Proteolytic Degradation

      Christophersen, P. C., Zhang, L., Mullertz, Anette , Nielsen, Hanne Mørck, Yang, Mingshi & Mu, Huiling, 13 Mar 2014, In: Pharmaceutical Research. 31, 9, p. 2420-28 9 p.

      Research output: Contribution to journalJournal articlepeer-review

    50. Published

      Six years of progress in the oral biopharmaceutics area – A summary from the IMI OrBiTo project

      Abrahamsson, B., Mcallister, M., Augustijns, P., Zane, P., Butler, J., Holm, R., Langguth, P., Lindahl, A., Mullertz, Anette , Pepin, X., Rostami-hodjegan, A., Sjögren, E., Berntsson, M. & Lennernäs, H., 1 Jul 2020, In: European Journal of Pharmaceutics and Biopharmaceutics. 152, p. 236-247 12 p.

      Research output: Contribution to journalJournal articlepeer-review

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