Department of Pharmacy > Research > Section of Analytical Biosciences > Metallomics Lab

Metallomics Lab

Metallomics is the science of analysis of the entirety of metal and metalloid compounds in a cell or tissue type - mapping all metal-containing compounds, including free metal ions, metal-organic compounds and protein-bound metals. Such studies provide knowledge of both the beneficial and the adverse effects of metals in health and disease.
Our research interest is to gain knowledge of the uptake, distribution, metabolism and excretion of metals and metal-based drugs, by developing advanced analytical techniques capable of delivering this information.
Instrumental methods include LC-ICPMS, CE-ICPMS and LC-MS.

• Metal-based Drugs

  Development of analytical methods for the separation, detection and identification of metal-based drugs (e.g. cisplatin or oxaliplatin) and their metabolites in serum or cancer cell lines.
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• Selenium Metabolism

  Elucidation of the role of selenium and its metabolites in cancer and obesity by speciation analysis of biological samples as tissue preparations, biological fluids and cell lines.
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• Quantification of Proteins and Peptides in Drug Formulations

  Development of improved methods for quantification of pharmaceutical biomolecules for characterization of peptide and protein based drug candidates in drug delivery systems.
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• Mechanism of Resistance to Platinum Anticancer Drugs

  Development of analytical methods for determination of the mechanism of resistance to platinum anticancer drugs with the purpose of improving cancer treatment.
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• Trace Element Impurities in Drug Products

  Development and validation of inorganic mass spectroscopy-based analytical methods (ICPMS) for determination of trace elements in drug products and the compliance with current pharmacopeia requirements.
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Metallomics Lab