Protein Analysis Group publishes a paper in Nature Communications

The paper “Conformational dynamics of the human serotonin transporter during substrate and drug binding” is the work from Ingvar Möller’s PhD thesis, an outcome of a long-standing collaboration between Prof. Kasper Rand and Prof. Claus Løland (Molecular Neuropharmacology Group, Department of Neuroscience and Pharmacology). The human serotonin transporter (hSERT) is an important drug target in the treatment of multiple mental diseases, and is here studied by use of hydrogen/deuterium exchange mass spectrometry (HDX-MS). The published data provides insights into the conformational dynamics of hSERT in solution and how these dynamics are impacted by the binding of biologically relevant substrate and ions (5-HT, Na+, K+), and drug inhibitors, and may possibly contribute to the development of future drug strategies. The work furthermore highlights the applicability of using HDX-MS to study the dynamic structure-function relationship and drug binding of complex protein systems like the human membrane transport proteins.