Center for Biopharmaceuticals and Biobarriers in Drug Delivery – University of Copenhagen

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Department of Pharmacy > Research > BioDelivery Center

Center for Biopharmaceuticals and Biobarriers in Drug Delivery

About the Center for Biopharmaceuticals and Biobarriers in Drug Delivery

The aim

Oral delivery of biopharmaceuticals is a grand challenge, which - when appropriately solved - will have tremendous societal impact. Our aim is to address the challenge by providing a new understanding of how biopharmaceuticals interact with and transport across mucus and epithelial barriers.
We will develop new concepts as well as new technologies and methods for designing and studying oral drug delivery systems (DDS) for biopharmaceuticals.

Our concept is to direct molecular interactions of the components in DDS, as well as to elucidate the mechanisms for interaction of both the biopharmaceuticals, excipient(s), and the DDS itself with mucus and epithelial membranes in biophysical and real-time transport studies.

Through an interdisciplinary research collaboration we will combine long-standing experience in drug delivery and advanced formulation design with expertise in cutting-edge peptide and protein chemistry, nanobiophotonics, and advanced bioimaging. Specifically, we will chemically tailor structurally complicated drugs and control their properties at the nano-scale.

We will design and synthesize new excipients that can be combined into novel, tailored drug delivery systems. We will use innovative light-driven microrobotics that can deposit nano-drug systems with unprecedented precision onto biological membranes.
Finally, we will perform comprehensive in vivo bioimaging studies of the developed DDS.

This center is funded for a duration of six years by the Novo Nordisk Foundation via its Challenge Programme, and it was initiated in April 2017.

The Vision and MissionTil toppen

Our vision is to establish a world class center for oral drug delivery of biopharmaceuticals. We will study how to overcome biological barriers by formulation design through interdisciplinary research collaborations.

The mission is to provide a better understanding and novel methods for oral delivery of biopharmaceuticals through tailoring of drug delivery systems and advanced assessment tools.

Specific selection criteria for use of excipients and formulation technologies relating to the properties of the biopharmaceuticals will be applied. We will decipher the influence of the physical and metabolic barrier properties at the specific site of absorption.Til toppen