Department of Pharmacy > Research > Section of Analytical Biosciences > Drug Metabolism Lab

Drug Metabolism Lab

Focus is on reactive drug metabolites, xenobiotica metabolism in insects, characterisation of transporters in the blood brain barrier and on miniaturisation technologies in analytical chemistry.

• Mass spectrometry imaging

  Mass spectrometry imaging applied for studies in pharmacology and plant science.
  >>
  

• Insects for Drug Discovery

  Metabolic enzymes as well as transporters are studied in insects (primarily locusts) in order to support the development of Insects as models in drug discovery. Of special focus is the suitability of locusts as models for transport across the blood brain barrier.
  >>
  

• Reactive drug metabolites disposition in fat

  With special emphasis on the bio-synthesis and metabolism of xenobiotic acylglycerols, we investigate the mechanisms, by which drugs and drug metabolites are incorporated in and released from adipose tissue.
  >>
  

• Bioanalysis and identification of metabolites

  In the drug metabolism lab we hold the expertise and technology to provide valid analytical results for identification and quantification of drugs and drug related substances in biologically derived samples.
  >>
  

• Electromembrane extraction devices for studying drug metabolism

  In collaboration with Oslo University we have developed an extraction device that allows us to monitor drug metabolism in real time from an in-vitro incubation chamber directly coupled to mass spectrometry.
  >>
  

• Capillary electrophoresis - electrospray ionization mass spectrometry, CE-ESI-MS

  Recently we developed a new and robust CE-ESI-MS interface. The interface is “plug and play” and with basically no dead-volume at the electric contact that is supplied only 6 mm from the ESI spray tip.
  >>
  

• Metabonomics in Drug Metabolism and Plant Medicine

  Data driven studies on biofluids and plant material in relation to drug metabolism and profiling of medicinal plants are carried out. Current focus is on combining the approach with pharmaco-kinetic and pharmaco-dynamic studies and profiling of Cinchona genus.
  >>
  

• Cinchona Bark - A Study in Alkaloids.

  Malaria has plagued humanity for ages. In the 17th century bark from the Cinchona tree(s) was brought to the attention of western culture. This project profiles different cinchona species based on alkaloid content and is part of a larger project. The different species will also be evaluated for their anti-malarial potency.
  >>
  

• Age Determination of Mammals in the Arctic ocean

  When biologists need to calculate sustainable quota for an animal species it is important to have a solid knowledge of the species and its biology. Of special importance is knowledge of the habitats, number of individuals and age distribution of individual populations. Tissue samples from the eye of mammals are analysed to determine the age of individual animals.
  >>