Flow-induced dispersion analysis (FIDA) – University of Copenhagen

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Department of Pharmacy > Research > Section of Pharmaceutical Design and Drug Delivery > Pharmaceutical and Physical Chemistry Group > Flow-induced dispersio...

 

Rapid quantification of protein based biomarkers by Flow-induced dispersion analysis (FIDA)

In this project we explore the possibility of using dispersion in miniaturized flow systems as a novel approach to quantify protein based biomarkers. The new approach termed Flow Induced Dispersion Analysis (FIDA) is based on the change in diffusivity of a binding specific indicator molecule (may also be termed ligand or tracer) when it interacts selectively with an analyte.

The FIDA method is rapid, requires only very limited sample amount and is relatively easy to automate. FIDA is currently being tested as a new approach for quantifying antibodies of relevance in autoimmune diseases such as Systemic Lupus Erythematous (SLE) and Rheumatoid Arthritis (RA).

The FIDA project is supported by the Danish Research Council for Independent Research, Technology and Production Sciences (FTP), grant number 11-106647.