Biologics Seminar Series October 2019

The Biologics Seminar series is a programme of seminars organised by the Vaccine Design and Delivery group at the Department of Pharmacy. Each time, a different speaker is invited to present their work for one hour.

Program

Dr. Andrew Urquhart, PhD, Associate Professor, Group Leader, Ocular Drug Delivery, DTU Health Tech, Technical University of Denmark will speak about Retina neuroprotection with biologic loaded liposome.​

Abstract

Optic neuropathies, such as glaucoma, are a leading cause of irreversible vision loss and blindness worldwide. Optic neuropathies are characterized by the loss of retinal ganglion cells (RGCs). RGCs transmit visual and non-visual information from the retina to the brain. As there is no regenerative capacity in the mammalian retina, RGC loss is irreversible. Nerve grafts and retina transplant are either surgically unfeasible or have had poor success. Small molecule therapeutics have also struggled in inhibiting RGC loss. Direct delivery or genetic overexpression of neuroprotective growth factors has shown promise in retina neuroprotection. Inspired by this work, we have recently developed multifarious biologic loaded liposomes that stimulate multiple stages of cell growth and survival signaling pathways as a strategy for retina neuroprotection. Here I will present our current retina neuroprotective liposome research covering our chosen biologics, formulation, cell biology and in vivo studies. 

Brief biography

Andrew Urquhart received his MChem (2001) from the University of St Andrews and his PhD in Physical Chemistry (2005) from the University of Cambridge. After completing his PhD, Andrew worked as a postdoctoral researcher in the School of Pharmacy at the University of Nottingham. In 2008, Andrew was joint-appointed as an assistant professor (lecturer) at the Strathclyde Institute of Pharmacy and Biomedical Sciences and The Glasgow Centre for Physical Organic Chemistry. In 2014, Andrew was appointed as an associate professor at DTU Nanotech, Technical University of Denmark. As of 2019, Andrew is an associate professor at DTU Health Tech, Technical University of Denmark. Andrew's current research focus is the development of lipid and protein based nanomedicine strategies for the treatment of neurological and neurovascular diseases of the retina.   

The seminar will last for 45 min + 15 min questions, and is free of charge. Please contact Aneesh Thakur for further information.​