Department of Pharmacy > Research > Section of Pharmaceutical Design and Drug Delivery > Pharmaceutical and Phy...

Pharmaceutical and Physical Chemistry Group

Physicochemical approaches for the understanding of processes in drug delivery, e.g. parenteral depot design, profiling of drugs and biomarkers as well as analytical approaches for in vitro release testing.

Projects in this group

• Design of parenteral sustained release drug delivery systems

  Development of injectable depots focusing on in situ forming formulations for subcutaneous and intra-articular administration. Suspensions, prodrugs, salts, lipophilic solutions and liquid crystalline phases.
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• Rapid quantification of protein based biomarkers by Flow-induced dispersion analysis (FIDA)

  Development of diagnostic platforms for rapid quantification of biomarkers as well as for drug characterization utilizing Taylor dispersion analysis/flow induced dispersion analysis.
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• In vitro release and dissolution testing

  Methods to assess drug/depot performance. Release kinetics and transport processes studied by dialysis-based and flow-through methods, UV imaging and finite element simulation.
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• Lipid-based nano-structured drug delivery systems

  Formulation of drug nanocarriers based on lyotropic liquid crystalline particles (cubosomes, hexosomes, micellar cubosomes): nanostructural characterization by SAXS and Cryo-TEM.
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• Physicochemical profiling of drug substances and drug delivery systems

  New/miniaturized methodologies for characterization and bioanalysis of drugs. Drug interactions, distribution and adsorption studied by electrochemistry at Interfaces-between-Immiscible-Electrolyte-Solutions (ITIES), capillary electrophoresis and flow induced dispersion analysis.
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Pharmaceutical and Physical Chemistry Group