Thiol-ene based protein biochips: A novel, versatile tool for bioanalytical research – University of Copenhagen

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Department of Pharmacy > Research > Section of Analytical Biosciences > Microscale Analytical Systems > Thiol-ene based protein

Thiol-ene based protein biochips: A novel, versatile tool for bioanalytical research

Our aim is to develop new technology to create mass producible, cheap, robust and disposable protein biochips for applications in biopharmaceutical analysis, proteomics, clinical diagnostics, drug discovery, and the in-vitro characterization of biochemical activities.
Biochips featuring immobilized biomolecules such as antibodies, antigens or enzymes, are central to many biotechnological applications. For example, biopharmaceuticals, such as protein and nucleic acid based drugs, are among the fastest growing class of drugs developed today by the pharmaceutical industry.
The biochips will be based entirely on thiol-ene photo-chemistry, providing mild reaction conditions, site-specificity, high spatial resolution, multiplexing possibilities and eliminating lengthy, expensive and labour-intensive functionalization steps associated with glass-based biochips.
The novel biochips will greatly reduce analysis time, sample preparation steps and sample consumption for this type of analysis.